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60 Vegi-Caps AOR04186
Serving Size: 2 Capsules
GABA (Gamma Aminobutyric Acid) 100mg
L-5-Hydroxytryptophan (Griffonia Seed) 100mg
Valerian Root (0.8% Valerenic acid) 150mg
Passionflower (3.5% Vitexin) 32mg
CYRACOSTM (lemon balm extract)† 300mg
Non-medicinal ingredients: Capsule; hypromellose, sorbitol, silicon dioxide, water
Suntheanine is a registered trademark of Taiyo International, Inc.
†CYRACOS is a registered trademark of Naturex, Inc.
AOR guarantees that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, corn, nuts, soy, eggs, dairy, fish or shellfish.
Take 1-2 capsules before bedtime or as directed by a qualified health care practitioner.
Promotes Sleep and Relaxation
Pregnancy / Nursing
Do not use if pregnant or nursing.
Do not use if taking immunosuppressive drugs. Do not drive or use machinery for 5 hours after taking OrthoSleep
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AOR Ortho Sleep
Sleep - Essential but Neglected
Many people have trouble sleeping or have disrupted sleep
patterns. People suffering from insomnia spend less time in deeper
levels of sleep, wake up more often, and experience a reduction in REM
sleep. In addition to stress, insomnia can be caused by a variety of
other factors, including anxiety, poor diet, or a disruption of the
body's internal clock - such as jet lag, all-night study sessions, or
changing work hours.
OrthoSleep contains a carefully formulated blend of nutrients and
compounds that have been shown to be effective in combating insomnia and
promoting healthy, restful sleep. These include neurotransmitters like
GABA and melatonin, as well as 5-HTP, a serotonin precursor. The formula
further includes the amino acid L-theanine as well as valerian root,
passionflower extract, and lemon balm, all of which possess relaxing
properties, and work to increase the activity of GABA in the brain.
L-Theanine is a non-essential amino acid found in green tea,
and is responsible for the attribute known as 'relaxed alertness' that
is associated with this famous eastern beverage. It can act directly on
the brain, influencing brain wave patterns in a similar fashion to GABA,
and also indirectly by stimulating GABA production. Supplemental
L-theanine is also known to reduce anxiety by increasing ?-brain waves,
which the brain produces in significant quantities only in states of
effortless and relaxed alertness. This is precisely the kind of state
that precedes stage I sleep.
Neurotransmitters are the key to sleep regulation. These chemicals are
like tiny messengers in the brain, transmitting signals from one neuron
to another and modulating a huge number of functions in the human body,
including sleep. Gamma-aminobutyric acid (or GABA) is the most important
inhibitory neurotransmitter in the brain. GABA acts like a "brake"
during times of stress or anxiety, regulating brain excitability and
inducing relaxation. GABA receptors are highly concentrated in the
hypothalamus; the region of the brain associated with sleep. GABA is
effective against insomnia, and has been shown to affect the brain
directly, increasing ?-brain waves (those associated with relaxation)
and reducing ?-brain waves (those associated with anxiety and stress).
Melatonin and serotonin are also key neurotransmitters. Melatonin is
produced by the pineal gland in the brain, and it controls the body's
internal clock. Melatonin has been shown to increase sleep time and
reduce the time it takes to fall asleep. It can also help to reset the
body's sleep-wake cycle, a benefit to those suffering from jet lag or a
Serotonin is essential for sleep modulation in its own right, and can
also be converted by the body into melatonin. 5-HTP is
(L)5-hyrdoxytryptophan, a metabolite of the amino acid tryptophan and a
precursor to serotonin and melatonin. 5-HTP boosts serotonin levels, and
can also increase REM and deep sleep phases, making sleep more restful.
Valerian root (from the genus Valeriana with sub-species located
worldwide) has been used for millennia in the traditional folk remedies
of a wide range of cultures (from ancient China to ancient Greece) to
promote calmness, relaxation and sleep. Valerian root contains essential
oils which provide most of its sedative effect, while fractions known
as valepotriates add a regulatory inhibiting effect on the central
nervous system. There are about 150 other constituents of Valerian, a
great many of which act synergistically to account for Valerian's
overall efficacy, which includes the stimulation of GABA.
Passionflower, or Passiflora incarnate L., is officially listed
as a sleep aid in the monographs of the European Medicines Agency (an
EU organization) as well as the National Heath Products Directorate (a
division within Health Canada). Curiously, this is in spite of the fact
that clinical studies with this product pertain mainly to anxiety and
only in combination with other substances. Its ability to achieve such
prominent recognition in spite of this is testament to the strength of
passionflower's reputation in traditional medicine and preventative
Melissa officinalis L, commonly known as lemon balm, is
classified as a sleep aid in the monographs of the British, European
(EU) and German Commission E Pharmacopeias as well as in the compendium
of the Natural Health Products Directorate of Health Canada. With roots
originating in the folk medicine traditions of southern Europe, lemon
balm - like passionflower - has demonstrated its greatest efficacy when
used with other herbal extracts.
Sleeping is Like Your Job
Rest is just as important as work. No one can achieve their full
potential at work or school if the resources upon which that potential
relies cannot replenish themselves. Even the benefits of a healthy diet
and exercise are severely compromised (and the latter can even become
detrimental) without the re-charging of the biological batteries that
only quality sleep can provide. However, insomnia - as a symptom of
modern stress - plagues about one in seven people at any given time, and
most people will endure at least a temporary bout of some type of sleep
disorder at least once in their lifetime. In addition to impaired
cognitive and physical performance, insomnia can also lead to
depression, increased accident risk and even heart disease.
Stages of Sleep
Sleep is regulated by the body's internal clock, which keeps track of
light levels, the time of day and other important cues for sleep and
awakening. There are two primary types of sleep; REM (Rapid Eye
Movement) sleep, which is dreaming sleep, and Non-REM sleep, which
consists of four stages of progressively deeper sleep, all of which
precede REM sleep. While all sleep stages are important, stages III and
IV of deep sleep and REM sleep are especially vital.
Neurotransmitter #1: GABA
In a small, unpublished study, GABA supplementation reduced sleep
latency (transition time from wakefulness to stage I of Non-REM sleep)
by 20%, and increased the time spent in late-stage deep sleep by another
Neurotransmitter #2: Melatonin
Supplemental melatonin's effects on sleep are extensive and
well documented. One study with delayed sleep-phase insomniacs reduced
sleep latency times by an average of 115 minutes. Supplemental melatonin
is particularly well-researched with respect to dealing with
disruptions in the body's internal clock, such as jet lag and shift
work, with no fewer than 10 clinical studies demonstrating its ability
to resynchronize the body's altered circadian rhythms governing sleep.
Neurotransmitter #3: Serotonin
Supplemental 5-HTP has been successfully studied for the
treatment of a number of conditions, including mood balance, chronic
fatigue, and migraines. Studies examining its positive effects on sleep
go back to the early 1970?s, and a recent study revealed that 5-HTP
supplementation was able to reduce the number of sleep-terror episodes
in children by nearly 84%.
There are several placebo-controlled human studies attesting to
Valerian's effectiveness against insomnia, particularly via the
reduction of sleep latency and the improvement in sleep quality. These
studies were also fairly large and spanned a wide range of age groups
from both genders, with one study conducted among 128 test subjects
where the greatest benefit was for self-described "poor sleepers".
In one non-randomized clinical trial, 20 patients with
psychosomatic disorders were administered with either a
passionflower/valerian root combination or the neuroleptic drug
Propaphenin®. While the latter required six weeks to reduce cranial
hyperactivity (using EEG brain mapping), the passionflower/valerian root
extract combination did so in two. This led the scientists to conclude
that "the combination product containing P. incarnata was more efficient
than Propaphenin®" and "has a remarkable position as an 'herbal
sedative' in the OTC market." These observations can easily be carried
over to have a clear effect on reducing sleep latency and to a lesser
extent on improving sleep quality.
At least half a dozen human studies, mainly in combination with
valerian root, have examined lemon balm's effects on various sleep
disorders - with consistently positive results. In one multicentre,
double-blind, placebo-controlled study among 98 healthy volunteers with
minor sleep disorders, 33.3% of the study group reported an improvement
in sleep quality vs. 9.4% of the placebo group. In another multicentre
trial (this one being open), 225 patients with difficulties falling
asleep, staying asleep, and experiencing states of nervous agitation
participated. After taking the lemon balm-containing combination for 2
weeks, 89% saw improvements in falling asleep, 80% saw improvements in
staying asleep, and 82% experienced ameliorations in nervous agitation.
Sleep problems are not uncommon for many people;
they can have a dramatic negative impact on one's quality of life. Some
people resort to medications to help them sleep such as Zopiclone,
Lunesta, Ambian or Ativan. Alternatively, there are also natural
relaxants and sleep aids that can be used to aid in the management of
chronic sleep problems.
Ortho·Sleep™was specifically formulated to be
the most comprehensively powerful natural sleep aid available. Its
potency is designed to effectively address short-term sleep disorders
due to anxiety, stress, and/or a disruption of the body's internal clock
due to such factors as shift work and/or jetlag. Due to its
unprecedented potency, Ortho·Sleep™ must only be used as directed.
Brendler T, et al. Lemon Balm (Melissa
officinalis L.): An Evidence-Based Systematic Review by the Natural
Standard Research Collaboration. Journal of Herbal Pharmacotherapy;
2005, Vol. 5; Issue 4, p71-114.
Bruni O, Ferri R, Miano S, Verrillo E. L -5-Hydroxytryptophan
treatment of sleep terrors in children. Eur J Pediatr. 2004
Dhawan K, Dhawan S, Sharma A. Passiflora: a review update. J Ethnopharmacol. 2004 Sep;94(1):1-23.
Gamma-aminobutyric acid (GABA), Monograph. Altern Med Rev. 2007 Sep;12(3):274-9.
Ito K, Nagato Y, Aoi N, et al. Effects of Ltheanine on the
release of alpha-brain waves in human volunteers. Nippon Nogeikagaku
Melatonin. Monograph. Altern Med Rev. 2005 Dec;10(4):326-36.
Monograph. Valeriana officinalis. Altern Med Rev. 2004 Dec;9(4):438-41.
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