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Vitamin D3 is derived from sheepskin oil collected during shearing. It is rapidly converted in the body to the active hormone 1,25 dihydrocholecalciferol. Adequate 1,25 (OH) D is responsible for proper function of bone growth and metabolism, and muscle function. Studies show large sections of the population in the northern latitudes are vitamin D deficient.

AOR guarantees that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, corn, nuts, dairy, soy, eggs, fish or shellfish.

Suggested Use
Take one capsules per day with food, or as directed by a qualified health care practitioner.

Main Applications
Calcium absorption
Bone health
Auto Immune Disorders
Immune support
Normal cellular growth and differentiation

Pregnancy / Nursing
No studies, best to avoid.

Source
Lanolin

Cautions
None known.


AOR Vitamin D3

Research

Background Information

The Importance of Sunshine

The term vitamin as applied to vitamin D is inaccurate because it is
synthesized by the skin following exposure to sunlight. Synthesis is
dependent upon numerous factors including the type of ultraviolet and
intensity, duration of exposure, skin pigmentation, age, altitude,
latitude, hour of day and time of season.

Vitamin D Deficiency - A Common Problem in all Age Groups
Vitamin D deficiency is widespread across all population groups. Most
physicians recognize that the elderly population is at risk, however it
is less appreciated that children, young adults and middle age groups
are also at risk. Supplementing with vitamin D can have a positive
impact on the ability of the body to fight against illness such as
cancer and seasonal affective disorder; it may also benefit chronic
pain, autoimmune diseases and many other health conditions.

Research

The Need for Sunshine
UVB exposure to the skin epidermis produces vitamin D, which
then undergoes hydroxylation (addition of OH or hydroxyl group) first in
the liver and then in the kidneys to produce the active hormone 1,
25-dihydroxy vitamin D. Studies have shown that children in areas
ranging from Madrid, Spain to Maine, New York were approximately 50%
deficit in vitamin D in the winter months. Apart from those who live in
equilateral regions, most people do not synthesize sufficient amounts of
vitamin D. For instance, in Edmonton, which is 52N, vitamin D synthesis
is impaired from October through to March. This problem is further
accentuated by misinformation and inappropriate statements of avoiding
sun and overuse of sunscreen by public health services. No doubt sun
over exposure is associated strongly with skin cancer but too little
vitamin D synthesis also has its own unique health problems.

Multiple Purposes
Vitamin D deficiencies have been associated with increased
hypertension, increased auto-immune diseases and various forms of cancer
including breast, prostate and skin. Low Vitamin D is associated with
chronic pain, premenstrual syndrome (PMS), poor immune system, diabetes,
seasonally affective disorders and even an increased risk of mortality
by all causes. Studies also suggest that vitamin D has important
immunological and antibacterial effects, and may be important for
preventing infections and even the common cold.

Pregnancy & Infants
Vitamin D supplementation is also important during pregnancy
and at very young ages, as inadequate vitamin D levels early in life
have been associated with an increased risk of autoimmune disorders like
multiple sclerosis, breathing disorders and type 1 diabetes later in
life. For example, infants receiving 2000 IU of vitamin D in the first
year of life were 80% less likely to develop type 1 diabetes. There may
also be a link between vitamin D and autism, as autism is much more
prevalent in areas of low sunlight. Vitamin D has also been shown to
play a role in immunity, and may help to prevent placental infections
during pregnancy.

Bone Health for Children
The most well-known role of vitamin D is its involvement in
maintaining healthy bones. In children, vitamin D is essential for the
proper growth and development of bones, and deficiency can result in
rickets. Vitamin D is critical for bone health because it is required
for the efficient utilization of dietary calcium. If vitamin D levels
are too low, the body will begin to break down the bones to access
calcium stores. Research has shown that vitamin D supplementation early
in life leads to higher bone mineral density (BMD) at 7-9 years of age,
and that adolescents with low vitamin D levels have lower BMD.

Bone Health for Adults
1, 25(OH) D is responsible for not only the bone development
and growth in children and maintenance of bone in adults, but also for
the prevention of osteoporosis and fractures in the elderly. In adults,
supplementation with 800 IU of vitamin D has been linked to a 26%
reduction of hip fractures and a 23% reduction in non-vertebral
fractures. In adults and older individuals, vitamin D deficiency results
in osteomalacia (a softening of the bones), a condition characterized
by inadequate bone mineralization. Vitamin D is essential for the
efficient utilization of dietary calcium. Blood calcium levels are
tightly regulated. In a vitamin D deficient state, the amount of calcium
absorbed is inadequate to satisfy the body's requirement, this causes
the body to release the hormone PTH (parathyroid hormone) which
activates the cells (osteoclasts) to breakdown the bone to get the much
needed calcium. This results in osteopenia and osteoporosis.

Additionally, PTH causes the kidneys to excrete phosphate and the
overall net result is a decrease in calcium phosphate, the major mineral
required for mineralizing bone. The bone building cells-osteoblasts
continue to deposit collagen matrix, resulting in rubbery matrix which
expands upon hydration and causes pressure and a low grade unrelenting
pain often misdiagnosed as fibromyalgia.

D Deficiency & Pain
One study found low levels of vitamin D in one in four patients
who suffer from chronic pain. Patients with inadequate levels of
vitamin D required nearly twice the dose of morphine that was used by
patients with normal levels, and the vitamin D deficiency group used
morphine for an average of 71.1 months compared to 43.8 months for
non-deficient patients. These results led the researchers to hypothesize
that while vitamin D deficiency is not the principle cause of chronic
pain, it may be a contributing factor, and one that can be alleviated by
supplementation.

Muscular Function
Vitamin D is also important in the function of muscles.
Research has shown that young girls (12-14 years old) with higher
vitamin D levels demonstrate greater muscle power than those with lower
levels. Muscle weakness, pain and changes in gait have been described in
vitamin D insufficiency. This may be the reason that the elderly have
more falls and consequently increased fracture rates.

Market Trends

In recent years, the importance of vitamin D has
been widely publicized, and it has become like the new vitamin C, a
cure-all. Many people have been found to be deficient in it, and it is
critical for the maintenance of health and wellness. More and more
research is uncovering the link between vitamin D deficiency and many
health conditions and diseases. The most common forms of vitamin D are
vitamin D2 (found in plants) and Vitamin D3 (derived from animal
sources). Vitamin D3 is better absorbed than D2.

AOR Advantage

AOR's Vitamin D3

provides and effective source of
natural vitamin D3 from lanolin, a naturally occurring oil found in the
wool of sheep. No harm comes to the animals during shearing. Vitamin D3
is much better absorbed than Vitamin D2, which is a plant source. AOR
offers vitamin D3 in capsule and in several liquid formats including a
children's formula for your convenience.

References

Bailey R, Cooper JD, Zeitels L, Smyth DJ,
Yang JH, Walker NM, Hyppönen E, Dunger DB, Ramos-Lopez E, Badenhoop K,
Nejentsev S, Todd JA. Association of the vitamin D metabolism gene
CYP27B1 with type 1 diabetes. Diabetes. 2007 Jul 2.

Cauley JA, LaCroix AZ, Wu L, Horwitz M, Danielson ME, Bauer DC,
Lee JS, Jackson RD, Robbins JA, Wu C, Stanczyk FZ, LeBoff MS,
Wactawski-Wende J, Sarto G, Ockene J, Cummings SR. Serum
25-Hydroxyvitamin D Concentrations and Risk for Hip Fractures. Ann
Intern Med. 2008;149(4):242-250.

Hooten WM. Vitamin D inadequacy may exacerbate chronic pain. American Society of Anesthesiologists. 2007.

Ginde AA, Mansbach JM, Camargo CA. Association between serum
25-hydroxyvitamin D level and upper respiratory tract infection in the
third national health and nutrition examination survey. Arch Intern Med.
2009; 169(4): 384-390.

Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP.
Vitamin D and calcium supplementation reduces cancer risk: results of a
randomized trial. Am J Clin Nutr. 2007 Jun;85(6):1586-91.

Liu N, Kaplan AT, Low J, Nguyen L, Liu GY, Equils O and Hewison
M. Vitamin D induces innate antibacterial responses in human
trophoblasts via an intracrine pathway. Biology of Reproduction.
Published online November 12, 2008.

Melamed ML, Michos ED, Post W, Astor B. 25-Hydroxyvitamin D
Levels and the Risk of Mortality in the General Population. Arch Intern
Med. 2008;168(15):1629-1637.

Svoren BM, Volkenning LK, Wood JR, Laffel LMB. Significant
Vitamin D Deficiency in Youth with Type 1 Diabetes Mellitus. Journal of
Pediatrics. 2009; 154(1): 132-134.

Thomas J. Wang, Michael J. Pencina, Sarah L. Booth, Paul F.
Jacques, Erik Ingelsson, Katherine Lanier, Emelia J. Benjamin, Ralph B.
DAgostino, Myles Wolf and Ramachandran S. Vasan. Vitamin D Deficiency
and Risk of Cardiovascular Disease. Circulation published online Jan 7,
2008.

Ward KA, Das G, Berry JL, Roberts SA, Rawer R, Adams JE, Mughal
Z. "Vitamin D Status and Muscle Function in Post-Menarchal Adolescent
Girls." Journal of Clinical Endocrinology & Metabolism. 2009
Feb;94(2):559-63.

Ward LM, Gaboury I, Ladhani M, Zlotkin S. Vitamin D-deficiency rickets among children in Canada. CMAJ. 2007 Jun 28.



Brand:
A.O.R Advanced Orthomolecular Research

Category: AOR brand

UPC: 2491704188
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