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Higher Resting Heart Rate, Higher Risk of Death

Posted June 17, 2013

By a News Reporter-Staff News Editor at Cardiovascular Week — A resting heart rate – the number of heart beats per minute – is determined by an individual’s level of physical fitness, circulating hormones, and the autonomic nervous system. A rate at rest of between 60 and 100 beats per minute is considered normal.

People who are very physically active tend to have a low heart rate at rest, but the authors wanted to find out if heart rate had any bearing on an individual’s risk of death, irrespective of their level of cardiorespiratory fitness.

They therefore tracked the health of just under 3000 men for 16 years, all of whom were part of the Copenhagen Male Study. This was set up in 1970-71 to monitor the cardiovascular health of middle aged men at 14 large companies in Copenhagen.

In 1971 all participants were interviewed by a doctor about their health and lifestyle, including smoking and exercise, and given a check-up. Their cardiorespiratory fitness was assessed using a cycling test, set at three different levels of exertion.

In 1985-6, just under 3000 of these original participants were given a further check-up, to include measurements of height, weight, blood pressure, blood fats and blood glucose. Their resting heart rate was also recorded (ECG and VO2Max).

Sixteen years later in 2001, the researchers checked national Danish registers to find out which of these men had survived. Almost four out of 10 (39%; 1082) of the men had died by 2001.

Unsurprisingly, a high resting heart rate was associated with lower levels of physical fitness, higher blood pressure and weight, and higher levels of circulating blood fats. Similarly, men who were physically active tended to have lower resting heart rates.

But the results showed that the higher the resting heart rate, the higher was the risk of death, irrespective of fitness level.

After adjusting for factors likely to influence the results, a resting heart rate of between 51 and 80 beats per minute was associated with a 40 to 50% increased risk of death, while one between 81 and 90 beats per minute doubled the risk, compared with those with the lowest rate. A resting heart rate above 90 beats per minute tripled the risk.

On the basis of their findings, the authors calculated that every 10 to 22 additional beats per minute in resting heart rate increased the risk of death by 16%, overall.

When smoking was factored in, this showed that every 12 to 27 additional heartbeats per minute increased a smoker’s risk by 20%, with a 14% increase in risk for every additional 4 to 24 beats per minute for non-smokers.

The authors say that a great deal of attention has focused on resting heart rate as an indicator of longevity, but that it has not been clear whether a high rate is simply an indicator of low levels of physical fitness.

But they conclude: “We found that irrespective of level of physical fitness, subjects with high resting heart rates fare worse than subjects with lower heart rates. This suggests that a high resting heart rate is not a mere marker of poor physical fitness, but is an independent risk factor.”

Keywords for this news article include: Heart Rate, Hemodynamics, BMJ-British Medical Journal (see also BMJ-British Medical Journal).

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC

To see more of the NewsRx.com, or to subscribe, go to http://www.newsrx.com .

By a News Reporter-Staff News Editor at Cardiovascular Week -- A resting heart rate - the number of heart beats per minute - is determined by an individual's level of physical fitness, circulating hormones, and the autonomic nervous system. A rate at rest of between 60 and 100 beats per minute is considered normal.

People who are very physically active tend to have a low heart rate at rest, but the authors wanted to find out if heart rate had any bearing on an individual's risk of death, irrespective of their level of cardiorespiratory fitness.

They therefore tracked the health of just under 3000 men for 16 years, all of whom were part of the Copenhagen Male Study. This was set up in 1970-71 to monitor the cardiovascular health of middle aged men at 14 large companies in Copenhagen.

In 1971 all participants were interviewed by a doctor about their health and lifestyle, including smoking and exercise, and given a check-up. Their cardiorespiratory fitness was assessed using a cycling test, set at three different levels of exertion.

In 1985-6, just under 3000 of these original participants were given a further check-up, to include measurements of height, weight, blood pressure, blood fats and blood glucose. Their resting heart rate was also recorded (ECG and VO2Max).

Sixteen years later in 2001, the researchers checked national Danish registers to find out which of these men had survived. Almost four out of 10 (39%; 1082) of the men had died by 2001.

Unsurprisingly, a high resting heart rate was associated with lower levels of physical fitness, higher blood pressure and weight, and higher levels of circulating blood fats. Similarly, men who were physically active tended to have lower resting heart rates.

But the results showed that the higher the resting heart rate, the higher was the risk of death, irrespective of fitness level.

After adjusting for factors likely to influence the results, a resting heart rate of between 51 and 80 beats per minute was associated with a 40 to 50% increased risk of death, while one between 81 and 90 beats per minute doubled the risk, compared with those with the lowest rate. A resting heart rate above 90 beats per minute tripled the risk.

On the basis of their findings, the authors calculated that every 10 to 22 additional beats per minute in resting heart rate increased the risk of death by 16%, overall.

When smoking was factored in, this showed that every 12 to 27 additional heartbeats per minute increased a smoker's risk by 20%, with a 14% increase in risk for every additional 4 to 24 beats per minute for non-smokers.

The authors say that a great deal of attention has focused on resting heart rate as an indicator of longevity, but that it has not been clear whether a high rate is simply an indicator of low levels of physical fitness.

But they conclude: "We found that irrespective of level of physical fitness, subjects with high resting heart rates fare worse than subjects with lower heart rates. This suggests that a high resting heart rate is not a mere marker of poor physical fitness, but is an independent risk factor."

Keywords for this news article include: Heart Rate, Hemodynamics, BMJ-British Medical Journal (see also BMJ-British Medical Journal).

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2013, NewsRx LLC

To see more of the NewsRx.com, or to subscribe, go to http://www.newsrx.com .

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Healthy Lifestyle Lowers Breast Cancer Risk

Posted March 13, 2013

SAN ANTONIO – Women concerned about breast cancer should worry less about cellphones and hair dyes and worry more about weighing or drinking too much, exercising too little, using menopause hormones and getting too much radiation from medical tests. So says a new report on environmental risks by a respected panel of science advisers.

By environment they mean everything not governed by genes – what’s in the air and water but also diets, vitamin use and even things like working night shifts.

And while they lament that most chemicals in consumer goods get little safety testing, they find too few studies in people to say whether there is a breast cancer risk from certain pesticides, cosmetics or bisphenol A, known as BPA and used in many plastics and canned food liners, although it has been eliminated from baby bottles and many reusable beverage containers in recent years.

“We don’t have enough data to say `toss your water bottles,’” said Irva Hertz-Picciotto, chief of environmental and occupational health at the University of California, Davis.

She headed the Institute of Medicine panel – independent experts under the National Academy of Sciences who advise the government and others. This report was paid for by Susan G. Komen for the Cure, a breast cancer foundation. It was presented Wednesday at a cancer conference in Texas.

We’ve done a better job of treating breast cancer than preventing it, said Dr. Michael Thun, senior epidemiologist for the American Cancer Society, who helped review the report. Breast cancer death rates in the U.S. fell 31 percent from 1990 to 2007, but incidence rates declined only about 5 percent.

Weight and obesity matter because fat cells make estrogen, and that hormone fuels the growth of most breast cancers, he said.

Other factors are more complex. Moderate alcohol consumption may lower the risk of heart disease but seems to raise the risk of breast cancer a little.

The report sorts the evidence for higher breast cancer risk factors like this:

-Yes: Hormone therapy combining estrogen and progestin, excess weight after menopause, alcohol consumption and radiation from too many medical tests, especially during childhood. The panel doesn’t say how much radiation is too much, but says two or three abdominal CT scans give as much as atomic bomb survivors received. Mammograms use minuscule amounts and should not be avoided. Oral contraceptives slightly raise breast cancer risk while taken, although cancer rates are very low in the age groups that use them.

-No: Hair dyes and the kind of radiation from cellphones, microwaves and electronic gadgets.

-Probable: Smoking.

-Possible: Secondhand smoke, nighttime shift work and exposure to benzene and a couple other chemicals through jobs or from breathing car fumes or pumping gas. It is “biologically plausible” that BPA and certain other plastics ingredients might affect estrogen, which fuels most breast cancers, but evidence is mostly in animals and lab tests – not enough to judge whether they harm people, the panel concluded.

“There’s a tremendous desire to blame someone or something” for breast cancer, said Dr. Eric Winer, a cancer specialist at Dana-Farber Cancer Institute in Boston and chief scientific adviser to the Komen foundation.

“There’s a real danger in prematurely concluding that a substance is the culprit and then closing your eyes and not paying attention to what might be a much more concerning factor,” or substituting something for BPA that might be worse, he said.

Thun of the cancer society agreed.

“One should first do everything possible to address the known risk factors,” he said. “If I’m making the choices, I wouldn’t put this (BPA) at the top of my list.”

However, Laura Anderko, a Georgetown University Medical Center public health scientist, said she was “deeply disappointed” by the report’s heavy emphasis on personal responsibility for cancer prevention.

“It is in stark contrast to the President’s Cancer Panel report last year that has a strong call to action on chemical policy reform,” she wrote in an email.

About 230,000 cases of breast cancer are expected to be diagnosed this year in the U.S. Less than 10 percent of cases are due to inherited genes.

Online:

Report: http://tinyurl.com/7fotq65

Cancer meeting: http://www.sabcs.org

SAN ANTONIO - Women concerned about breast cancer should worry less about cellphones and hair dyes and worry more about weighing or drinking too much, exercising too little, using menopause hormones and getting too much radiation from medical tests. So says a new report on environmental risks by a respected panel of science advisers.

By environment they mean everything not governed by genes - what's in the air and water but also diets, vitamin use and even things like working night shifts.

And while they lament that most chemicals in consumer goods get little safety testing, they find too few studies in people to say whether there is a breast cancer risk from certain pesticides, cosmetics or bisphenol A, known as BPA and used in many plastics and canned food liners, although it has been eliminated from baby bottles and many reusable beverage containers in recent years.

"We don't have enough data to say `toss your water bottles,'" said Irva Hertz-Picciotto, chief of environmental and occupational health at the University of California, Davis.

She headed the Institute of Medicine panel - independent experts under the National Academy of Sciences who advise the government and others. This report was paid for by Susan G. Komen for the Cure, a breast cancer foundation. It was presented Wednesday at a cancer conference in Texas.

We've done a better job of treating breast cancer than preventing it, said Dr. Michael Thun, senior epidemiologist for the American Cancer Society, who helped review the report. Breast cancer death rates in the U.S. fell 31 percent from 1990 to 2007, but incidence rates declined only about 5 percent.

Weight and obesity matter because fat cells make estrogen, and that hormone fuels the growth of most breast cancers, he said.

Other factors are more complex. Moderate alcohol consumption may lower the risk of heart disease but seems to raise the risk of breast cancer a little.

The report sorts the evidence for higher breast cancer risk factors like this:

-Yes: Hormone therapy combining estrogen and progestin, excess weight after menopause, alcohol consumption and radiation from too many medical tests, especially during childhood. The panel doesn't say how much radiation is too much, but says two or three abdominal CT scans give as much as atomic bomb survivors received. Mammograms use minuscule amounts and should not be avoided. Oral contraceptives slightly raise breast cancer risk while taken, although cancer rates are very low in the age groups that use them.

-No: Hair dyes and the kind of radiation from cellphones, microwaves and electronic gadgets.

-Probable: Smoking.

-Possible: Secondhand smoke, nighttime shift work and exposure to benzene and a couple other chemicals through jobs or from breathing car fumes or pumping gas. It is "biologically plausible" that BPA and certain other plastics ingredients might affect estrogen, which fuels most breast cancers, but evidence is mostly in animals and lab tests - not enough to judge whether they harm people, the panel concluded.

"There's a tremendous desire to blame someone or something" for breast cancer, said Dr. Eric Winer, a cancer specialist at Dana-Farber Cancer Institute in Boston and chief scientific adviser to the Komen foundation.

"There's a real danger in prematurely concluding that a substance is the culprit and then closing your eyes and not paying attention to what might be a much more concerning factor," or substituting something for BPA that might be worse, he said.

Thun of the cancer society agreed.

"One should first do everything possible to address the known risk factors," he said. "If I'm making the choices, I wouldn't put this (BPA) at the top of my list."

However, Laura Anderko, a Georgetown University Medical Center public health scientist, said she was "deeply disappointed" by the report's heavy emphasis on personal responsibility for cancer prevention.

"It is in stark contrast to the President's Cancer Panel report last year that has a strong call to action on chemical policy reform," she wrote in an email.

About 230,000 cases of breast cancer are expected to be diagnosed this year in the U.S. Less than 10 percent of cases are due to inherited genes.

Online:

Report: http://tinyurl.com/7fotq65

Cancer meeting: http://www.sabcs.org

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Preventing Low Birth Weight Babies

Posted March 1, 2013

Daviess County was among the better counties in the state with just 8.6 percent of babies born with low weight, and mothers who received adequate prenatal care were at 93 percent, according to the Community Health Needs Assessment.

Low birth weight is 5-pounds, 8-ounces or less.

However, mothers who smoked during pregnancy were at 26 percent, a number that has been growing, not decreasing.

According to health officials, babies born with a low birth weight are more likely than babies of normal weight to require specialized medical care, and often must stay in the intensive care unit.

Low birth weight is often associated with premature birth.

While there have been many medical advances enabling premature infants to survive, there is still risk of infant death or long-term disability, officials said.

The most important things an expectant mother can do to prevent prematurity and low birth weight are to take prenatal vitamins, stop smoking, stop drinking alcohol and using drugs, and most importantly, get prenatal care, officials said.

Gail Wigginton, the Green River District Health Department’s Maternal and Child Health coordinator, said folic acid has prevented birth defects “for some time now.”

Dr. Ruth Ann Shepherd, director of the Division of Maternal and Child Health in the Kentucky Department for Public Health, said folic acid helps prevent birth defects of the brain and spine.

“If a woman plans to become pregnant, she should start taking folic acid a month before, and then also during pregnancy,” Wigginton said.

Meanwhile, women should begin prenatal care by the end of their first trimester of pregnancy, and, according to the American College of Obstetrics and Gynecology, have at least 13 prenatal visits for a full-term pregnancy.

Early prenatal care allows women and their health care providers to identify and, when possible, treat or correct health problems and health-compromising behaviors that can be particularly damaging during the initial stages of fetal development.

Increasing the number of women who receive prenatal care, and who do so early in their pregnancies, can improve birth outcomes and lower health care costs by reducing the likelihood of complications during pregnancy and childbirth, officials said.

Smoking during pregnancy poses risks for both mother and fetus, according to officials. A baby born to a mother who has smoked during her pregnancy is more likely to have under-developed lungs and a lower birth weight and is more likely to be born prematurely.

It is estimated that smoking during pregnancy causes up to 10 percent of all infant deaths. Even after a baby is born, second-hand smoking can contribute to Sudden Infant Death Syndrome, asthma onset and stunted growth.

“Our infant mortality is a little below the state average, which is good,” Wigginton said. “So, overall, Daviess County is doing well, but we can do better.”

Wigginton said education is one reason local women are performing better.

“The health department is doing a super job of getting folic acid to our patients,” she said. “And we try to make sure the health department patients are receiving adequate care, especially in the first trimester.”

The health department also talks to patients about eating habits, such as eating five fruits and vegetables a day, and limiting fat intake.

Rich Suwanski, 691-7315, or rsuwanski@messenger-inquirer.com

©2013 the Messenger-Inquirer (Owensboro, Ky.)

Visit the Messenger-Inquirer (Owensboro, Ky.) at www.messenger-inquirer.com

Daviess County was among the better counties in the state with just 8.6 percent of babies born with low weight, and mothers who received adequate prenatal care were at 93 percent, according to the Community Health Needs Assessment.

Low birth weight is 5-pounds, 8-ounces or less.

However, mothers who smoked during pregnancy were at 26 percent, a number that has been growing, not decreasing.

According to health officials, babies born with a low birth weight are more likely than babies of normal weight to require specialized medical care, and often must stay in the intensive care unit.

Low birth weight is often associated with premature birth.

While there have been many medical advances enabling premature infants to survive, there is still risk of infant death or long-term disability, officials said.

The most important things an expectant mother can do to prevent prematurity and low birth weight are to take prenatal vitamins, stop smoking, stop drinking alcohol and using drugs, and most importantly, get prenatal care, officials said.

Gail Wigginton, the Green River District Health Department's Maternal and Child Health coordinator, said folic acid has prevented birth defects "for some time now."

Dr. Ruth Ann Shepherd, director of the Division of Maternal and Child Health in the Kentucky Department for Public Health, said folic acid helps prevent birth defects of the brain and spine.

"If a woman plans to become pregnant, she should start taking folic acid a month before, and then also during pregnancy," Wigginton said.

Meanwhile, women should begin prenatal care by the end of their first trimester of pregnancy, and, according to the American College of Obstetrics and Gynecology, have at least 13 prenatal visits for a full-term pregnancy.

Early prenatal care allows women and their health care providers to identify and, when possible, treat or correct health problems and health-compromising behaviors that can be particularly damaging during the initial stages of fetal development.

Increasing the number of women who receive prenatal care, and who do so early in their pregnancies, can improve birth outcomes and lower health care costs by reducing the likelihood of complications during pregnancy and childbirth, officials said.

Smoking during pregnancy poses risks for both mother and fetus, according to officials. A baby born to a mother who has smoked during her pregnancy is more likely to have under-developed lungs and a lower birth weight and is more likely to be born prematurely.

It is estimated that smoking during pregnancy causes up to 10 percent of all infant deaths. Even after a baby is born, second-hand smoking can contribute to Sudden Infant Death Syndrome, asthma onset and stunted growth.

"Our infant mortality is a little below the state average, which is good," Wigginton said. "So, overall, Daviess County is doing well, but we can do better."

Wigginton said education is one reason local women are performing better.

"The health department is doing a super job of getting folic acid to our patients," she said. "And we try to make sure the health department patients are receiving adequate care, especially in the first trimester."

The health department also talks to patients about eating habits, such as eating five fruits and vegetables a day, and limiting fat intake.

Rich Suwanski, 691-7315, or rsuwanski@messenger-inquirer.com

©2013 the Messenger-Inquirer (Owensboro, Ky.)

Visit the Messenger-Inquirer (Owensboro, Ky.) at www.messenger-inquirer.com

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Diet Myths

Posted Jan 10, 2013

DIET season is upon us and you may have started on a new weightloss “theory”. But if your no-fat detox fasting frenzy isn’t working, it could be because it’s a myth. We go in search of the truth…

1 Low-fat or no-fat diets are good for you.

Myth

A third of your calories should come from fat. The body needs fat for energy, tissue repair and to transport vitamins.

As a guideline, women need 70g of fat a day (30g as the minimum) and men need 95g (40g minimum). Cut down on saturated fats in cream, cheese or butter for unsaturated fats, found in olive oil and avocados.

2 Crash dieting makes you lose weight.

Myth

Crash dieting or fasting can hinder weight loss as both remove fat and also lean muscle and tissue, which causes a fall in your basal metabolic rate – the amount of calories your body needs when it is resting.

This means your body comes to need fewer calories to stay the same, making weight gain more likely once you stop dieting. It is why exercise is recommended in any weight-loss plan to maintain your metabolic rate.

3 Low-fat milk contains less calcium than full-fat milk.

Myth

Skimmed and semi-skimmed milk have more calcium, because the calcium is in the watery not creamy part. If you want to lose weight, skimmed milk is your best option but use semi-skimmed to maintain a healthy lifestyle if you are not dieting.

4 A slow metabolism stops you losing weight.

Myth

The number of calories used by the body at rest increases as people become fatter. So, the larger you are, the more calories you need to keep your body going and the higher your metabolism becomes.

5 Eating a fattening meal will mean you pile on the pounds.

Myth

Weight gain is a slow process. You need to eat an extra 3,500 calories to gain 1lb of fat. If the scales say you have gained a few pounds after a meal, it is down to fluid retention.

6 Low-fat foods always help you lose weight.

Myth

Low-fat or fat-free does not always mean low calorie. Check the calories of foods, especially cakes, crisps, ice creams and ready meals. Extra sugars and thickeners are often added to boost flavour. Foods labelled low-fat should have no more than 3g fat per 100g.

7 Food eaten late at night is more fattening for you.

Myth

A large meal eaten late at night does not make the body store more fat, according to a study at Dunn Nutrition Centre, Cambridge. Volunteers were fed a large lunch and small evening meal for one test period, then a small lunch and large evening meal the next. The large meal eaten late did not make the body store more fat. So it is not when you eat that is important, but the total amount you consume during a 24-hour period.

8 Avoid fatty foods because they will raise your cholesterol.

Myth

Cholesterol can be bad for us because it forms deposits that clog our arteries, which contribute to heart disease. But we all need blood cholesterol for building cells and making hormones.

>Saturated fats found in meat, cheese, cream, butter and processed pastries tend to raise low-density lipoprotein cholesterol, known as bad cholesterol. Choose unsaturated fats such as vegetable oils, nuts and seeds.

9 Vegetarians can’t build up muscle mass.

Myth

Vegetarians can be as muscular as meat eaters by getting their protein from cheese, nuts, pulses and grains. You need protein to build muscle but the body can only store a certain amount of protein, so too much can damage the kidneys.

10 You always gain weight when you stop smoking.

Myth

While nicotine does increase metabolism, its effect is small. It is far healthier to be an overweight non-smoker than not bother giving up. Chew on sugar-free gum or snack on vegetables or satsumas until your cravings go away.

http://www.netdoctor.co.uk/womenshealth/features/dietmyths.htm

DIET season is upon us and you may have started on a new weightloss "theory". But if your no-fat detox fasting frenzy isn't working, it could be because it's a myth. We go in search of the truth...

1 Low-fat or no-fat diets are good for you.

Myth

A third of your calories should come from fat. The body needs fat for energy, tissue repair and to transport vitamins.

As a guideline, women need 70g of fat a day (30g as the minimum) and men need 95g (40g minimum). Cut down on saturated fats in cream, cheese or butter for unsaturated fats, found in olive oil and avocados.

2 Crash dieting makes you lose weight.

Myth

Crash dieting or fasting can hinder weight loss as both remove fat and also lean muscle and tissue, which causes a fall in your basal metabolic rate - the amount of calories your body needs when it is resting.

This means your body comes to need fewer calories to stay the same, making weight gain more likely once you stop dieting. It is why exercise is recommended in any weight-loss plan to maintain your metabolic rate.

3 Low-fat milk contains less calcium than full-fat milk.

Myth

Skimmed and semi-skimmed milk have more calcium, because the calcium is in the watery not creamy part. If you want to lose weight, skimmed milk is your best option but use semi-skimmed to maintain a healthy lifestyle if you are not dieting.

4 A slow metabolism stops you losing weight.

Myth

The number of calories used by the body at rest increases as people become fatter. So, the larger you are, the more calories you need to keep your body going and the higher your metabolism becomes.

5 Eating a fattening meal will mean you pile on the pounds.

Myth

Weight gain is a slow process. You need to eat an extra 3,500 calories to gain 1lb of fat. If the scales say you have gained a few pounds after a meal, it is down to fluid retention.

6 Low-fat foods always help you lose weight.

Myth

Low-fat or fat-free does not always mean low calorie. Check the calories of foods, especially cakes, crisps, ice creams and ready meals. Extra sugars and thickeners are often added to boost flavour. Foods labelled low-fat should have no more than 3g fat per 100g.

7 Food eaten late at night is more fattening for you.

Myth

A large meal eaten late at night does not make the body store more fat, according to a study at Dunn Nutrition Centre, Cambridge. Volunteers were fed a large lunch and small evening meal for one test period, then a small lunch and large evening meal the next. The large meal eaten late did not make the body store more fat. So it is not when you eat that is important, but the total amount you consume during a 24-hour period.

8 Avoid fatty foods because they will raise your cholesterol.

Myth

Cholesterol can be bad for us because it forms deposits that clog our arteries, which contribute to heart disease. But we all need blood cholesterol for building cells and making hormones.

>Saturated fats found in meat, cheese, cream, butter and processed pastries tend to raise low-density lipoprotein cholesterol, known as bad cholesterol. Choose unsaturated fats such as vegetable oils, nuts and seeds.

9 Vegetarians can't build up muscle mass.

Myth

Vegetarians can be as muscular as meat eaters by getting their protein from cheese, nuts, pulses and grains. You need protein to build muscle but the body can only store a certain amount of protein, so too much can damage the kidneys.

10 You always gain weight when you stop smoking.

Myth

While nicotine does increase metabolism, its effect is small. It is far healthier to be an overweight non-smoker than not bother giving up. Chew on sugar-free gum or snack on vegetables or satsumas until your cravings go away.

http://www.netdoctor.co.uk/womenshealth/features/dietmyths.htm

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A Little Alcohol May Prevent Arthritis in Women

Posted July 19, 2012

WOMEN who drink moderate amounts of alcohol are less likely to get rheumatoid arthritis than those who do not drink, research suggests.

Drinking more than three glasses a week for at least ten years halves the risk of rheumatoid arthritis, researchers found.

The study of more than 34,000 Swedish women found the risk among those who drank more than three glasses of alcohol per week in 1987 and 1997 was 52 per cent lower than those who were never drank.

The researchers gathered information on alcohol consumption, diet, smoking history, physical activity and education level between 1987 and 1997. Rheumatoid arthritis affects one per cent of the world’s population.

WOMEN who drink moderate amounts of alcohol are less likely to get rheumatoid arthritis than those who do not drink, research suggests.

Drinking more than three glasses a week for at least ten years halves the risk of rheumatoid arthritis, researchers found.

The study of more than 34,000 Swedish women found the risk among those who drank more than three glasses of alcohol per week in 1987 and 1997 was 52 per cent lower than those who were never drank.

The researchers gathered information on alcohol consumption, diet, smoking history, physical activity and education level between 1987 and 1997. Rheumatoid arthritis affects one per cent of the world's population.

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Tobacco Control Programs Work

March 20, 2012

-U.S. tobacco-control programs prevented nearly 800,000 lung cancer deaths in the last quarter of the 20th century, but more than three times as many could have been spared had the entire population stopped smoking in 1965, according to a landmark study released Wednesday.

The study, conducted by researchers at Rice University, the University of Texas M.D. Anderson Cancer Center and other institutions, provides the first numbers showing the life-saving effect of tobacco tax hikes, bans on smoking in public places, limiting underage access and public education campaigns.

“This study is proof of how well these programs work,” said Olga Gorlova, a professor of epidemiology at M.D. Anderson and one of the study authors. “Screening is good secondary prevention, but we now know just how many deaths primary prevention can avert.”

Gorlova said she hopes the findings lead to more aggressive tobacco control efforts. She singled out the need to counter tobacco companies’ targeting of young people, the time when most smokers acquire the habit.

The study, published online Wednesday in the Journal of the National Cancer Institute, was based on sophisticated modeling that estimated the numbers of smoking-related lung cancer deaths from constructed tobacco-use histories of people born from 1890 through 1970. Six different models, the Rice-M.D. Anderson team’s among them, reached similar conclusions.

Despite more than 40 years of tobacco-control programs, lung cancer remains the leading cause of cancer deaths for men and women, killing more than 160,000 annually in the U.S. More than 80 percent of lung cancer cases are attributed to smoking.

Gorlova called the study’s estimate of smoking-related lung cancer deaths on the “low side,” and stressed it did not consider the influence of smoking on other cancers and diseases, such as emphysema and heart disease.

Twin projections

To arrive at their numbers, researchers projected two scenarios — if all smoking in the United States stopped in 1965 and if there were no change in smoking trends starting that year — and compared them to smoking and lung cancer death data. About 2.5 million deaths would have been prevented had everyone stopped smoking, they found.

The 800,000 prevented deaths included 552,0000 men and 243,000 women.

David Sylvia, a spokesman for Philip Morris USA, said company officials couldn’t comment on the study because they hadn’t reviewed it. He acknowledged in a statement that smoking is “addictive and causes serious disease” and said the company agreed with established anti-smoking approaches.

“A complementary strategy, focused on the development of and appropriate communications about potentially lower risk tobacco products, may be one of the most meaningful actions that the Food & jDrug Administration can take to reduce the health effects of smoking,” the statement said.

Lack of will blamed

Smoking rates have declined in America since the 1960s, when the Surgeon General’s Report on Smoking and Health prompted anti-smoking interventions. In 1964, 53 percent of men and 32 percent of women smoked.

By 2008, the numbers had dropped to 23 percent and 18 percent, respectively. But the reduction has slowed in recent years. A surgeon general’s report last week said steep declines in youth smoking and the use of smokeless tobacco had leveled off, a trend that the NCI’s Thomas Glynn attributed to a mid-1990s complacency about anti-smoking efforts. b

Glynn said anti-smoking interventions have picked up again in recent years, particularly tax hikes and restrictions on smoking in public places. In Houston, those restrictions now extend from restaurants and bars to public parks.

Still, in an accompanying editorial in the NCI journal, Glynn asked how, over the past 100 years, “we allowed tobacco to kill and cause disease with such abandon.”

“Despite knowing what works and having the science to back that up, we have often lacked the political and financial will to do what is necessary to take full advantage of our knowledge and put an end to the scourge of tobacco in our society,” wrote Glynn, the NCI’s director of cancer research and trends.

todd.ackerman@chron.com

©2012 the Houston Chronicle

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March 20, 2012

-U.S. tobacco-control programs prevented nearly 800,000 lung cancer deaths in the last quarter of the 20th century, but more than three times as many could have been spared had the entire population stopped smoking in 1965, according to a landmark study released Wednesday.

The study, conducted by researchers at Rice University, the University of Texas M.D. Anderson Cancer Center and other institutions, provides the first numbers showing the life-saving effect of tobacco tax hikes, bans on smoking in public places, limiting underage access and public education campaigns.

"This study is proof of how well these programs work," said Olga Gorlova, a professor of epidemiology at M.D. Anderson and one of the study authors. "Screening is good secondary prevention, but we now know just how many deaths primary prevention can avert."

Gorlova said she hopes the findings lead to more aggressive tobacco control efforts. She singled out the need to counter tobacco companies' targeting of young people, the time when most smokers acquire the habit.

The study, published online Wednesday in the Journal of the National Cancer Institute, was based on sophisticated modeling that estimated the numbers of smoking-related lung cancer deaths from constructed tobacco-use histories of people born from 1890 through 1970. Six different models, the Rice-M.D. Anderson team's among them, reached similar conclusions.

Despite more than 40 years of tobacco-control programs, lung cancer remains the leading cause of cancer deaths for men and women, killing more than 160,000 annually in the U.S. More than 80 percent of lung cancer cases are attributed to smoking.

Gorlova called the study's estimate of smoking-related lung cancer deaths on the "low side," and stressed it did not consider the influence of smoking on other cancers and diseases, such as emphysema and heart disease.

Twin projections

To arrive at their numbers, researchers projected two scenarios -- if all smoking in the United States stopped in 1965 and if there were no change in smoking trends starting that year -- and compared them to smoking and lung cancer death data. About 2.5 million deaths would have been prevented had everyone stopped smoking, they found.

The 800,000 prevented deaths included 552,0000 men and 243,000 women.

David Sylvia, a spokesman for Philip Morris USA, said company officials couldn't comment on the study because they hadn't reviewed it. He acknowledged in a statement that smoking is "addictive and causes serious disease" and said the company agreed with established anti-smoking approaches.



"A complementary strategy, focused on the development of and appropriate communications about potentially lower risk tobacco products, may be one of the most meaningful actions that the Food & jDrug Administration can take to reduce the health effects of smoking," the statement said.

Lack of will blamed

Smoking rates have declined in America since the 1960s, when the Surgeon General's Report on Smoking and Health prompted anti-smoking interventions. In 1964, 53 percent of men and 32 percent of women smoked.

By 2008, the numbers had dropped to 23 percent and 18 percent, respectively. But the reduction has slowed in recent years. A surgeon general's report last week said steep declines in youth smoking and the use of smokeless tobacco had leveled off, a trend that the NCI's Thomas Glynn attributed to a mid-1990s complacency about anti-smoking efforts. b

Glynn said anti-smoking interventions have picked up again in recent years, particularly tax hikes and restrictions on smoking in public places. In Houston, those restrictions now extend from restaurants and bars to public parks.

Still, in an accompanying editorial in the NCI journal, Glynn asked how, over the past 100 years, "we allowed tobacco to kill and cause disease with such abandon."

"Despite knowing what works and having the science to back that up, we have often lacked the political and financial will to do what is necessary to take full advantage of our knowledge and put an end to the scourge of tobacco in our society," wrote Glynn, the NCI's director of cancer research and trends.

todd.ackerman@chron.com

©2012 the Houston Chronicle

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Women More Likely to Die from Heart Attacks

Posted March 16, 2012

A new study out of Florida finds women are less likely to get immediate treatment for heart attacks and are more likely to die in the hospital than men.

The Lakeland Regional Medical Center in Florida tracked 1.1 million patients. Women had a 15 percent chance of dying of a heart attack in the hospital compared to men’s 10 percent. One of the reasons for the higher numbers among women, 42 percent of women never experienced the classic heart attack symptom of chest pain or pressure.

“Women often present with suddenly feeling tired, fatigue, nausea, reduced exercise tolerance, rather vague,” said Dr. Ed Fry, cardiologist at St. Vincent Heart Center.

Dr. Fry said one of the reasons for the different symptoms is because women have smaller blood vessels than men. It’s something he and his colleagues are studying at St. Vincent’s Heart Center.

Cynthia Haverstick is a heart attack survivor. She said her symptoms weren’t very clear.

“I wouldn’t be able to breathe properly, I would tire easily, I had trouble lifting things. I just figured it was me and it would go away eventually.”

Haverstick said it all hit her what was going on. In May 2010, it was confirmed.

“Once I realized what was going on and I got to the hospital, they confirmed I had a heart attack.”

Dr. Fry said it’s important to talk to your primary care doctor and know your own risks. There are things you can do right now to help. Know your family history, exercise and watch your weight. Know your cholesterol, blood pressure, blood sugar and if you’re pre-diabetic or diabetic. Most importantly, he said you shouldn’t smoke and if you do, quit.

“We know smoking is one of the most serious risk factors and one of the most modifiable risk factors.”

Cynthia admits she is a typical mom and said she’s lucky there was no permanent damage to her heart.

“We think of everyone else and often time put ourselves on the bottom of the list.”

©2012 WXIN-TV (Indianapolis)

Visit WXIN-TV (Indianapolis) at www.fox59.com

A new study out of Florida finds women are less likely to get immediate treatment for heart attacks and are more likely to die in the hospital than men.

The Lakeland Regional Medical Center in Florida tracked 1.1 million patients. Women had a 15 percent chance of dying of a heart attack in the hospital compared to men's 10 percent. One of the reasons for the higher numbers among women, 42 percent of women never experienced the classic heart attack symptom of chest pain or pressure.

"Women often present with suddenly feeling tired, fatigue, nausea, reduced exercise tolerance, rather vague," said Dr. Ed Fry, cardiologist at St. Vincent Heart Center.

Dr. Fry said one of the reasons for the different symptoms is because women have smaller blood vessels than men. It's something he and his colleagues are studying at St. Vincent's Heart Center.

Cynthia Haverstick is a heart attack survivor. She said her symptoms weren't very clear.

"I wouldn't be able to breathe properly, I would tire easily, I had trouble lifting things. I just figured it was me and it would go away eventually."

Haverstick said it all hit her what was going on. In May 2010, it was confirmed.

"Once I realized what was going on and I got to the hospital, they confirmed I had a heart attack."

Dr. Fry said it's important to talk to your primary care doctor and know your own risks. There are things you can do right now to help. Know your family history, exercise and watch your weight. Know your cholesterol, blood pressure, blood sugar and if you're pre-diabetic or diabetic. Most importantly, he said you shouldn't smoke and if you do, quit.

"We know smoking is one of the most serious risk factors and one of the most modifiable risk factors."

Cynthia admits she is a typical mom and said she's lucky there was no permanent damage to her heart.

"We think of everyone else and often time put ourselves on the bottom of the list."

©2012 WXIN-TV (Indianapolis)

Visit WXIN-TV (Indianapolis) at www.fox59.com

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Heart Disease and Prostate Cancer Linked

Posted Feb 23, 2012

There appears to be a significant connection between two of the deadliest human illnesses — prostate cancer and heart disease — suggesting that they may have the same causes, according to a new study led by Duke Cancer Institute researchers.

If further research shows that both diseases have the same triggers, it could mean that it’s possible for men to reduce their risk of prostate cancer by making the straightforward, proven lifestyle changes for fighting heart disease, including improving diet, stopping smoking, reducing cholesterol levels and getting more exercise.

“That’s obviously what’s exciting to us about these results,” said Dr. Stephen Freedland, an associate professor of surgery and pathology in the Division of Urology at Duke and senior author of the paper.

The study appears online this month in the journal Cancer Epidemiology, Biomarkers & Prevention.

Previous studies into a possible link between the two diseases have offered conflicting results. This time, researchers found that the correlation is real, Freedland said.

“It’s not like every man in the study with heart disease had cancer,” he said. “But we can say that clearly if you do have heart disease, your risk of prostate cancer is higher.”

The researchers studied data from nearly 6,400 men who were enrolled in a large prostate drug trial. Of those, 547 reported a history of heart disease at the time they enrolled.

The men had prostate biopsies to test for cancer two years and four years into the study. Using results from those biopsies, the researchers found that having coronary artery disease increased the risk of prostate cancer by 35 percent averaged over the four-year study. That risk increased over time.

The study is not ideal, in part because it relied on data from an unrelated drug trial. In addition, the results simply show a link, pointing the way to further research into questions such as whether heart disease can somehow cause prostate cancer.

Still, the implications carry unusual weight because both diseases are major killers. Cancer of the prostate is the second-leading cause of cancer deaths among men, while heart disease is the single greatest killer of adults of both sexes, responsible for one in four deaths.

Price: 919-829-4526

___

©2012 The News & Observer (Raleigh, N.C.)

Visit The News & Observer (Raleigh, N.C.) at www.newsobserver.com

There appears to be a significant connection between two of the deadliest human illnesses -- prostate cancer and heart disease -- suggesting that they may have the same causes, according to a new study led by Duke Cancer Institute researchers.

If further research shows that both diseases have the same triggers, it could mean that it's possible for men to reduce their risk of prostate cancer by making the straightforward, proven lifestyle changes for fighting heart disease, including improving diet, stopping smoking, reducing cholesterol levels and getting more exercise.

"That's obviously what's exciting to us about these results," said Dr. Stephen Freedland, an associate professor of surgery and pathology in the Division of Urology at Duke and senior author of the paper.

The study appears online this month in the journal Cancer Epidemiology, Biomarkers & Prevention.

Previous studies into a possible link between the two diseases have offered conflicting results. This time, researchers found that the correlation is real, Freedland said.

"It's not like every man in the study with heart disease had cancer," he said. "But we can say that clearly if you do have heart disease, your risk of prostate cancer is higher."

The researchers studied data from nearly 6,400 men who were enrolled in a large prostate drug trial. Of those, 547 reported a history of heart disease at the time they enrolled.

The men had prostate biopsies to test for cancer two years and four years into the study. Using results from those biopsies, the researchers found that having coronary artery disease increased the risk of prostate cancer by 35 percent averaged over the four-year study. That risk increased over time.

The study is not ideal, in part because it relied on data from an unrelated drug trial. In addition, the results simply show a link, pointing the way to further research into questions such as whether heart disease can somehow cause prostate cancer.

Still, the implications carry unusual weight because both diseases are major killers. Cancer of the prostate is the second-leading cause of cancer deaths among men, while heart disease is the single greatest killer of adults of both sexes, responsible for one in four deaths.

Price: 919-829-4526

___

©2012 The News & Observer (Raleigh, N.C.)

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Functional Medicine Debate

Posted Feb 22, 2012

Whether science bears out Catherine Ruehle’s assertion that she is staying well through nutrition and lifestyle changes alone — without the use of prescription drugs — depends on which medical and nutrition experts are asked.

Those who adhere to the emerging philosophy of healthcare called “functional medicine” believe that chronic illnesses and autoimmune disorders such as rheumatoid arthritis are highly attributable to genetic makeup and environmental and lifestyle factors, and that those things should be taken into account by physicians. Too often, they say, doctors use an acute-care model (say, that of a broken bone or appendicitis) to treat chronic disease; they treat the symptoms rather than the causes. The Institute for Functional Medicine (www.functionalmedicine.org) states, “Most physicians are not adequately trained to assess the underlying causes of complex, chronic disease and to apply strategies such as nutrition, diet and exercise to both treat and prevent these illnesses in their patients.”

Fort Worth registered dietitian Kim Hogue, a member of the IMF, has not consulted with Ruehle but says she thinks her approach makes perfect sense.

“Food is medicine,” Hogue says, adding that gluten, in particular, is a substance that many people don’t know they’re sensitive to. One of the first courses of action she as a dietician would advise RA patients to take is to eliminate potential food triggers from their diet and slowly try to add them back in, as Ruehle did.

In fact, one study cited by WebMD in its Rheumatoid Arthritis Health Center indicates that 30 to 40 percent of RA patients may benefit by eliminating “suspect” foods from their diet, and that an elimination diet is a good way to identify them.

Dr. Virginia Reddy, clinical assistant professor of internal medicine in the division of rheumatology at UT Southwestern Medical Center, also has neither consulted with Ruehle nor seen her medical records. She says that, although some studies show that some foods can have an anti-inflammatory effect and that lifestyle factors such as stress and cigarette smoking can contribute to RA flare-ups, a lifestyle-only approach to managing the disease is risky.

“I think the vast majority of people would not have their disease controlled with such an approach,” she says. “There’s a spectrum of the disease from very mild to very severe, so potentially people with mild disease where there’s not any joint damage … could manage it well with lifestyle modifications, but for the vast majority it would be a risky approach because when left untreated, in [most patients], RA is going to be disabling.”

Although a diagnosis of RA used to be a “very scary sentence,” Reddy said, now there are very effective treatment options resulting from a tremendous amount of research going on every day.

Reddy acknowledges that RA drugs, including steroids, do have potentially harmful side effects. But most of her patients who have experienced the debilitating pain that comes with a full onset of RA “find it very much to be worth it,” she says.

Patients often do want to talk about lifestyle changes they can make to help control their arthritis.

“I definitely recommend to all my patients a generally healthy lifestyle, getting sleep, exercising, eating a healthy, balanced diet and not being overweight,” she says. But she adds, “In terms of an ‘RA diet,’ there have been some small studies looking at specific diets in RA patients, but they have not shown any conclusive results.”

These include studies investigating vegetarian, Mediterranean, elemental and elimination diets, Reddy said.

“However,” she said, “these studies were, in general, too small to draw any particular conclusions about these diets, as more patients on the diets in many of these studies both lost weight (which might have helped the arthritis), but also more patients dropped out of the treatment arms due to adverse events related to the diets.”

©2012 the Fort Worth Star-Telegram

Visit the Fort Worth Star-Telegram at www.star-telegram.com

Whether science bears out Catherine Ruehle's assertion that she is staying well through nutrition and lifestyle changes alone -- without the use of prescription drugs -- depends on which medical and nutrition experts are asked.

Those who adhere to the emerging philosophy of healthcare called "functional medicine" believe that chronic illnesses and autoimmune disorders such as rheumatoid arthritis are highly attributable to genetic makeup and environmental and lifestyle factors, and that those things should be taken into account by physicians. Too often, they say, doctors use an acute-care model (say, that of a broken bone or appendicitis) to treat chronic disease; they treat the symptoms rather than the causes. The Institute for Functional Medicine (www.functionalmedicine.org) states, "Most physicians are not adequately trained to assess the underlying causes of complex, chronic disease and to apply strategies such as nutrition, diet and exercise to both treat and prevent these illnesses in their patients."

Fort Worth registered dietitian Kim Hogue, a member of the IMF, has not consulted with Ruehle but says she thinks her approach makes perfect sense.

"Food is medicine," Hogue says, adding that gluten, in particular, is a substance that many people don't know they're sensitive to. One of the first courses of action she as a dietician would advise RA patients to take is to eliminate potential food triggers from their diet and slowly try to add them back in, as Ruehle did.

In fact, one study cited by WebMD in its Rheumatoid Arthritis Health Center indicates that 30 to 40 percent of RA patients may benefit by eliminating "suspect" foods from their diet, and that an elimination diet is a good way to identify them.

Dr. Virginia Reddy, clinical assistant professor of internal medicine in the division of rheumatology at UT Southwestern Medical Center, also has neither consulted with Ruehle nor seen her medical records. She says that, although some studies show that some foods can have an anti-inflammatory effect and that lifestyle factors such as stress and cigarette smoking can contribute to RA flare-ups, a lifestyle-only approach to managing the disease is risky.

"I think the vast majority of people would not have their disease controlled with such an approach," she says. "There's a spectrum of the disease from very mild to very severe, so potentially people with mild disease where there's not any joint damage ... could manage it well with lifestyle modifications, but for the vast majority it would be a risky approach because when left untreated, in [most patients], RA is going to be disabling."

Although a diagnosis of RA used to be a "very scary sentence," Reddy said, now there are very effective treatment options resulting from a tremendous amount of research going on every day.

Reddy acknowledges that RA drugs, including steroids, do have potentially harmful side effects. But most of her patients who have experienced the debilitating pain that comes with a full onset of RA "find it very much to be worth it," she says.

Patients often do want to talk about lifestyle changes they can make to help control their arthritis.

"I definitely recommend to all my patients a generally healthy lifestyle, getting sleep, exercising, eating a healthy, balanced diet and not being overweight," she says. But she adds, "In terms of an 'RA diet,' there have been some small studies looking at specific diets in RA patients, but they have not shown any conclusive results."

These include studies investigating vegetarian, Mediterranean, elemental and elimination diets, Reddy said.

"However," she said, "these studies were, in general, too small to draw any particular conclusions about these diets, as more patients on the diets in many of these studies both lost weight (which might have helped the arthritis), but also more patients dropped out of the treatment arms due to adverse events related to the diets."

©2012 the Fort Worth Star-Telegram

Visit the Fort Worth Star-Telegram at www.star-telegram.com

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Prostate Cancer and Heart Disease Linked

Posted Feb 10, 2012

There appears to be a significant connection between two of the deadliest human illnesses — prostate cancer and heart disease — suggesting that they may have the same causes, according to a new study led by Duke Cancer Institute researchers.

If further research shows that both diseases have the same triggers, it could mean that it’s possible for men to reduce their risk of prostate cancer by making the straightforward, proven lifestyle changes for fighting heart disease, including improving diet, stopping smoking, reducing cholesterol levels and getting more exercise.

“That’s obviously what’s exciting to us about these results,” said Dr. Stephen Freedland, an associate professor of surgery and pathology in the Division of Urology at Duke and senior author of the paper.

The study appears online this month in the journal Cancer Epidemiology, Biomarkers & Prevention.

Previous studies into a possible link between the two diseases have offered conflicting results. This time, researchers found that the correlation is real, Freedland said.

“It’s not like every man in the study with heart disease had cancer,” he said. “But we can say that clearly if you do have heart disease, your risk of prostate cancer is higher.”

The researchers studied data from nearly 6,400 men who were enrolled in a large prostate drug trial. Of those, 547 reported a history of heart disease at the time they enrolled.

The men had prostate biopsies to test for cancer two years and four years into the study. Using results from those biopsies, the researchers found that having coronary artery disease increased the risk of prostate cancer by 35 percent averaged over the four-year study. That risk increased over time.

The study is not ideal, in part because it relied on data from an unrelated drug trial. In addition, the results simply show a link, pointing the way to further research into questions such as whether heart disease can somehow cause prostate cancer.

Still, the implications carry unusual weight because both diseases are major killers. Cancer of the prostate is the second-leading cause of cancer deaths among men, while heart disease is the single greatest killer of adults of both sexes, responsible for one in four deaths.

Price: 919-829-4526

©2012 The News & Observer (Raleigh, N.C.)

Visit The News & Observer (Raleigh, N.C.) at www.newsobserver.com

There appears to be a significant connection between two of the deadliest human illnesses -- prostate cancer and heart disease -- suggesting that they may have the same causes, according to a new study led by Duke Cancer Institute researchers.

If further research shows that both diseases have the same triggers, it could mean that it's possible for men to reduce their risk of prostate cancer by making the straightforward, proven lifestyle changes for fighting heart disease, including improving diet, stopping smoking, reducing cholesterol levels and getting more exercise.

"That's obviously what's exciting to us about these results," said Dr. Stephen Freedland, an associate professor of surgery and pathology in the Division of Urology at Duke and senior author of the paper.

The study appears online this month in the journal Cancer Epidemiology, Biomarkers & Prevention.

Previous studies into a possible link between the two diseases have offered conflicting results. This time, researchers found that the correlation is real, Freedland said.

"It's not like every man in the study with heart disease had cancer," he said. "But we can say that clearly if you do have heart disease, your risk of prostate cancer is higher."

The researchers studied data from nearly 6,400 men who were enrolled in a large prostate drug trial. Of those, 547 reported a history of heart disease at the time they enrolled.

The men had prostate biopsies to test for cancer two years and four years into the study. Using results from those biopsies, the researchers found that having coronary artery disease increased the risk of prostate cancer by 35 percent averaged over the four-year study. That risk increased over time.

The study is not ideal, in part because it relied on data from an unrelated drug trial. In addition, the results simply show a link, pointing the way to further research into questions such as whether heart disease can somehow cause prostate cancer.

Still, the implications carry unusual weight because both diseases are major killers. Cancer of the prostate is the second-leading cause of cancer deaths among men, while heart disease is the single greatest killer of adults of both sexes, responsible for one in four deaths.

Price: 919-829-4526

©2012 The News & Observer (Raleigh, N.C.)

Visit The News & Observer (Raleigh, N.C.) at www.newsobserver.com

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Statins May Raise Diabetes Risk

Posted Feb 6, 2012

A new side effect seems to be emerging for those cholesterol-lowering wonder drugs called statins: They may increase some people’s chances of developing Type 2 diabetes.

A study published Monday adds to the evidence, finding a modest risk among older women who used a variety of statins.

It’s a puzzling link, and specialists say people who most need statins because of a high risk for a heart attack should stick with the drugs.

“What I fear here is that people who need and will benefit from statins will be scared off of using the drugs because of reports like this,” says Dr. Steven Nissen, cardiology chairman at the Cleveland Clinic, who wasn’t involved with the research. “We don’t want these drugs in the water supply, but we want the right people treated. When they are, this effect is not a significant limitation.”

But more and more doctors are urging otherwise healthy people to use the pills as a way to prevent heart disease. For them, the findings add another potential complication as they consider whether to tackle their cholesterol with diet and exercise alone or add a medication.

“The statin should not be seen as the magic pill,” says Dr. Yunsheng Ma of the University of Massachusetts Medical School, who led the study of postmenopausal women.

Statins are one of the most widely prescribed drugs, and among the most touted with good reason. They can dramatically lower so-called “bad” LDL cholesterol. Studies make clear that they save lives when used by people who already have heart disease.

What’s debated is how much the drugs help people who don’t yet have cardiovascular disease but whose chances are higher because of other factors such as smoking or high blood pressure – or diabetes. In fact, long-term diabetes is so heart-risky that the American Diabetes Association urges fairly aggressive statin use by many diabetics. For everyone else, Nissen says the general rule is statins help people who have at least a 10 percent chance of a heart attack in the next 10 years, something a doctor can calculate.

All drugs have side effects that are important to consider while deciding whether they’re a good bet for an individual. Statins have long been known to cause muscle pain that on rare occasions becomes a serious breakdown of muscle that can lead to kidney failure, even death.

But whether statins can make blood sugar rise enough that someone crosses the threshold to diabetes has been confusing.

After all, some of the same risks for heart disease – such as being overweight and sedentary – also increase the odds of developing Type 2 diabetes. And Ma says too many statin users wrongly assume the pills will let them eat whatever they want.

Ma’s team examined a huge government study that tracked the health of postmenopausal women for many years. They culled the records of more than 153,000 women who didn’t have diabetes when they enrolled in the Women’s Health Initiative in the 1990s. Just 7 percent were taking statins at the time.

Fast forward to 2005: Nearly 10 percent of the statin users had developed diabetes, compared with 6.4 percent of the older women who hadn’t used the drugs at the study’s start, Ma concluded. The findings were reported online Monday by the journal Archives of Internal Medicine.

This is what scientists call an observational study, which can hint at a risk but can’t prove it.

But it comes after a number of smaller but more precise studies – where patients were randomly assigned to take a statin or some other treatment – that also have found a link. The first to prompt doctor head-scratching was in 2008, a study of the drug Crestor. Last June, a report in the Journal of the American Medical Association analyzed five additional randomized trials and concluded the increased risk was small but real for people taking higher doses of any statin.

That report calculated that one fewer patient would experience a heart attack or other cardiovascular problem for every 155 patients treated for a year – and there would be one additional case of diabetes for every 498 patients treated.

At the National Institutes of Health, diabetes specialist Dr. Judith Fradkin says statins’ benefits outweigh the potential side effect, and that newly developed diabetes won’t harm right away.

“The danger here is alarming people and having them go off a medication that’s of proven benefit,” she says.

But Dr. Beatrice Golomb of the University of California, San Diego, welcomed the new study as a needed note of caution for women, saying there’s less certainty about the drugs’ overall effects in them. Stay tuned: Her own research aims to narrow down which statin users are more likely to experience a blood-sugar jump.

EDITOR’S NOTE – Lauran Neergaard covers health and medical issues for The Associated Press in Washington.

A new side effect seems to be emerging for those cholesterol-lowering wonder drugs called statins: They may increase some people's chances of developing Type 2 diabetes.

A study published Monday adds to the evidence, finding a modest risk among older women who used a variety of statins.

It's a puzzling link, and specialists say people who most need statins because of a high risk for a heart attack should stick with the drugs.

"What I fear here is that people who need and will benefit from statins will be scared off of using the drugs because of reports like this," says Dr. Steven Nissen, cardiology chairman at the Cleveland Clinic, who wasn't involved with the research. "We don't want these drugs in the water supply, but we want the right people treated. When they are, this effect is not a significant limitation."

But more and more doctors are urging otherwise healthy people to use the pills as a way to prevent heart disease. For them, the findings add another potential complication as they consider whether to tackle their cholesterol with diet and exercise alone or add a medication.

"The statin should not be seen as the magic pill," says Dr. Yunsheng Ma of the University of Massachusetts Medical School, who led the study of postmenopausal women.

Statins are one of the most widely prescribed drugs, and among the most touted with good reason. They can dramatically lower so-called "bad" LDL cholesterol. Studies make clear that they save lives when used by people who already have heart disease.

What's debated is how much the drugs help people who don't yet have cardiovascular disease but whose chances are higher because of other factors such as smoking or high blood pressure - or diabetes. In fact, long-term diabetes is so heart-risky that the American Diabetes Association urges fairly aggressive statin use by many diabetics. For everyone else, Nissen says the general rule is statins help people who have at least a 10 percent chance of a heart attack in the next 10 years, something a doctor can calculate.

All drugs have side effects that are important to consider while deciding whether they're a good bet for an individual. Statins have long been known to cause muscle pain that on rare occasions becomes a serious breakdown of muscle that can lead to kidney failure, even death.

But whether statins can make blood sugar rise enough that someone crosses the threshold to diabetes has been confusing.

After all, some of the same risks for heart disease - such as being overweight and sedentary - also increase the odds of developing Type 2 diabetes. And Ma says too many statin users wrongly assume the pills will let them eat whatever they want.

Ma's team examined a huge government study that tracked the health of postmenopausal women for many years. They culled the records of more than 153,000 women who didn't have diabetes when they enrolled in the Women's Health Initiative in the 1990s. Just 7 percent were taking statins at the time.

Fast forward to 2005: Nearly 10 percent of the statin users had developed diabetes, compared with 6.4 percent of the older women who hadn't used the drugs at the study's start, Ma concluded. The findings were reported online Monday by the journal Archives of Internal Medicine.

This is what scientists call an observational study, which can hint at a risk but can't prove it.

But it comes after a number of smaller but more precise studies - where patients were randomly assigned to take a statin or some other treatment - that also have found a link. The first to prompt doctor head-scratching was in 2008, a study of the drug Crestor. Last June, a report in the Journal of the American Medical Association analyzed five additional randomized trials and concluded the increased risk was small but real for people taking higher doses of any statin.

That report calculated that one fewer patient would experience a heart attack or other cardiovascular problem for every 155 patients treated for a year - and there would be one additional case of diabetes for every 498 patients treated.

At the National Institutes of Health, diabetes specialist Dr. Judith Fradkin says statins' benefits outweigh the potential side effect, and that newly developed diabetes won't harm right away.

"The danger here is alarming people and having them go off a medication that's of proven benefit," she says.

But Dr. Beatrice Golomb of the University of California, San Diego, welcomed the new study as a needed note of caution for women, saying there's less certainty about the drugs' overall effects in them. Stay tuned: Her own research aims to narrow down which statin users are more likely to experience a blood-sugar jump.

EDITOR'S NOTE - Lauran Neergaard covers health and medical issues for The Associated Press in Washington.

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Heart Awareness Month

Posted Feb 4, 2012

February is Heart Awareness Month, and Friday marks National Wear Red Day to raise awareness about heart disease, such as how to recognize it, treat it and prevent it.

Heart disease is the No. 1 killer of women, according to the American Heart Association.

Jean Julius, a registered nurse with the Owensboro Medical Health System HealthPark, said a person can improve heart health by not smoking, avoiding secondhand smoke, staying active by walking every day and eating a healthy, balanced diet with less salt.

“You should also check your blood pressure often,” Julius said. “If you’re on blood pressure medicine, then a physician checks you regularly. Other than that, get it checked once a year, but as we age, the blood pressure goes higher.”

Recommended blood pressure is 120 over 80.

According to the AHA, more women now die from coronary disease in the United States each year than do men. One theory is that the disease has progressed further without a woman being aware of it. Women, historically, don’t visit cardiologists as much as men.

“Men have that heavy feeling in their chest, like an elephant is sitting on it,” Julius said. “That’s not always true with women. They feel tired, fatigued and a shortness of breath.

“Women may feel nauseated or an ache in the chest. They think that’s indigestion, which men do also. And just like in men, the pain radiates to the jaw, neck and shoulders. That’s a sign that you should respond right away.”

At that point, a person should call 911 and not go to a clinic.

“As soon as EMT’s arrive, they’ll be in communication with the emergency room,” Julius said. “When you get there, there will be no waiting in the waiting room, you’ll be seen immediately.”

Julius said it’s better to be on the safe side and go to the ER and find out you didn’t have a heart attack than not going when you did have one. Blockages prevent oxygen in the blood from getting where it needs to go.

“The lack of circulation of blood to the heart muscle is what’s causing the pain,” she said.

Women also tend to have higher cholesterol than men. Additionally, high triglycerides tend to more negatively affect women in terms of causing blockages and heart attacks.

Fat in the artery is called plaque, and plaque adheres to an artery wall, building up and slowly eroding into the artery. Women are more prone to erosion, meaning the plaque erodes into the bloodstream, creating the likelihood that it will lodge somewhere to cause a blood clot, and block the blood flow, causing a heart attack.

Rich Suwanski, 691-7315

©2012 the Messenger-Inquirer (Owensboro, Ky.)

Visit the Messenger-Inquirer (Owensboro, Ky.) at www.messenger-inquirer.com

Distributed by MCT Information Services

February is Heart Awareness Month, and Friday marks National Wear Red Day to raise awareness about heart disease, such as how to recognize it, treat it and prevent it.

Heart disease is the No. 1 killer of women, according to the American Heart Association.

Jean Julius, a registered nurse with the Owensboro Medical Health System HealthPark, said a person can improve heart health by not smoking, avoiding secondhand smoke, staying active by walking every day and eating a healthy, balanced diet with less salt.

"You should also check your blood pressure often," Julius said. "If you're on blood pressure medicine, then a physician checks you regularly. Other than that, get it checked once a year, but as we age, the blood pressure goes higher."

Recommended blood pressure is 120 over 80.

According to the AHA, more women now die from coronary disease in the United States each year than do men. One theory is that the disease has progressed further without a woman being aware of it. Women, historically, don't visit cardiologists as much as men.

"Men have that heavy feeling in their chest, like an elephant is sitting on it," Julius said. "That's not always true with women. They feel tired, fatigued and a shortness of breath.

"Women may feel nauseated or an ache in the chest. They think that's indigestion, which men do also. And just like in men, the pain radiates to the jaw, neck and shoulders. That's a sign that you should respond right away."

At that point, a person should call 911 and not go to a clinic.

"As soon as EMT's arrive, they'll be in communication with the emergency room," Julius said. "When you get there, there will be no waiting in the waiting room, you'll be seen immediately."

Julius said it's better to be on the safe side and go to the ER and find out you didn't have a heart attack than not going when you did have one. Blockages prevent oxygen in the blood from getting where it needs to go.

"The lack of circulation of blood to the heart muscle is what's causing the pain," she said.

Women also tend to have higher cholesterol than men. Additionally, high triglycerides tend to more negatively affect women in terms of causing blockages and heart attacks.

Fat in the artery is called plaque, and plaque adheres to an artery wall, building up and slowly eroding into the artery. Women are more prone to erosion, meaning the plaque erodes into the bloodstream, creating the likelihood that it will lodge somewhere to cause a blood clot, and block the blood flow, causing a heart attack.

Rich Suwanski, 691-7315

©2012 the Messenger-Inquirer (Owensboro, Ky.)

Visit the Messenger-Inquirer (Owensboro, Ky.) at www.messenger-inquirer.com



Distributed by MCT Information Services

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Dr Encourages Action to Tackle Obesity Epidemic

Posted Jan 25, 2011

Join together, grab some sandbags, stack them on the levy and don’t get overwhelmed. Nobody has to stop the incoming flood by themselves, but everyone’s got to contribute to a sustained effort.

That’s the message Dr. David Katz, founding director of Yale University’s Prevention Research Center and nationally known public health and nutrition columnist and celebrity, delivered to about 150 local health and social services leaders last week in what turned into a kind of call to arms.

The incoming flood that threatens our society’s wellbeing both physically and financially, due to rising health care costs, is the “dire crisis” of childhood and adult obesity that is responsible for up to 80 percent of cases of premature death from heart attack, diabetes, stroke and cancer, he said. When he asked people in the room to raise their hands if they had loved someone who died prematurely of one of these illnesses, nearly all hands went up. Some wiped away tears.

“But if we come together and are willing to cross over to do what it takes to turn knowledge into power, we could bequeath our children lives not touched by this,” Katz, 49, who lives in Hamden, said in a phone interview after his talk. “The knowledge is clear — we need to make better use of our feet, forks and fingers (with regular exercise, better diets and no smoking habit). I don’t need more data. There is a solution. If a building is on fire you don’t need a randomized clinical trial to tell you that you should fetch a pail of water.”

Katz spoke last week to the first joint meeting of three groups, the New London County Food Policy Council, the New London County Health Collaborative and Children First Southeastern Connecticut. All three have identified obesity and poor nutrition as key problems they want to address. After his talk, representatives of the groups stayed to discuss the activities currently going on in the region focusing on these problems and ways to work together on new or expanded initiatives.

“It was very motivational,” said Nancy Cowser, vice president of planning for United Community and Family Service in Norwich and a member of the food policy council. “I felt like I got slapped in the face in a good way.”

Keith Fontaine, vice president of corporate communications at The William W. Backus Hospital in Norwich and co-chairman of the food council, said those at the talk have begun meeting to leverage the inspiration they received from Katz to build on the work already being done. Goals already set by the food council, he said, include:

–completing an analysis of the food system in New London County and how to improve it. It would identify, among other characteristics, the “food deserts,” where low-income and third-shift workers have poor access to fresh produce and nutritious foods.

–an assessment of emergency food pantries that includes who receives the food and how often, and the quality of the food. Giving poor people food that’s poor in nutrition “is not really helping the situation,” but only setting more people up for diet-related illnesses, Fontaine said. Cooking classes may also be needed.

–creating programs specifically targeted to obesity-related diabetes, which can also trigger heart disease and cancer.

Fontaine and others at Katz’s talk have been well aware of the obesity problem — Fontaine noted that a recent community health survey by Backus revealed that eastern Connecticut had higher rates than the rest of the state. But his message served as a stark reminder of the consequences of ignoring it, or losing enthusiasm for tackling it.

“By the middle of this century, one in three Americans will have diabetes (unless the trend is reversed). We can’t afford that,” Fontaine said, referring to one of the statistics shared by Katz. “This forced us to think of the enormity of the problem. A lot of light bulbs went off.”

Several who heard Katz’s talk were inspired by some of his practical, low-cost solutions. Laurel Holmes, director of community outreach and partnerships at Lawrence & Memorial Hospital in New London, recalled his suggestion that classroom teachers incorporate five-minute “activity bursts” periodically throughout the day. These are simple exercises students can do at their desks, and, she noted, research cited by Katz shows doing them regularly increases students’ academic achievement and improves behavior. The routine can also be adopted to office settings.

Others recalled his message that nutritious food doesn’t necessarily cost more than junk food. It’s more a matter of teaching people how to identify and prepare nutritious foods, and encouraging them to make good choices. Katz believes the millions spent by the federal government on health care for illnesses related to obesity and poor diets could be reduced significantly if the federal food stamp program included incentives for recipients to make healthy choices.

“We’re squandering our resources,” he said.

Sherry Filiatreault, coordinator of Children First Norwich and one of the organizers of the event, was also excited to learn about the NuVal nutrition rating system developed by Katz. Her group became concerned about the obesity issue after it compiled 2010 statistics showing that 43 percent of the sixth-graders in Norwich are overweight or obese.

The NuVal system, in use at 23 grocery store chains across the country, gives products a one to 100 rating for nutritional value, with 100 being the best. At Big Y, the only local chain using NuVal, the number is displayed on the store shelves next to the product, on the same sign with the unit price and item price. It’s an easy tool consumers can use to make good choices, Filiatreault said.

“The NuVal system takes the guesswork out of knowing which item to buy,” Filiatreault said.

At Big Y, which has local stores in Groton, Mystic, Norwich and Old Lyme, more than 50 percent of items have a NuVal number, said Carrie Taylor, registered dietitian for Big Y Foods. The chain began displaying NuVal scores a year ago. Thus far, customer response has been positive, she said.

“We’re constantly getting updates and getting more things scored every month,” she said.

Katz said the NuVal system has been available to stores since 2008. A team of 15 dietitians develops the score for each food based on the amounts of 30 nutrients and also factors in the quantity of protein, fat, carbohydrates, calories and omega-3 fats. Amounts of sugar, salt, trans fat, saturated fat and cholesterol are counted in to lower the score.

“Manufacturers who make foods that score poorly don’t like this truth meter,” Katz said. “But products are being reformulated in response. The long-term intent is to make changes in our food system.”

j.benson@theday.com

___

©2012 The Day (New London, Conn.)

Join together, grab some sandbags, stack them on the levy and don't get overwhelmed. Nobody has to stop the incoming flood by themselves, but everyone's got to contribute to a sustained effort.

That's the message Dr. David Katz, founding director of Yale University's Prevention Research Center and nationally known public health and nutrition columnist and celebrity, delivered to about 150 local health and social services leaders last week in what turned into a kind of call to arms.

The incoming flood that threatens our society's wellbeing both physically and financially, due to rising health care costs, is the "dire crisis" of childhood and adult obesity that is responsible for up to 80 percent of cases of premature death from heart attack, diabetes, stroke and cancer, he said. When he asked people in the room to raise their hands if they had loved someone who died prematurely of one of these illnesses, nearly all hands went up. Some wiped away tears.

"But if we come together and are willing to cross over to do what it takes to turn knowledge into power, we could bequeath our children lives not touched by this," Katz, 49, who lives in Hamden, said in a phone interview after his talk. "The knowledge is clear -- we need to make better use of our feet, forks and fingers (with regular exercise, better diets and no smoking habit). I don't need more data. There is a solution. If a building is on fire you don't need a randomized clinical trial to tell you that you should fetch a pail of water."

Katz spoke last week to the first joint meeting of three groups, the New London County Food Policy Council, the New London County Health Collaborative and Children First Southeastern Connecticut. All three have identified obesity and poor nutrition as key problems they want to address. After his talk, representatives of the groups stayed to discuss the activities currently going on in the region focusing on these problems and ways to work together on new or expanded initiatives.

"It was very motivational," said Nancy Cowser, vice president of planning for United Community and Family Service in Norwich and a member of the food policy council. "I felt like I got slapped in the face in a good way."

Keith Fontaine, vice president of corporate communications at The William W. Backus Hospital in Norwich and co-chairman of the food council, said those at the talk have begun meeting to leverage the inspiration they received from Katz to build on the work already being done. Goals already set by the food council, he said, include:

--completing an analysis of the food system in New London County and how to improve it. It would identify, among other characteristics, the "food deserts," where low-income and third-shift workers have poor access to fresh produce and nutritious foods.

--an assessment of emergency food pantries that includes who receives the food and how often, and the quality of the food. Giving poor people food that's poor in nutrition "is not really helping the situation," but only setting more people up for diet-related illnesses, Fontaine said. Cooking classes may also be needed.

--creating programs specifically targeted to obesity-related diabetes, which can also trigger heart disease and cancer.

Fontaine and others at Katz's talk have been well aware of the obesity problem -- Fontaine noted that a recent community health survey by Backus revealed that eastern Connecticut had higher rates than the rest of the state. But his message served as a stark reminder of the consequences of ignoring it, or losing enthusiasm for tackling it.

"By the middle of this century, one in three Americans will have diabetes (unless the trend is reversed). We can't afford that," Fontaine said, referring to one of the statistics shared by Katz. "This forced us to think of the enormity of the problem. A lot of light bulbs went off."

Several who heard Katz's talk were inspired by some of his practical, low-cost solutions. Laurel Holmes, director of community outreach and partnerships at Lawrence & Memorial Hospital in New London, recalled his suggestion that classroom teachers incorporate five-minute "activity bursts" periodically throughout the day. These are simple exercises students can do at their desks, and, she noted, research cited by Katz shows doing them regularly increases students' academic achievement and improves behavior. The routine can also be adopted to office settings.

Others recalled his message that nutritious food doesn't necessarily cost more than junk food. It's more a matter of teaching people how to identify and prepare nutritious foods, and encouraging them to make good choices. Katz believes the millions spent by the federal government on health care for illnesses related to obesity and poor diets could be reduced significantly if the federal food stamp program included incentives for recipients to make healthy choices.

"We're squandering our resources," he said.

Sherry Filiatreault, coordinator of Children First Norwich and one of the organizers of the event, was also excited to learn about the NuVal nutrition rating system developed by Katz. Her group became concerned about the obesity issue after it compiled 2010 statistics showing that 43 percent of the sixth-graders in Norwich are overweight or obese.

The NuVal system, in use at 23 grocery store chains across the country, gives products a one to 100 rating for nutritional value, with 100 being the best. At Big Y, the only local chain using NuVal, the number is displayed on the store shelves next to the product, on the same sign with the unit price and item price. It's an easy tool consumers can use to make good choices, Filiatreault said.

"The NuVal system takes the guesswork out of knowing which item to buy," Filiatreault said.

At Big Y, which has local stores in Groton, Mystic, Norwich and Old Lyme, more than 50 percent of items have a NuVal number, said Carrie Taylor, registered dietitian for Big Y Foods. The chain began displaying NuVal scores a year ago. Thus far, customer response has been positive, she said.

"We're constantly getting updates and getting more things scored every month," she said.

Katz said the NuVal system has been available to stores since 2008. A team of 15 dietitians develops the score for each food based on the amounts of 30 nutrients and also factors in the quantity of protein, fat, carbohydrates, calories and omega-3 fats. Amounts of sugar, salt, trans fat, saturated fat and cholesterol are counted in to lower the score.

"Manufacturers who make foods that score poorly don't like this truth meter," Katz said. "But products are being reformulated in response. The long-term intent is to make changes in our food system."

j.benson@theday.com

___

©2012 The Day (New London, Conn.)

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Stay Healthy in Each Decade of Life

Posted Jan 18, 2012

To keep your car running for as long as possible you have to treat it properly: service at regular intervals, use quality fuels and keep it clean.

So why would you treat your body, itself the ultimate machine, any less carefully?

Alas, too many of us do. A recent University of Miami study found that heart disease risk factors, such as high cholesterol levels and artery inflammation, can start as early as age 3.

In the United States, 19 percent of children 2 to 18 are obese and 30 percent are overweight, according to the U.S. Centers for Disease Control and Prevention.

“By the fourth grade, 13 percent of American children already have abnormally elevated cholesterol, with a total cholesterol of 200 or higher,” said Dr. Steven E. Lipshultz, one of the study’s authors and the chairman of the pediatrics department at the University of Miami Miller School of Medicine. The numbers are disproportionately higher among Hispanic and African-American children who tended to have higher inflammation levels and lower levels of HDL, the “good” cholesterol.

“There are three really important pieces that go into exercising across the ages from childhood to the 90s: the need to do aerobics, strengthening and stretching exercises,” said Dr. Neva Kirk-Sanchez, an associate professor in the department of physical therapy at the University of Miami.

Here, then, is a lifetime guide to good health.

Birth-9

Good nutrition begins at birth.

— Breast feed your newborn.

“In long-term studies, breast feeding truly does benefit children, including lowering cholesterol levels and having lower weight and a lower prevalence of Type 2 diabetes.”

The official recommendation is to breast feed baby for the first year, with breast milk the exclusive source of nourishment for the first six months.

— Limit fat to 30 percent of a child’s total calories after age 2. After age 2, switch from whole milk to non-fat milk and have your toddler drink lots of water.

— Limit fruit juices, even 100-percent fruit juices, to no more than four ounces per day for ages 2-21.

–Trans fats should be avoided and TV time should be limited to one to two hours “of quality programming” per day, he said. “Avoid ever putting a TV in a child’s bedroom.”

— Lower sodium intake. “It’s never too early to limit sodium in a child’s diet,” Lipshultz said. “Elevated blood pressure is a major contributor to heart disease.”

— Begin blood pressure checks at age 3.

— Tests to screen for cholesterol should begin by age 9 to 11 and again at 17 for all children.

Children and adolescents should have at least one hour or more of physical exercise every day, according to the Centers for Disease Control and Prevention. Aerobic activity such as running, brisk walking and playing sports should make up the majority of the exercise.

Children 10 and under don’t need formal muscle strengthening programs, such as weight lifting, as the development of muscles begins at puberty, but muscle strengthening should be done via fun activities, such as playing on the jungle gym, swimming or gymnastics.

10-19

— Exercise, exercise, exercise — at least an hour daily, and include bone strengthening activities such as jumping rope and running games like tag or sports.

“Ninety percent of bone mass is acquired by girls by 19 and boys by 20, so childhood and early adolescence is the most important time for building bone health,” Lipshultz said. “Physical activity patterns established in childhood are carried forward in adulthood. Exercising and unlimited playtime will incorporate lifelong habits that will help the child live longer.”

— Start weight training at around age 14 or the onset of puberty, said Garrett Ratleff, personal training manager for South Beach’s Crunch. “Supervised weight training will have an effect on their body, especially if they are playing sports,” he said.

— Monitor diets. This is a time when children begin making some of their own food choices and salts, fats and sugars are tasty temptations that can lead to trouble.

“Encourage whole foods high in dietary fiber — brown rice, oatmeal, popcorn and encourage fresh fruit and vegetables at every meal,” Lipshultz said. “If you are concerned that your child is overweight, don’t wait until the next checkup to discuss ways to improve a child’s weight and diet and activity levels.”

–Don’t begin smoking and avoid smoke, period. Exposure contributes to heart and lung disease.

20-29

— The Cars had it right: Shake it up. “This is a time you should be exploring and trying different types of workouts,” Ratleff said. “At 20, your body is resilient, you don’t have to worry about injuring yourself as much.”

This is the time to consider that 5K, half marathon or full marathon. Three to six days a week of moderate to intensive aerobic activity for 20 to 60 minutes should be a goal, along with two to five days of strength training.

— Work all the major muscle groups, the legs, hips, back, abdomen, chest, shoulders and arms. If you can’t afford a gym, or class, then run, swim, bike, dance, or walk briskly around the neighborhood. Push-ups, crunches, squats and other strength activities can be done around the house or in the office. Find a wall and push against it or do dips from the back of your chair.

If you can do more than 300 minutes a week of moderate intensity activity or 150 minutes of vigorous activity you should see improvements in health.

— If you have a disability, consult with a doctor or physical therapist to see what kind of activities are suitable for you. You can also visit the National Center on Physical Activity and Disability at www.ncpad.org.

30-39

Careers and raising children often get in the way of an exercise program but there are ways around the obstacle.

— “Be more efficient in your workouts in the gym, or wherever you do it,” Ratleff recommends. Interval training — sets with multiple reps and tempo — works all the muscle groups and gets the heart rate up in an hour’s time.

— Consider classes, like a boot camp, dance, step, Pilates, kickboxing or any other creative group workout. A Masters swimming group is another fun option.

“The social support in these groups is very helpful,” Kirk-Sanchez said.

— Women should absolutely begin a weight-lifting program, or some other form of strength resistance training, in this decade if they haven’t done so during their 20s to ward off bone density loss, which starts about this time.

“Osteoporosis is a risk so if you want to delay that, start weight training,” Ratleff said.

— If you haven’t begun regular dental visits, which generally suggests twice-yearly cleanings and exams, begin now. The American Dental Association has identified an association between maternal periodontal disease and preterm delivery, preeclampsia and low birth weight infants. Later, periodontal disease can lead to cardiovascular disease.

40-49

— Stretching becomes more important as flexibility lessens. Devote more time to warming up and the post-workout stretch, Kirk-Sanchez suggests. “Don’t just walk out the door and sprint down the street. You need to adapt to the aging body and warm up,” she said.

Avoid injuries. “When you are 40 and injured you can be out for a month; in your 20s, you’re usually out for a week,” Ratleff said. Consider a certified trainer in the gym.

— Workout videos are another option for those who need some guidance but like to work out in the home. Jane Fonda, who launched the home video workout revolution in the ’80s with her tapes, is back with a new series of Prime Time DVDs that offer toning, sculpting and stretching routines designed for adults. The Dancing With the Stars pros also have DVD workouts, including one that promises Ballroom Buns & Abs.

— For women, it’s the pre-menopause period. Estrogen levels start to drop and fat storage around the abdomen goes up. Strength training and cardio remain important. For men, lean muscle mass is good for posture and a boost in the metabolism.

50-59

— If beginning an exercise program, “Start slowly and listen to the body if anything painful needs to be addressed,” Kirk-Sanchez said. Maintain at least 30 minutes of moderate activity daily and strengthening two to three days per week.

Tissues tend to get less flexible with age. Chronic problems like arthritis and obesity are often felt at this time but it is not too late to begin a program. “People very easily take the medications their doctor prescribes but are much less eager to do exercise.

“For all the chronic conditions exercise is known to prevent, you have to consider the exercise prescription just as important as taking your pills,” she said.

— Break it up. While 30 minutes of sustained moderate to vigorous activity is best in the younger years, at this stage you can break up the activities into 10-minute blocks. A brisk 10-minute walk, three times a day, five days a week, will help you hit the required 150 minutes of moderate intensity exercise.

60-69

— The retirement years (for some) lead to more time for exercise. Circuit training, swimming, cardio walking are good options, along with resistance training. Resistance bands are as viable as weights if you don’t have access to a gym.

Stretching, longer warm-ups and safety is paramount.

— Balance exercises should be added to the program. Stand on one leg, practice walking on a line or navigate through an obstacle course. Tai-Chi and yoga classes are great options for balance exercises.

“All of the sensory systems tend to decline a little in the older population, but maintaining good muscles and a healthy nervous system is much easier in those who exercise regularly,” Kirk-Sanchez said.

70-79

— Don’t forget the trunk. The core muscle group in the abdomen area helps the body maintain balance and accomplish tasks, like rising from the bed or a chair. “When older people have trouble getting out of bed that’s generally because abdominal and hip strength has declined — it’s the Use it or Lose It philosophy,” Kirk-Sanchez said.

Modified sit-ups, while seated in a chair, or crunches could help tone the tummy and help with balance.

— Forget cultural fallacies. “In Hispanic women, especially, they feel as they get older they shouldn’t exercise, but the opposite is true. They must exercise to fend off chronic diseases that come up, such as osteoporosis and diabetes,” Kirk-Sanchez said.

80 and older

— The same lessons apply. Exercise. Ratleff recalled an instructor who once counseled, “You’re never too old to do a squat.”

“You see seniors who are hunched over, posture will go quickly if you lose muscle mass and bone density,” he said.

— Consider two days of low-impact exercise, like walking or Tai-Chi. A half hour of circuit training. Trunk rotations to keep the body limber to ward off injuries from falls, which can be life-threatening.

— Many hospitals and centers offer free exercise programs, such as Baptist Health’s mall walkers program at Dadeland Mall which incorporates activities like stretching and toning exercises to music with group walking.

“Even in the 90s people can make big improvements in their ability to get up and walk around,” Kirk-Sanchez said. “Exercise has an effect on cognition, normal aging memory. It’s not only the blood flow, but the biochemistry in the brain. There are changes in the brain in response to exercise across the life span.”

©2012 The Miami Herald

Visit The Miami Herald at www.miamiherald.com

To keep your car running for as long as possible you have to treat it properly: service at regular intervals, use quality fuels and keep it clean.

So why would you treat your body, itself the ultimate machine, any less carefully?

Alas, too many of us do. A recent University of Miami study found that heart disease risk factors, such as high cholesterol levels and artery inflammation, can start as early as age 3.

In the United States, 19 percent of children 2 to 18 are obese and 30 percent are overweight, according to the U.S. Centers for Disease Control and Prevention.

"By the fourth grade, 13 percent of American children already have abnormally elevated cholesterol, with a total cholesterol of 200 or higher," said Dr. Steven E. Lipshultz, one of the study's authors and the chairman of the pediatrics department at the University of Miami Miller School of Medicine. The numbers are disproportionately higher among Hispanic and African-American children who tended to have higher inflammation levels and lower levels of HDL, the "good" cholesterol.

"There are three really important pieces that go into exercising across the ages from childhood to the 90s: the need to do aerobics, strengthening and stretching exercises," said Dr. Neva Kirk-Sanchez, an associate professor in the department of physical therapy at the University of Miami.

Here, then, is a lifetime guide to good health.

Birth-9

Good nutrition begins at birth.

-- Breast feed your newborn.

"In long-term studies, breast feeding truly does benefit children, including lowering cholesterol levels and having lower weight and a lower prevalence of Type 2 diabetes."

The official recommendation is to breast feed baby for the first year, with breast milk the exclusive source of nourishment for the first six months.

-- Limit fat to 30 percent of a child's total calories after age 2. After age 2, switch from whole milk to non-fat milk and have your toddler drink lots of water.

-- Limit fruit juices, even 100-percent fruit juices, to no more than four ounces per day for ages 2-21.

--Trans fats should be avoided and TV time should be limited to one to two hours "of quality programming" per day, he said. "Avoid ever putting a TV in a child's bedroom."

-- Lower sodium intake. "It's never too early to limit sodium in a child's diet," Lipshultz said. "Elevated blood pressure is a major contributor to heart disease."

-- Begin blood pressure checks at age 3.

-- Tests to screen for cholesterol should begin by age 9 to 11 and again at 17 for all children.

Children and adolescents should have at least one hour or more of physical exercise every day, according to the Centers for Disease Control and Prevention. Aerobic activity such as running, brisk walking and playing sports should make up the majority of the exercise.

Children 10 and under don't need formal muscle strengthening programs, such as weight lifting, as the development of muscles begins at puberty, but muscle strengthening should be done via fun activities, such as playing on the jungle gym, swimming or gymnastics.

10-19

-- Exercise, exercise, exercise -- at least an hour daily, and include bone strengthening activities such as jumping rope and running games like tag or sports.

"Ninety percent of bone mass is acquired by girls by 19 and boys by 20, so childhood and early adolescence is the most important time for building bone health," Lipshultz said. "Physical activity patterns established in childhood are carried forward in adulthood. Exercising and unlimited playtime will incorporate lifelong habits that will help the child live longer."

-- Start weight training at around age 14 or the onset of puberty, said Garrett Ratleff, personal training manager for South Beach's Crunch. "Supervised weight training will have an effect on their body, especially if they are playing sports," he said.

-- Monitor diets. This is a time when children begin making some of their own food choices and salts, fats and sugars are tasty temptations that can lead to trouble.

"Encourage whole foods high in dietary fiber -- brown rice, oatmeal, popcorn and encourage fresh fruit and vegetables at every meal," Lipshultz said. "If you are concerned that your child is overweight, don't wait until the next checkup to discuss ways to improve a child's weight and diet and activity levels."

--Don't begin smoking and avoid smoke, period. Exposure contributes to heart and lung disease.

20-29

-- The Cars had it right: Shake it up. "This is a time you should be exploring and trying different types of workouts," Ratleff said. "At 20, your body is resilient, you don't have to worry about injuring yourself as much."

This is the time to consider that 5K, half marathon or full marathon. Three to six days a week of moderate to intensive aerobic activity for 20 to 60 minutes should be a goal, along with two to five days of strength training.

-- Work all the major muscle groups, the legs, hips, back, abdomen, chest, shoulders and arms. If you can't afford a gym, or class, then run, swim, bike, dance, or walk briskly around the neighborhood. Push-ups, crunches, squats and other strength activities can be done around the house or in the office. Find a wall and push against it or do dips from the back of your chair.

If you can do more than 300 minutes a week of moderate intensity activity or 150 minutes of vigorous activity you should see improvements in health.

-- If you have a disability, consult with a doctor or physical therapist to see what kind of activities are suitable for you. You can also visit the National Center on Physical Activity and Disability at www.ncpad.org.

30-39

Careers and raising children often get in the way of an exercise program but there are ways around the obstacle.

-- "Be more efficient in your workouts in the gym, or wherever you do it," Ratleff recommends. Interval training -- sets with multiple reps and tempo -- works all the muscle groups and gets the heart rate up in an hour's time.

-- Consider classes, like a boot camp, dance, step, Pilates, kickboxing or any other creative group workout. A Masters swimming group is another fun option.

"The social support in these groups is very helpful,'' Kirk-Sanchez said.

-- Women should absolutely begin a weight-lifting program, or some other form of strength resistance training, in this decade if they haven't done so during their 20s to ward off bone density loss, which starts about this time.

"Osteoporosis is a risk so if you want to delay that, start weight training," Ratleff said.

-- If you haven't begun regular dental visits, which generally suggests twice-yearly cleanings and exams, begin now. The American Dental Association has identified an association between maternal periodontal disease and preterm delivery, preeclampsia and low birth weight infants. Later, periodontal disease can lead to cardiovascular disease.

40-49

-- Stretching becomes more important as flexibility lessens. Devote more time to warming up and the post-workout stretch, Kirk-Sanchez suggests. "Don't just walk out the door and sprint down the street. You need to adapt to the aging body and warm up," she said.

Avoid injuries. "When you are 40 and injured you can be out for a month; in your 20s, you're usually out for a week," Ratleff said. Consider a certified trainer in the gym.

-- Workout videos are another option for those who need some guidance but like to work out in the home. Jane Fonda, who launched the home video workout revolution in the '80s with her tapes, is back with a new series of Prime Time DVDs that offer toning, sculpting and stretching routines designed for adults. The Dancing With the Stars pros also have DVD workouts, including one that promises Ballroom Buns & Abs.

-- For women, it's the pre-menopause period. Estrogen levels start to drop and fat storage around the abdomen goes up. Strength training and cardio remain important. For men, lean muscle mass is good for posture and a boost in the metabolism.

50-59

-- If beginning an exercise program, "Start slowly and listen to the body if anything painful needs to be addressed," Kirk-Sanchez said. Maintain at least 30 minutes of moderate activity daily and strengthening two to three days per week.

Tissues tend to get less flexible with age. Chronic problems like arthritis and obesity are often felt at this time but it is not too late to begin a program. "People very easily take the medications their doctor prescribes but are much less eager to do exercise.

"For all the chronic conditions exercise is known to prevent, you have to consider the exercise prescription just as important as taking your pills," she said.

-- Break it up. While 30 minutes of sustained moderate to vigorous activity is best in the younger years, at this stage you can break up the activities into 10-minute blocks. A brisk 10-minute walk, three times a day, five days a week, will help you hit the required 150 minutes of moderate intensity exercise.

60-69

-- The retirement years (for some) lead to more time for exercise. Circuit training, swimming, cardio walking are good options, along with resistance training. Resistance bands are as viable as weights if you don't have access to a gym.

Stretching, longer warm-ups and safety is paramount.

-- Balance exercises should be added to the program. Stand on one leg, practice walking on a line or navigate through an obstacle course. Tai-Chi and yoga classes are great options for balance exercises.

"All of the sensory systems tend to decline a little in the older population, but maintaining good muscles and a healthy nervous system is much easier in those who exercise regularly," Kirk-Sanchez said.

70-79

-- Don't forget the trunk. The core muscle group in the abdomen area helps the body maintain balance and accomplish tasks, like rising from the bed or a chair. "When older people have trouble getting out of bed that's generally because abdominal and hip strength has declined -- it's the Use it or Lose It philosophy," Kirk-Sanchez said.

Modified sit-ups, while seated in a chair, or crunches could help tone the tummy and help with balance.

-- Forget cultural fallacies. "In Hispanic women, especially, they feel as they get older they shouldn't exercise, but the opposite is true. They must exercise to fend off chronic diseases that come up, such as osteoporosis and diabetes," Kirk-Sanchez said.

80 and older

-- The same lessons apply. Exercise. Ratleff recalled an instructor who once counseled, "You're never too old to do a squat."

"You see seniors who are hunched over, posture will go quickly if you lose muscle mass and bone density," he said.

-- Consider two days of low-impact exercise, like walking or Tai-Chi. A half hour of circuit training. Trunk rotations to keep the body limber to ward off injuries from falls, which can be life-threatening.

-- Many hospitals and centers offer free exercise programs, such as Baptist Health's mall walkers program at Dadeland Mall which incorporates activities like stretching and toning exercises to music with group walking.

"Even in the 90s people can make big improvements in their ability to get up and walk around," Kirk-Sanchez said. "Exercise has an effect on cognition, normal aging memory. It's not only the blood flow, but the biochemistry in the brain. There are changes in the brain in response to exercise across the life span."

©2012 The Miami Herald

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Few Still Following Resolutions

Posted January 17, 2012

If you’re a woman who made a New Year’s resolution to lose weight and you’ve made it this far without falling off the diet bandwagon, give yourself a hearty pat on the back. You’re above average. If you’re a man, you need to hang tough — but not for much longer.

A poll financed by the insurance industry found that the average woman who resolves to lose weight makes it only until Jan. 6 before breaking that vow. Men do better, but not by a lot. They tend to keep their diet resolutions until Jan. 18.

It turns out that few New Year’s resolutions make it past the end of January. According to the researchers, men who resolve to give up drinking usually manage for about a week, while women go two weeks. If quitting smoking is your focus, women last an average of seven days before lighting up again, while men go 20 days.

The resolution that lasts the longest? Exercising. Men who vow to start following a fitness routine tend to stick with it for six weeks, which is about twice as long as women.

Don’t feel bad if you came up short. At least you tried. A survey conducted by the Marist Institute for Public Opinion in December found that 62 percent of Americans didn’t plan to make any resolutions for 2012.

And, as they say in sports, there’s always next year.

©2012 the Star Tribune (Minneapolis)



If you're a woman who made a New Year's resolution to lose weight and you've made it this far without falling off the diet bandwagon, give yourself a hearty pat on the back. You're above average. If you're a man, you need to hang tough -- but not for much longer.

A poll financed by the insurance industry found that the average woman who resolves to lose weight makes it only until Jan. 6 before breaking that vow. Men do better, but not by a lot. They tend to keep their diet resolutions until Jan. 18.

It turns out that few New Year's resolutions make it past the end of January. According to the researchers, men who resolve to give up drinking usually manage for about a week, while women go two weeks. If quitting smoking is your focus, women last an average of seven days before lighting up again, while men go 20 days.

The resolution that lasts the longest? Exercising. Men who vow to start following a fitness routine tend to stick with it for six weeks, which is about twice as long as women.

Don't feel bad if you came up short. At least you tried. A survey conducted by the Marist Institute for Public Opinion in December found that 62 percent of Americans didn't plan to make any resolutions for 2012.

And, as they say in sports, there's always next year.

©2012 the Star Tribune (Minneapolis)

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City Life May Decrease Male Fertility

Posted Jan 3, 2012

City living causes young Italian adults’ sperm count decrease, according to a new study by Italian Society of Andrology and Sexuality Medicine (SIAMS).

By pooling the results of three studies, the Rome-based organisation concluded that more than 33 percent of men between 18 and 20 years old suffer from a sever loss of sperm to such urban factors as pollution and smoking.

The study was financed by the Italian Health Ministry.

City life also promotes a sedentary lifestyle and obesity, also negatively impacts sperm count, according to SIAMS.

“It’s worth reminding youth because they are completely ignorant about the risk to fertility,” SIAMS said.

©2011 Adnkronos International (Rome)

City living causes young Italian adults' sperm count decrease, according to a new study by Italian Society of Andrology and Sexuality Medicine (SIAMS).

By pooling the results of three studies, the Rome-based organisation concluded that more than 33 percent of men between 18 and 20 years old suffer from a sever loss of sperm to such urban factors as pollution and smoking.

The study was financed by the Italian Health Ministry.

City life also promotes a sedentary lifestyle and obesity, also negatively impacts sperm count, according to SIAMS.

"It's worth reminding youth because they are completely ignorant about the risk to fertility," SIAMS said.

©2011 Adnkronos International (Rome)

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Fewer Teens Smoking

Posted Dec 17, 2011

Teenage smoking declined for the fourth consecutive year during 2011, according to the annual Monitoring the Future study released Wednesday.

The smoking rate was at 18.7 percent for 12th-graders, the lowest in the 36-year history of the study, which is conducted by University of Michigan researchers. The study measures tobacco usage over a 30-day period.

By comparison, the smoking rate among 12th-graders was 19.2 percent in 2010 and 29.5 in 2001. Nearly 20 percent of adult Americans smoke, according to the Centers for Disease Control and Prevention.

The study included about 47,000 eighth-, 10th- and 12th-graders from about 400 schools.

“This is very good news for the health and longevity of these young people,” said Lloyd Johnston, principal investigator of the study. “Even a reduction of only one percentage point can translate into thousands of premature deaths being prevented.”

Matt Myers, president of the Campaign for Tobacco-Free Kids, said that the overall decline in teen smoking during 2011 was welcome news because the rate of decline had nearly stalled in recent years.

Myers said a further reduction in teen smoking will require elected officials to continue to push for “higher tobacco taxes, well-funded tobacco prevention and cessation programs that include mass media campaigns, strong smoke-free laws and effective regulation of tobacco products and marketing.”

The study also showed marijuana use is becoming more popular among U.S. teenagers, including reaching a 30-year high among 12th -graders at 22.6 percent. Synthetic marijuana, which became illegal in North Carolina on July 1, was added to the marijuana category in 2011.

However, alcohol use reached a historically low level of 40 percent in 2011. The study also found energy drinks are consumed by about 33 percent of teens, with the highest use among eighth- and 10th-graders.

Health and tobacco-industry officials have paid close attention to smokeless tobacco use in the past five years to determine whether overall tobacco use is declining or just shifting to other options.

The study found 8.3 percent of 12th-graders used the products within a 30-day period, down from 8.5 percent in 2010, but still up from a low of 6.1 percent in 2006.

The rate of use among eighth-graders was at 3.5 percent, down from 4.1 percent in 2010, while the use among 10th-graders dropped to 6.6 percent from 7.5 percent in 2010.

Most researchers and analysts said that it is too soon to tell whether the combination of new smokeless-tobacco products, particularly from subsidiaries of Reynolds American Inc., and recent advertising in magazines played a prominent role in the increases.

Among the more outspoken proponents of smokeless-tobacco products as reduced-risk alternatives has been Bill Godshall, executive director of SmokeFree Pennsylvania.

Godshall praised the decrease in teen smoking as “excellent news.” Besides most of the initiatives cited by Myers, Godshall also supports raising the smoking age to 19.

“It appears that more youth smokers, like adult smokers, are beginning to substitute smokeless tobacco for cigarettes,” Godshall said. “Since cigarettes are 100 times more hazardous than smokeless tobacco, public health benefits every time a smoker switches to smokeless, regardless of age.”

Dr. John Spangler, a professor of family and community medicine at Wake Forest University School of Medicine, said he remains concerned by the level of teens using smokeless tobacco products. Spangler is conducting a National Cancer Institute study that’s aimed at developing strategies to encourage reduced use or even quitting smokeless-tobacco products. Wake Forest received a $2.9 million grant for its study.

“What will happen to these smokeless tobacco users is a huge concern because a strong predictor of future smoking is past smokeless tobacco use,” Spangler said.

©2011 Winston-Salem Journal (Winston Salem, N.C.)

Teenage smoking declined for the fourth consecutive year during 2011, according to the annual Monitoring the Future study released Wednesday.

The smoking rate was at 18.7 percent for 12th-graders, the lowest in the 36-year history of the study, which is conducted by University of Michigan researchers. The study measures tobacco usage over a 30-day period.

By comparison, the smoking rate among 12th-graders was 19.2 percent in 2010 and 29.5 in 2001. Nearly 20 percent of adult Americans smoke, according to the Centers for Disease Control and Prevention.

The study included about 47,000 eighth-, 10th- and 12th-graders from about 400 schools.

"This is very good news for the health and longevity of these young people," said Lloyd Johnston, principal investigator of the study. "Even a reduction of only one percentage point can translate into thousands of premature deaths being prevented."

Matt Myers, president of the Campaign for Tobacco-Free Kids, said that the overall decline in teen smoking during 2011 was welcome news because the rate of decline had nearly stalled in recent years.

Myers said a further reduction in teen smoking will require elected officials to continue to push for "higher tobacco taxes, well-funded tobacco prevention and cessation programs that include mass media campaigns, strong smoke-free laws and effective regulation of tobacco products and marketing."

The study also showed marijuana use is becoming more popular among U.S. teenagers, including reaching a 30-year high among 12th -graders at 22.6 percent. Synthetic marijuana, which became illegal in North Carolina on July 1, was added to the marijuana category in 2011.

However, alcohol use reached a historically low level of 40 percent in 2011. The study also found energy drinks are consumed by about 33 percent of teens, with the highest use among eighth- and 10th-graders.

Health and tobacco-industry officials have paid close attention to smokeless tobacco use in the past five years to determine whether overall tobacco use is declining or just shifting to other options.

The study found 8.3 percent of 12th-graders used the products within a 30-day period, down from 8.5 percent in 2010, but still up from a low of 6.1 percent in 2006.

The rate of use among eighth-graders was at 3.5 percent, down from 4.1 percent in 2010, while the use among 10th-graders dropped to 6.6 percent from 7.5 percent in 2010.

Most researchers and analysts said that it is too soon to tell whether the combination of new smokeless-tobacco products, particularly from subsidiaries of Reynolds American Inc., and recent advertising in magazines played a prominent role in the increases.

Among the more outspoken proponents of smokeless-tobacco products as reduced-risk alternatives has been Bill Godshall, executive director of SmokeFree Pennsylvania.

Godshall praised the decrease in teen smoking as "excellent news." Besides most of the initiatives cited by Myers, Godshall also supports raising the smoking age to 19.

"It appears that more youth smokers, like adult smokers, are beginning to substitute smokeless tobacco for cigarettes," Godshall said. "Since cigarettes are 100 times more hazardous than smokeless tobacco, public health benefits every time a smoker switches to smokeless, regardless of age."

Dr. John Spangler, a professor of family and community medicine at Wake Forest University School of Medicine, said he remains concerned by the level of teens using smokeless tobacco products. Spangler is conducting a National Cancer Institute study that's aimed at developing strategies to encourage reduced use or even quitting smokeless-tobacco products. Wake Forest received a $2.9 million grant for its study.

"What will happen to these smokeless tobacco users is a huge concern because a strong predictor of future smoking is past smokeless tobacco use," Spangler said.

©2011 Winston-Salem Journal (Winston Salem, N.C.)

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Depression Linked to Stroke

Posted Dec 8, 2011

DEPRESSION may increase the chances of women having a stroke, research suggests.

A large six-year study found that a history of depression increased the risk of stroke in post-menopausal women by 29%.

Women who used common antidepressants such as Prozac had a 39% higher risk. But scientists said drugs on their own were not thought to be the primary cause of higher stroke risk and they urged women not to stop taking their medication.

Co-author Dr An Pan, from Harvard Public School of Health in Boston, said depression could be linked to inflammation, which in turn might increase the risk of stroke and other conditions.

“Regardless of the mechanism, recognising that depressed individuals may be at a higher risk of stroke may help the physician focus on not only treating the depression, but treating stroke risk factors such as hypertension, diabetes and elevated cholesterol, as well as addressing lifestyle behaviours such as smoking and exercise,” he said.

Dr Peter Coleman, deputy director of research at The Stroke Association, said more research was needed to determine whether depression alone could be a stroke risk factor.

Women suffering from depression may be less motivated to maintain good health or control other medical conditions linked to an increased risk of stroke, he said.

DEPRESSION may increase the chances of women having a stroke, research suggests.

A large six-year study found that a history of depression increased the risk of stroke in post-menopausal women by 29%.

Women who used common antidepressants such as Prozac had a 39% higher risk. But scientists said drugs on their own were not thought to be the primary cause of higher stroke risk and they urged women not to stop taking their medication.

Co-author Dr An Pan, from Harvard Public School of Health in Boston, said depression could be linked to inflammation, which in turn might increase the risk of stroke and other conditions.

"Regardless of the mechanism, recognising that depressed individuals may be at a higher risk of stroke may help the physician focus on not only treating the depression, but treating stroke risk factors such as hypertension, diabetes and elevated cholesterol, as well as addressing lifestyle behaviours such as smoking and exercise," he said.

Dr Peter Coleman, deputy director of research at The Stroke Association, said more research was needed to determine whether depression alone could be a stroke risk factor.

Women suffering from depression may be less motivated to maintain good health or control other medical conditions linked to an increased risk of stroke, he said.

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Low Vitamin D Levels Bad for Back Surgery Patients

Posted Dec 3, 2011

A new study found that more than half of the people undergoing spinal fusion surgery had inadequate levels of vitamin D, a condition that doctors say might reduce their chances of having successful back surgery.

The research involved 313 adults undergoing fusion surgery at Washington University in St. Louis in 2010 and 2011. Their blood levels of vitamin D were tested before surgery.

A total of 57% of the patients had inadequate vitamin D levels, defined as a blood level of less than 30 nanograms per milliliter. Of those, 27% had deficient vitamin D (less than 20 ng/ml) and 4% had a severe deficiency (less than 10 ng/ml).

“It was alarming to see that so many patients have inadequate or deficient vitamin D levels, especially when vitamin D is so readily available and inexpensive,” said lead author Jacob Buchowski, an associate professor of orthopedic and neurological surgery at Washington University. “It’s really the deficient patients we worry about.”

The paper, presented Thursday at the North American Spine Society annual meeting, is the latest in the ongoing controversy about vitamin D and whether people should be supplementing their diets with vitamin D pills.

A substantial amount of observational research has suggested that supplementation may reduce the risk of a variety of diseases, ranging from cancer to heart disease as well as more established bone health benefits.

However, last November the Institute of Medicine concluded that most Americans don’t need to take large amounts of vitamin D or calcium to maintain bone health. It also said there was not sufficient evidence to support other claims about vitamin D supplementation and disease prevention.

For bone health, most people need about 400 International Units a day, though those older than 70 may need as much as 800 IU daily, the institute said.

Proponents say that people living in northern latitudes often make inadequate levels of vitamin D from the sun and that it is difficult to get optimal levels from food.

D is needed to make bone

Doctors say spine surgery patients may represent a special class of people when it comes to vitamin D because successful spinal fusion requires making new bone.

Without vitamin D, “you won’t make bone or the bone you make will be inadequate,” said Christopher Kauffman, an orthopedic surgeon at the University Medical Center in Lebanon, Tenn.

Kauffman noted that vitamin D levels are simple to check and inexpensive to fix.

“It seems like common sense, but it’s not something we’re addressing,” he said.

What the study does not show is whether people who are low in vitamin D will improve their fusion rate if they take supplements before surgery.

It also does not show whether maintaining adequate vitamin D levels throughout life will reduce the incidence of spine degeneration, said Dennis Maiman, chairman of neurosurgery at Froedtert Hospital and the Medical College of Wisconsin.

Maiman said he does not think all back surgery patients need to have their vitamin D levels checked, but it probably is a good idea to check those who are at risk for having low levels. That would include people older than 55 and those with a history of smoking, obesity and diabetes, he said.

Buchowski said the idea of checking vitamin D levels of patients first occurred to him in 2008. A woman in her 40s who had undergone cervical fusion surgery and did not get an adequate fusion told him that she had been treated for a vitamin D deficiency.

“It was like a light bulb went off,” he said.

For the last year and a half, all patients undergoing fusion surgery at Washington University have their vitamin D levels checked.

If they are deficient, they will be supplemented with a 50,000 IU prescription dose once a week for eight weeks before their surgery, he said.

“That usually gets them into the normal range,” he said. “Having a spine fusion is a big deal. I want to do everything I can to improve outcomes.”

The researchers said that while older adults are more likely to have low vitamin D levels, younger adults undergoing spine surgery should not be overlooked.

©2011 the Milwaukee Journal Sentinel

A new study found that more than half of the people undergoing spinal fusion surgery had inadequate levels of vitamin D, a condition that doctors say might reduce their chances of having successful back surgery.

The research involved 313 adults undergoing fusion surgery at Washington University in St. Louis in 2010 and 2011. Their blood levels of vitamin D were tested before surgery.

A total of 57% of the patients had inadequate vitamin D levels, defined as a blood level of less than 30 nanograms per milliliter. Of those, 27% had deficient vitamin D (less than 20 ng/ml) and 4% had a severe deficiency (less than 10 ng/ml).

"It was alarming to see that so many patients have inadequate or deficient vitamin D levels, especially when vitamin D is so readily available and inexpensive," said lead author Jacob Buchowski, an associate professor of orthopedic and neurological surgery at Washington University. "It's really the deficient patients we worry about."

The paper, presented Thursday at the North American Spine Society annual meeting, is the latest in the ongoing controversy about vitamin D and whether people should be supplementing their diets with vitamin D pills.

A substantial amount of observational research has suggested that supplementation may reduce the risk of a variety of diseases, ranging from cancer to heart disease as well as more established bone health benefits.

However, last November the Institute of Medicine concluded that most Americans don't need to take large amounts of vitamin D or calcium to maintain bone health. It also said there was not sufficient evidence to support other claims about vitamin D supplementation and disease prevention.

For bone health, most people need about 400 International Units a day, though those older than 70 may need as much as 800 IU daily, the institute said.

Proponents say that people living in northern latitudes often make inadequate levels of vitamin D from the sun and that it is difficult to get optimal levels from food.

D is needed to make bone

Doctors say spine surgery patients may represent a special class of people when it comes to vitamin D because successful spinal fusion requires making new bone.

Without vitamin D, "you won't make bone or the bone you make will be inadequate," said Christopher Kauffman, an orthopedic surgeon at the University Medical Center in Lebanon, Tenn.

Kauffman noted that vitamin D levels are simple to check and inexpensive to fix.

"It seems like common sense, but it's not something we're addressing," he said.

What the study does not show is whether people who are low in vitamin D will improve their fusion rate if they take supplements before surgery.

It also does not show whether maintaining adequate vitamin D levels throughout life will reduce the incidence of spine degeneration, said Dennis Maiman, chairman of neurosurgery at Froedtert Hospital and the Medical College of Wisconsin.

Maiman said he does not think all back surgery patients need to have their vitamin D levels checked, but it probably is a good idea to check those who are at risk for having low levels. That would include people older than 55 and those with a history of smoking, obesity and diabetes, he said.

Buchowski said the idea of checking vitamin D levels of patients first occurred to him in 2008. A woman in her 40s who had undergone cervical fusion surgery and did not get an adequate fusion told him that she had been treated for a vitamin D deficiency.

"It was like a light bulb went off," he said.

For the last year and a half, all patients undergoing fusion surgery at Washington University have their vitamin D levels checked.

If they are deficient, they will be supplemented with a 50,000 IU prescription dose once a week for eight weeks before their surgery, he said.

"That usually gets them into the normal range," he said. "Having a spine fusion is a big deal. I want to do everything I can to improve outcomes."

The researchers said that while older adults are more likely to have low vitamin D levels, younger adults undergoing spine surgery should not be overlooked.

©2011 the Milwaukee Journal Sentinel

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Blame Potato Chips for Weight Gain

Posted Dec 2, 2011

Blame the potato chip. It’s the biggest demon behind that pound-a-year weight creep that plagues many of us, a major diet study found. Bigger than soda, candy and ice cream.

And the reason is partly that old advertising cliche: You can’t eat just one.

“They’re very tasty and they have a very good texture. People generally don’t take one or two chips. They have a whole bag,” said obesity expert Dr. F. Xavier Pi-Sunyer of the St. Luke’s-Roosevelt Hospital Center in New York.

What we eat and how much of it we consume has far more impact than exercise and most other habits do on long-term weight gain, according to the study by Harvard University scientists. It’s the most comprehensive look yet at the effect of individual foods and lifestyle choices like sleep time and quitting smoking.

The results are in Thursday’s New England Journal of Medicine.

Weight problems are epidemic. Two-thirds of American adults are overweight or obese. Childhood obesity has tripled in the past three decades. Pounds often are packed on gradually over decades, and many people struggle to limit weight gain without realizing what’s causing it.

The new study finds food choices are key. The message: Eat more fruits, vegetables, whole grains and nuts. Cut back on potatoes, red meat, sweets and soda.

“There is no magic bullet for weight control,” said one study leader, Dr. Frank Hu. “Diet and exercise are important for preventing weight gain, but diet clearly plays a bigger role.”

Doctors analyzed changes in diet and lifestyle habits of 120,877 people from three long-running medical studies. All were health professionals and not obese at the start. Their weight was measured every four years for up to two decades, and they detailed their diet on questionnaires.

On average, participants gained nearly 17 pounds over the 20-year period.

For each four-year period, food choices contributed nearly 4 pounds. Exercise, for those who did it, cut less than 2 pounds.

Potato chips were the biggest dietary offender. Each daily serving containing 1 ounce (about 15 chips and 160 calories) led to a 1.69-pound uptick over four years. That’s compared to sweets and desserts, which added 0.41 pound.

For starchy potatoes other than chips, the gain was 1.28 pounds. Within the spud group, french fries were worse for the waist than boiled, baked or mashed potatoes. That’s because a serving of large fries contains between 500 to 600 calories compared with a serving of a large baked potato at 280 calories.

Soda added a pound over four years. Eating more fruits and vegetables and other unprocessed foods led to less weight gain, probably because they are fiber-rich and make people feel fuller.

For each four-year period, these factors had these effects on weight:

- An alcoholic drink a day, 0.41-pound increase.

- Watching an hour of TV a day, 0.31-pound increase.

- Recently quitting smoking, 5-pound increase.

People who slept more or less than six to eight hours a night gained more weight.

The study was funded by the National Institutes of Health and a foundation. Several researchers reported receiving fees from drug and nutrition companies.

“Humans naturally like fat and sweet,” said Dr. David Heber, director of the UCLA Center for Human Nutrition, who had no role in the study. “That’s why we always tell people to eat their fruits and vegetables.”

Pi-Sunyer, who also wasn’t involved in the research, said the study gives useful advice.

“It’s hard to lose weight once you gain it,” he said. “Anything that will give people a clue about what might prevent weight gain if they follow through with it is helpful.”

The federal government earlier this year issued new dietary guidelines advising people to eat smarter. This month, it ditched the food pyramid – the longtime symbol of healthy eating – in favor of a dinner plate divided into four sections containing fruits, vegetables, protein and grains.

Online:

New England Journal of Medicine: http://www.nejm.org

Blame the potato chip. It's the biggest demon behind that pound-a-year weight creep that plagues many of us, a major diet study found. Bigger than soda, candy and ice cream.

And the reason is partly that old advertising cliche: You can't eat just one.

"They're very tasty and they have a very good texture. People generally don't take one or two chips. They have a whole bag," said obesity expert Dr. F. Xavier Pi-Sunyer of the St. Luke's-Roosevelt Hospital Center in New York.

What we eat and how much of it we consume has far more impact than exercise and most other habits do on long-term weight gain, according to the study by Harvard University scientists. It's the most comprehensive look yet at the effect of individual foods and lifestyle choices like sleep time and quitting smoking.

The results are in Thursday's New England Journal of Medicine.

Weight problems are epidemic. Two-thirds of American adults are overweight or obese. Childhood obesity has tripled in the past three decades. Pounds often are packed on gradually over decades, and many people struggle to limit weight gain without realizing what's causing it.

The new study finds food choices are key. The message: Eat more fruits, vegetables, whole grains and nuts. Cut back on potatoes, red meat, sweets and soda.

"There is no magic bullet for weight control," said one study leader, Dr. Frank Hu. "Diet and exercise are important for preventing weight gain, but diet clearly plays a bigger role."

Doctors analyzed changes in diet and lifestyle habits of 120,877 people from three long-running medical studies. All were health professionals and not obese at the start. Their weight was measured every four years for up to two decades, and they detailed their diet on questionnaires.

On average, participants gained nearly 17 pounds over the 20-year period.

For each four-year period, food choices contributed nearly 4 pounds. Exercise, for those who did it, cut less than 2 pounds.

Potato chips were the biggest dietary offender. Each daily serving containing 1 ounce (about 15 chips and 160 calories) led to a 1.69-pound uptick over four years. That's compared to sweets and desserts, which added 0.41 pound.

For starchy potatoes other than chips, the gain was 1.28 pounds. Within the spud group, french fries were worse for the waist than boiled, baked or mashed potatoes. That's because a serving of large fries contains between 500 to 600 calories compared with a serving of a large baked potato at 280 calories.

Soda added a pound over four years. Eating more fruits and vegetables and other unprocessed foods led to less weight gain, probably because they are fiber-rich and make people feel fuller.

For each four-year period, these factors had these effects on weight:

- An alcoholic drink a day, 0.41-pound increase.

- Watching an hour of TV a day, 0.31-pound increase.

- Recently quitting smoking, 5-pound increase.

People who slept more or less than six to eight hours a night gained more weight.

The study was funded by the National Institutes of Health and a foundation. Several researchers reported receiving fees from drug and nutrition companies.

"Humans naturally like fat and sweet," said Dr. David Heber, director of the UCLA Center for Human Nutrition, who had no role in the study. "That's why we always tell people to eat their fruits and vegetables."

Pi-Sunyer, who also wasn't involved in the research, said the study gives useful advice.

"It's hard to lose weight once you gain it," he said. "Anything that will give people a clue about what might prevent weight gain if they follow through with it is helpful."

The federal government earlier this year issued new dietary guidelines advising people to eat smarter. This month, it ditched the food pyramid - the longtime symbol of healthy eating - in favor of a dinner plate divided into four sections containing fruits, vegetables, protein and grains.

Online:

New England Journal of Medicine: http://www.nejm.org

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Smokers More Likely to Quit with Monthly Calls

Posted Dec 1, 2011

You won’t find the word “nagging” in the study.

But scientists at the University of Minnesota have found that smokers are more likely to kick the habit if a counselor calls them every month for a year with helpful tips and nicotine patches.

Typically, stop-smoking programs only last about eight weeks. But Dr. Anne Joseph, a professor of medicine, and her colleagues found that they could boost the success rate as much as 75 percent by extending treatment to 12 months.

As part of the program, counselors stayed in touch with patients for a full year, calling some patients as many as 50 times. The counselors adopted what they called a “chronic disease” model of care, which meant they didn’t give up if the smoker relapsed.

They encouraged smokers to keep trying and gave them the option of cutting back on tobacco use if they were unwilling to give it up completely — at least as a first step.

“You could call it nagging,” said Joseph, “but we prefer to call it … persistent. We were very persistent.”

In the end, 30.2 percent of the experimental group gave up smoking for six months or more — the benchmark of success — compared to 23.5 percent in the conventional program.

It’s common knowledge that stop-smoking programs have high failure rates.

“Unfortunately, most smokers relapse within three months of treatment,” Joseph and her colleagues noted in the study, which was published Monday in the Archives of Internal Medicine.

In this case, Joseph said, they tried to mimic the treatment plans for chronic conditions such as diabetes or high blood pressure. That means working with patients over time, adjusting their medications and offering encouragement to keep trying.

“We would ramp up the phone calls to do what we call relapse-sensitive calling,” Joseph said, especially for the first week of abstinence, when smokers are most vulnerable to relapse.

“Some people got really lots and lots of calls.”

Of course, the counselors tried to be more sensitive than, say, a nagging parent. “It was intentionally non-judgmental,” Joseph said. “And that’s probably the big difference between a mom and a counselor.”

On average, the more intense program cost $944 per person, about twice the cost of the eight-week program. But when the researchers adjusted for differences in the two study groups, they found the experimental program was 75 percent more effective at getting smokers to quit long-term.

“I think the take-home message,” Joseph said, “is that if a person wants to quit smoking … they just have to keep going at it and tweaking their treatment until they achieve that goal.”

Maura Lerner –612-673-7384

___

©2011 the Star Tribune (Minneapolis)

You won't find the word "nagging" in the study.

But scientists at the University of Minnesota have found that smokers are more likely to kick the habit if a counselor calls them every month for a year with helpful tips and nicotine patches.

Typically, stop-smoking programs only last about eight weeks. But Dr. Anne Joseph, a professor of medicine, and her colleagues found that they could boost the success rate as much as 75 percent by extending treatment to 12 months.

As part of the program, counselors stayed in touch with patients for a full year, calling some patients as many as 50 times. The counselors adopted what they called a "chronic disease" model of care, which meant they didn't give up if the smoker relapsed.

They encouraged smokers to keep trying and gave them the option of cutting back on tobacco use if they were unwilling to give it up completely -- at least as a first step.

"You could call it nagging," said Joseph, "but we prefer to call it ... persistent. We were very persistent."

In the end, 30.2 percent of the experimental group gave up smoking for six months or more -- the benchmark of success -- compared to 23.5 percent in the conventional program.

It's common knowledge that stop-smoking programs have high failure rates.

"Unfortunately, most smokers relapse within three months of treatment," Joseph and her colleagues noted in the study, which was published Monday in the Archives of Internal Medicine.

In this case, Joseph said, they tried to mimic the treatment plans for chronic conditions such as diabetes or high blood pressure. That means working with patients over time, adjusting their medications and offering encouragement to keep trying.

"We would ramp up the phone calls to do what we call relapse-sensitive calling," Joseph said, especially for the first week of abstinence, when smokers are most vulnerable to relapse.

"Some people got really lots and lots of calls."

Of course, the counselors tried to be more sensitive than, say, a nagging parent. "It was intentionally non-judgmental," Joseph said. "And that's probably the big difference between a mom and a counselor."

On average, the more intense program cost $944 per person, about twice the cost of the eight-week program. But when the researchers adjusted for differences in the two study groups, they found the experimental program was 75 percent more effective at getting smokers to quit long-term.

"I think the take-home message," Joseph said, "is that if a person wants to quit smoking ... they just have to keep going at it and tweaking their treatment until they achieve that goal."

Maura Lerner --612-673-7384

___

©2011 the Star Tribune (Minneapolis)

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Avoiding Alzheimer’s Disease

Posted Nov 19, 2011

Virginia Stone is worried: Alzheimer’s disease seems to run in her family. Her 80-year-old mother, Kazue Storey, was diagnosed seven years ago, and Storey’s mother died of the disease in the 1970s.

So Stone, 53, watches her diet, and she works out at Zumba class several times a week. She’s cut out almost all caffeine, except for one Diet Pepsi every week. She works puzzles like Sudoku and crosswords.

“If you take care of all these things, you can put off dementia longer,” said Stone, marketing director for Carmichael Oaks Senior Living.

Her approach certainly sounds like common sense. In fact, many Alzheimer’s specialists tell their patients that what is good for the heart — a healthy weight, daily exercise, no smoking, lots of fruits and vegetables, a network of social connections — is also good for the brain.

But is that true? Will a healthy lifestyle help prevent Alzheimer’s disease, or at least delay its onset?

As the number of Alzheimer’s cases in the United States continues to climb, such questions have taken on an urgent feel. The Alzheimer’s diagnosis is now shared by 5.4 million Americans, and that number is expected to rise to 16 million by mid-century.

The Alzheimer’s Association calls the illness “the defining disease of baby boomers” — many of whom, like Stone, are already dealing with it in their parents’ lives.

For them, it’s crucial to know whether lifestyle changes will make a difference. But the answer, like so much related to Alzheimer’s, is hard to pin down definitively.

“Alzheimer’s is a complicated condition,” said Bill Fisher, Alzheimer’s Association of Northern California chief executive officer. “The answers are also going to be complex.”

Strictly speaking, experts say, the only known risk factor for Alzheimer’s is old age. Marked by the death of brain tissue and the resulting erosion of memory and ability to function, the disease is already the nation’s sixth-leading cause of death and thought to be responsible for 80 percent of dementia cases.

There is no cure, although one medication, Aricept, has been found to delay symptoms in some patients for a year or two.

Unfortunately, as Fisher points out, research on Alzheimer’s — unlike research on other major killers, such as cancer and heart disease — remains in its infancy.

In large part, that’s because for most of the 20th century, doctors thought Alzheimer’s only caused those rare cases of dementia occurring before age 65, while they diagnosed dementia in the elderly as a different disease, one that was thought to be a normal, if not inevitable, part of growing old.

Once researchers concluded in the 1980s that the pathologies of early and old age dementias were the same, the science could make progress.

Study suggests risk factors

Today, scientists know that Alzheimer’s begins its steady march of killing brain cells 10 years or longer before forgetfulness, confusion and other early symptoms appear. By the time memory problems start, the disease is already consuming the brain.

Prevention, or even simply finding ways to keep symptoms at bay for another decade into old age, would be a major breakthrough for older adults concerned that dementia might be in their future.

And there are tantalizing hints that lifestyle changes really might help.

A new UC San Francisco study — using a sophisticated mathematical model to analyze many years’ worth of observational data about the influence of lifestyle on Alzheimer’s — suggests that about half the world’s known cases of the disease could be attributable to seven modifiable risk factors.

Lack of exercise could cause 21 percent of Alzheimer’s in America, and high blood pressure could cause 8 percent, the study theorizes, while low educational attainment and midlife obesity might each cause 7 percent. Diabetes could account for 3 percent.

“The message is, we can’t promise you that if you change your lifestyle you won’t develop dementia, but based on the data we have available now, we think it might make a difference,” said Deborah Barnes, the San Francisco Veterans Affairs Medical Center mental health researcher who co-authored the study.

“And for society, it could make a difference in the number of cases that develop over time.”

Or maybe not.

As an independent panel appointed by the National Institutes of Health to assess a broad range of research on the disease found last year, the problem with connecting lifestyle risks and Alzheimer’s is this: Many studies find correlation, but none definitively proves cause.

Why? Because none has involved the analytical rigor of randomized, controlled trials, the gold standard of modern science.

“Our response to that is, you can’t,” said Charles DeCarli, director of the UC Davis Alzheimer’s Disease Center. “You can’t tell half your group, ‘Don’t treat your diabetes.’ You can’t tell half your group, ‘Don’t treat your hypertension.’

“NIH was correct that there are no controlled studies showing the benefit of lifestyle changes. But they missed the spirit of the science.”

Scans find brain changes

DeCarli’s own new research, published in this month’s Neurology medical journal, followed people in midlife who had diabetes or weight problems or were smokers.

Brain scans taken at 50, then again at 60, found significant changes in most participants’ brain structure — notably including the structure of the hippocampus, the brain’s memory center, one of the first regions that Alzheimer’s disease damages.

Again, it’s a clue that people’s behaviors earlier in life could put them at increased risk of dementia as they grow older.

“We have accumulating evidence saying that lifestyle modifications may help,” said Dr. Laurie Ryan, program director for Alzheimer’s disease clinical trials at the National Institute on Aging.

Among those trials are research on whether exercise, cognitive training and certain supplements, such as fish oil, can help stave off Alzheimer’s.

“There’s accumulating data that diet and being physically active and staying socially engaged promote healthy brain aging,” she said. “But we can’t prescribe those yet.

“Can we say, ‘Do these things, and you won’t get Alzheimer’s?’ No. But this is something people can take control of. They’ll age better. It will help, but it’s not a guarantee.”

Researchers know that many people live energetic, involved lives and eat right but still get dementia. But for many other people, said Ryan, it’s possible that healthy habits will help keep their brain pathways nimble enough that they never exhibit cognitive decline, even if they have other evidence of Alzheimer’s pathology.

For example, researchers think higher levels of education protect against Alzheimer’s, because the brain fairly early in life learns to make new neural pathways, improving thinking and memory abilities — what experts call “cognitive reserve.”

Besides, said Fisher: “Lifestyle changes are something you can do that doesn’t require a pharmaceutical company to develop something that doesn’t exist yet.”

In other words, exercising, eating better, doing crossword puzzles and playing bridge with old friends can’t hurt. And they just might help.

Hope is all Virginia Stone wants.

Her mother, who lives in Palo Alto, began showing signs of memory loss almost a decade ago, Stone says. And the slow, sad progression began.

Stone changed career fields — from retail sales to senior living — because she wanted to understand Alzheimer’s and learn how to better support her father, Jack Storey, 86, who takes care of Kazue.

“Even if you’re not worried about Alzheimer’s, taking care of your body is good for you,” she said.

“If I can put off Alzheimer’s for a few years, that’s good. And if I can put off the inevitable long enough, maybe I’ll never get it.”

Call The Bee’s Anita Creamer, (916) 321-1136.

Copyright © 2011, The Sacramento Bee, Calif.

Virginia Stone is worried: Alzheimer's disease seems to run in her family. Her 80-year-old mother, Kazue Storey, was diagnosed seven years ago, and Storey's mother died of the disease in the 1970s.

So Stone, 53, watches her diet, and she works out at Zumba class several times a week. She's cut out almost all caffeine, except for one Diet Pepsi every week. She works puzzles like Sudoku and crosswords.

"If you take care of all these things, you can put off dementia longer," said Stone, marketing director for Carmichael Oaks Senior Living.

Her approach certainly sounds like common sense. In fact, many Alzheimer's specialists tell their patients that what is good for the heart -- a healthy weight, daily exercise, no smoking, lots of fruits and vegetables, a network of social connections -- is also good for the brain.

But is that true? Will a healthy lifestyle help prevent Alzheimer's disease, or at least delay its onset?

As the number of Alzheimer's cases in the United States continues to climb, such questions have taken on an urgent feel. The Alzheimer's diagnosis is now shared by 5.4 million Americans, and that number is expected to rise to 16 million by mid-century.

The Alzheimer's Association calls the illness "the defining disease of baby boomers" -- many of whom, like Stone, are already dealing with it in their parents' lives.

For them, it's crucial to know whether lifestyle changes will make a difference. But the answer, like so much related to Alzheimer's, is hard to pin down definitively.

"Alzheimer's is a complicated condition," said Bill Fisher, Alzheimer's Association of Northern California chief executive officer. "The answers are also going to be complex."

Strictly speaking, experts say, the only known risk factor for Alzheimer's is old age. Marked by the death of brain tissue and the resulting erosion of memory and ability to function, the disease is already the nation's sixth-leading cause of death and thought to be responsible for 80 percent of dementia cases.

There is no cure, although one medication, Aricept, has been found to delay symptoms in some patients for a year or two.

Unfortunately, as Fisher points out, research on Alzheimer's -- unlike research on other major killers, such as cancer and heart disease -- remains in its infancy.

In large part, that's because for most of the 20th century, doctors thought Alzheimer's only caused those rare cases of dementia occurring before age 65, while they diagnosed dementia in the elderly as a different disease, one that was thought to be a normal, if not inevitable, part of growing old.

Once researchers concluded in the 1980s that the pathologies of early and old age dementias were the same, the science could make progress.

Study suggests risk factors

Today, scientists know that Alzheimer's begins its steady march of killing brain cells 10 years or longer before forgetfulness, confusion and other early symptoms appear. By the time memory problems start, the disease is already consuming the brain.

Prevention, or even simply finding ways to keep symptoms at bay for another decade into old age, would be a major breakthrough for older adults concerned that dementia might be in their future.

And there are tantalizing hints that lifestyle changes really might help.

A new UC San Francisco study -- using a sophisticated mathematical model to analyze many years' worth of observational data about the influence of lifestyle on Alzheimer's -- suggests that about half the world's known cases of the disease could be attributable to seven modifiable risk factors.

Lack of exercise could cause 21 percent of Alzheimer's in America, and high blood pressure could cause 8 percent, the study theorizes, while low educational attainment and midlife obesity might each cause 7 percent. Diabetes could account for 3 percent.

"The message is, we can't promise you that if you change your lifestyle you won't develop dementia, but based on the data we have available now, we think it might make a difference," said Deborah Barnes, the San Francisco Veterans Affairs Medical Center mental health researcher who co-authored the study.

"And for society, it could make a difference in the number of cases that develop over time."

Or maybe not.

As an independent panel appointed by the National Institutes of Health to assess a broad range of research on the disease found last year, the problem with connecting lifestyle risks and Alzheimer's is this: Many studies find correlation, but none definitively proves cause.

Why? Because none has involved the analytical rigor of randomized, controlled trials, the gold standard of modern science.

"Our response to that is, you can't," said Charles DeCarli, director of the UC Davis Alzheimer's Disease Center. "You can't tell half your group, 'Don't treat your diabetes.' You can't tell half your group, 'Don't treat your hypertension.'

"NIH was correct that there are no controlled studies showing the benefit of lifestyle changes. But they missed the spirit of the science."

Scans find brain changes

DeCarli's own new research, published in this month's Neurology medical journal, followed people in midlife who had diabetes or weight problems or were smokers.

Brain scans taken at 50, then again at 60, found significant changes in most participants' brain structure -- notably including the structure of the hippocampus, the brain's memory center, one of the first regions that Alzheimer's disease damages.

Again, it's a clue that people's behaviors earlier in life could put them at increased risk of dementia as they grow older.

"We have accumulating evidence saying that lifestyle modifications may help," said Dr. Laurie Ryan, program director for Alzheimer's disease clinical trials at the National Institute on Aging.

Among those trials are research on whether exercise, cognitive training and certain supplements, such as fish oil, can help stave off Alzheimer's.

"There's accumulating data that diet and being physically active and staying socially engaged promote healthy brain aging," she said. "But we can't prescribe those yet.

"Can we say, 'Do these things, and you won't get Alzheimer's?' No. But this is something people can take control of. They'll age better. It will help, but it's not a guarantee."

Researchers know that many people live energetic, involved lives and eat right but still get dementia. But for many other people, said Ryan, it's possible that healthy habits will help keep their brain pathways nimble enough that they never exhibit cognitive decline, even if they have other evidence of Alzheimer's pathology.

For example, researchers think higher levels of education protect against Alzheimer's, because the brain fairly early in life learns to make new neural pathways, improving thinking and memory abilities -- what experts call "cognitive reserve."

Besides, said Fisher: "Lifestyle changes are something you can do that doesn't require a pharmaceutical company to develop something that doesn't exist yet."

In other words, exercising, eating better, doing crossword puzzles and playing bridge with old friends can't hurt. And they just might help.

Hope is all Virginia Stone wants.

Her mother, who lives in Palo Alto, began showing signs of memory loss almost a decade ago, Stone says. And the slow, sad progression began.

Stone changed career fields -- from retail sales to senior living -- because she wanted to understand Alzheimer's and learn how to better support her father, Jack Storey, 86, who takes care of Kazue.

"Even if you're not worried about Alzheimer's, taking care of your body is good for you," she said.

"If I can put off Alzheimer's for a few years, that's good. And if I can put off the inevitable long enough, maybe I'll never get it."

Call The Bee's Anita Creamer, (916) 321-1136.

Copyright © 2011, The Sacramento Bee, Calif.

Tags: , , , , , , , , , , , ,



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Disease Risk Determined Before You Are Born

Posted Nov 18, 2011

Pregnant women sacrifice many of life’s simple pleasures — caffeine, sushi, a glass of wine — in the hope that their baby will be born healthy.

But according to a provocative new field of research, what happens during pregnancy can have lasting consequences that emerge decades after the child leaves the hospital. Studies are finding that adult illnesses like heart disease, stroke, cancer and diabetes can have roots in the mysterious months we spend in the womb.

Although genetics and lifestyle choices certainly influence an adult’s risk of getting a disease, researchers now believe that the food a pregnant woman eats, her weight and fitness, her stress level, and the drugs, pollutants and infections she is exposed to can trigger changes that also make her baby vulnerable to disease after birth.

For example, scientists have found that a diet containing excessive protein can suppress fetal growth and lead to adult-onset hypertension. Expectant mothers who starved during their final trimester as a result of the Dutch famine of 1944-45 were more likely to have babies who later developed Type 2 diabetes. And the children of obese mothers also are at high risk of Type 2 diabetes and metabolic syndrome.

“Human beings break down the same reason cars break down; they’re either driven on bad roads or made badly in the first place,” said David Barker, a professor of clinical epidemiology at England’s University of Southampton, who in 1989 initially advanced the idea that coronary heart disease might originate in fetal life. “Some people are just strong and some are not. Being made bad means, biologically, that you have fewer functioning units.”

Experts stress that this field of study is relatively new and that the physical mechanisms that might explain the correlations between stressors in the womb and mechanical problems down the road are unclear.

It is also not lost on researchers that some pregnant women already are wracked with guilt over forgetting their prenatal vitamins or eating hot dogs instead of broccoli.

“I feel like a walking bomb,” said Chicago’s Amy Elstein, 28, who is five months pregnant and fears that her stress levels are affecting her baby. “It’s like my body is not my own. Everything I put into it — what I eat, what I breathe — I worry that will have an effect on my child.”

“Pregnancy feels like a period in your life when you want very badly to do the right thing, but you don’t have control of what’s going to happen, so women look for areas they can control,” said Dr. Ann Borders, an assistant professor of obstetrics and gynecology at Northwestern University. “We’re trying to help women be aware of unhealthy stresses but not freak out that they’re hurting baby for long term.”

The current advice for pregnant women still stands: Eat nutritious foods, exercise, reduce stress and avoid smoking and drinking.

But Barker and other scientists in the field want to step up prenatal care radically because they believe the diets of girls and young women are determining the health of the next generation.

Eventually, this area of research “will make a huge impact on not just what we tell women during pregnancy, but what our children’s health will be,” said Alan Guttmacher, director of the National Institute of Child Health and Human Development.

It was once widely assumed that, aside from cigarette smoke, drugs and excessive alcohol, the uterus, or womb, sheltered the fetus from environmental influences. Scientists also thought that the growing fetus could siphon off necessary nutrients from a mother like a parasite to ensure its survival.

Two decades of research into the fetal origins of disease, however, have challenged both assumptions and led to a revolutionary shift into the thinking about health and development.

According to Barker’s widely accepted fetal origins theory, also referred to as the developmental origins of health and disease, stressors in the womb can permanently change a fetus’s body structure, physiology and metabolism. Those changes then can lead to a higher risk of illness in the future.

Though some research looks at the effects of environmental exposures and psychological stress, much attention centers on nutrient deprivation, which occurs when the mother isn’t getting amino acids, glucose and lipids to the developing baby quickly enough to meet its growing needs.

For example, most pancreatic beta cells — they produce the insulin that regulates blood sugar — are produced during fetal life, said Dr. Susan Ozanne, a British Heart Foundation senior fellow at the University of Cambridge. If the environment in the womb is suboptimal, as when a mother isn’t getting enough protein to the fetus, the baby can wind up with fewer beta cells.

“This causes us problems later on, particularly if we place high demands on our body to produce insulin by becoming obese or eating high-sugar diets. Then we don’t have enough beta cells to produce the amount of insulin we need,” Ozanne said.

Nourishing a fetus, however, involves more than just eating the right foods. A woman’s body composition also can affect how well her placenta transfers nutrients to the fetus.

“Different types of women provide different levels of access to her nutrients,” said Kent Thornburg, director of the Heart Research Center at Oregon Health and Science University. “Thin mothers with low amounts of muscle are less able to handle protein than more muscular women, for example. Women who carry large amounts of fat are in a constant state of mild inflammation, which affects the formation and function of the placenta.”

Fetal programming may work in at least two ways. One is that nutrient deprivation may simply stunt the growth of organs or tissue.

If a fetus can’t get enough nutrients, scientists believe, it adapts by diverting sustenance to organs crucial for survival, such as the brain and heart. That can compromise other organs, such as the kidneys, lungs and pancreas, leaving the developing baby more vulnerable to illness down the road.

“The idea of the human baby as an efficient extraction of nutrients from mother is completely wrong,” said Barker, also a professor of medicine at Oregon Health and Science University. Muscle growth also can be sacrificed, as an undernourished fetus will try to maintain levels of blood glucose by making its muscles resistant to the effects of insulin. This thrifty handling of sugar turns into a liability after birth, when sugar from freely available food floods the blood and obesity can make the body even more resistant to insulin, which leads to diabetes.

The other proposed mechanism is epigenetics, a process by which stressors modify the body’s DNA in ways that affect the functioning of key genes.

Ozanne and her colleagues at Cambridge found that rat pups whose mothers ate a low-protein diet during pregnancy had low levels of activity of a gene called HNF4. That “leads to a reduction in the number of pancreatic beta cells that develop in the fetus, making them less able to produce sufficient levels of insulin in adulthood,” Ozanne said.

Fetal exposure to the stress hormone cortisol appears to trigger both processes.

The placenta normally shields a fetus from exposure to cortisol, but if a mother is chronically stressed — constantly in fight-or-flight mode — it can’t produce enough enzymes to do the job. If the fetus is exposed, Thornburg said, cortisol not only slows growth in most organs, “it also modifies genes through epigenetic mechanisms to make them lose their protective functions.”

Chicago’s Sara Strother, 30, who is due in December, said she keeps her stress levels down with yoga and avoids pesticides, plastic containers, cigarette smoke, alcohol, chemicals found in commercial cleaning products, airplanes (because of radiation exposure), even people with negative attitudes.

“You name it, I am paranoid,” Strother said during a recent Mother Me childbirth education class at Sweet Pea’s Studio in Chicago.

Early in Strother’s pregnancy, she bought a juicer and binged on carrot juice. She then panicked after reading that high doses of vitamin A could be harmful. Her midwife eased her concerns: Carrots are OK. High doses of vitamin A supplements may not be.

Elstein, a recruiter, said she also tries to be careful about what she eats, drinks and inhales. She holds her breath around buses and moved out of the house for two days when a room was painted. “I’m so scared something will go wrong and I will blame myself, so I cope by trying to control what I can to ease my concerns.”

Eventually, she talked to a therapist who reminded her that many people have babies in less than ideal circumstances and things work out.

“That’s what I try to remind myself when I get nervous or scared,” she said. “The cells are dividing and there’s nothing I can do to stop this train from leaving the station.”

jdeardorff@tribune.com

Twitter @Juliedeardorff

©2011 the Chicago Tribune

Pregnant women sacrifice many of life's simple pleasures -- caffeine, sushi, a glass of wine -- in the hope that their baby will be born healthy.

But according to a provocative new field of research, what happens during pregnancy can have lasting consequences that emerge decades after the child leaves the hospital. Studies are finding that adult illnesses like heart disease, stroke, cancer and diabetes can have roots in the mysterious months we spend in the womb.

Although genetics and lifestyle choices certainly influence an adult's risk of getting a disease, researchers now believe that the food a pregnant woman eats, her weight and fitness, her stress level, and the drugs, pollutants and infections she is exposed to can trigger changes that also make her baby vulnerable to disease after birth.

For example, scientists have found that a diet containing excessive protein can suppress fetal growth and lead to adult-onset hypertension. Expectant mothers who starved during their final trimester as a result of the Dutch famine of 1944-45 were more likely to have babies who later developed Type 2 diabetes. And the children of obese mothers also are at high risk of Type 2 diabetes and metabolic syndrome.

"Human beings break down the same reason cars break down; they're either driven on bad roads or made badly in the first place," said David Barker, a professor of clinical epidemiology at England's University of Southampton, who in 1989 initially advanced the idea that coronary heart disease might originate in fetal life. "Some people are just strong and some are not. Being made bad means, biologically, that you have fewer functioning units."

Experts stress that this field of study is relatively new and that the physical mechanisms that might explain the correlations between stressors in the womb and mechanical problems down the road are unclear.

It is also not lost on researchers that some pregnant women already are wracked with guilt over forgetting their prenatal vitamins or eating hot dogs instead of broccoli.

"I feel like a walking bomb," said Chicago's Amy Elstein, 28, who is five months pregnant and fears that her stress levels are affecting her baby. "It's like my body is not my own. Everything I put into it -- what I eat, what I breathe -- I worry that will have an effect on my child."

"Pregnancy feels like a period in your life when you want very badly to do the right thing, but you don't have control of what's going to happen, so women look for areas they can control," said Dr. Ann Borders, an assistant professor of obstetrics and gynecology at Northwestern University. "We're trying to help women be aware of unhealthy stresses but not freak out that they're hurting baby for long term."

The current advice for pregnant women still stands: Eat nutritious foods, exercise, reduce stress and avoid smoking and drinking.

But Barker and other scientists in the field want to step up prenatal care radically because they believe the diets of girls and young women are determining the health of the next generation.

Eventually, this area of research "will make a huge impact on not just what we tell women during pregnancy, but what our children's health will be," said Alan Guttmacher, director of the National Institute of Child Health and Human Development.

It was once widely assumed that, aside from cigarette smoke, drugs and excessive alcohol, the uterus, or womb, sheltered the fetus from environmental influences. Scientists also thought that the growing fetus could siphon off necessary nutrients from a mother like a parasite to ensure its survival.

Two decades of research into the fetal origins of disease, however, have challenged both assumptions and led to a revolutionary shift into the thinking about health and development.

According to Barker's widely accepted fetal origins theory, also referred to as the developmental origins of health and disease, stressors in the womb can permanently change a fetus's body structure, physiology and metabolism. Those changes then can lead to a higher risk of illness in the future.

Though some research looks at the effects of environmental exposures and psychological stress, much attention centers on nutrient deprivation, which occurs when the mother isn't getting amino acids, glucose and lipids to the developing baby quickly enough to meet its growing needs.

For example, most pancreatic beta cells -- they produce the insulin that regulates blood sugar -- are produced during fetal life, said Dr. Susan Ozanne, a British Heart Foundation senior fellow at the University of Cambridge. If the environment in the womb is suboptimal, as when a mother isn't getting enough protein to the fetus, the baby can wind up with fewer beta cells.

"This causes us problems later on, particularly if we place high demands on our body to produce insulin by becoming obese or eating high-sugar diets. Then we don't have enough beta cells to produce the amount of insulin we need," Ozanne said.

Nourishing a fetus, however, involves more than just eating the right foods. A woman's body composition also can affect how well her placenta transfers nutrients to the fetus.

"Different types of women provide different levels of access to her nutrients," said Kent Thornburg, director of the Heart Research Center at Oregon Health and Science University. "Thin mothers with low amounts of muscle are less able to handle protein than more muscular women, for example. Women who carry large amounts of fat are in a constant state of mild inflammation, which affects the formation and function of the placenta."

Fetal programming may work in at least two ways. One is that nutrient deprivation may simply stunt the growth of organs or tissue.

If a fetus can't get enough nutrients, scientists believe, it adapts by diverting sustenance to organs crucial for survival, such as the brain and heart. That can compromise other organs, such as the kidneys, lungs and pancreas, leaving the developing baby more vulnerable to illness down the road.

"The idea of the human baby as an efficient extraction of nutrients from mother is completely wrong," said Barker, also a professor of medicine at Oregon Health and Science University. Muscle growth also can be sacrificed, as an undernourished fetus will try to maintain levels of blood glucose by making its muscles resistant to the effects of insulin. This thrifty handling of sugar turns into a liability after birth, when sugar from freely available food floods the blood and obesity can make the body even more resistant to insulin, which leads to diabetes.

The other proposed mechanism is epigenetics, a process by which stressors modify the body's DNA in ways that affect the functioning of key genes.

Ozanne and her colleagues at Cambridge found that rat pups whose mothers ate a low-protein diet during pregnancy had low levels of activity of a gene called HNF4. That "leads to a reduction in the number of pancreatic beta cells that develop in the fetus, making them less able to produce sufficient levels of insulin in adulthood," Ozanne said.

Fetal exposure to the stress hormone cortisol appears to trigger both processes.

The placenta normally shields a fetus from exposure to cortisol, but if a mother is chronically stressed -- constantly in fight-or-flight mode -- it can't produce enough enzymes to do the job. If the fetus is exposed, Thornburg said, cortisol not only slows growth in most organs, "it also modifies genes through epigenetic mechanisms to make them lose their protective functions."

Chicago's Sara Strother, 30, who is due in December, said she keeps her stress levels down with yoga and avoids pesticides, plastic containers, cigarette smoke, alcohol, chemicals found in commercial cleaning products, airplanes (because of radiation exposure), even people with negative attitudes.

"You name it, I am paranoid," Strother said during a recent Mother Me childbirth education class at Sweet Pea's Studio in Chicago.

Early in Strother's pregnancy, she bought a juicer and binged on carrot juice. She then panicked after reading that high doses of vitamin A could be harmful. Her midwife eased her concerns: Carrots are OK. High doses of vitamin A supplements may not be.

Elstein, a recruiter, said she also tries to be careful about what she eats, drinks and inhales. She holds her breath around buses and moved out of the house for two days when a room was painted. "I'm so scared something will go wrong and I will blame myself, so I cope by trying to control what I can to ease my concerns."

Eventually, she talked to a therapist who reminded her that many people have babies in less than ideal circumstances and things work out.

"That's what I try to remind myself when I get nervous or scared," she said. "The cells are dividing and there's nothing I can do to stop this train from leaving the station."

jdeardorff@tribune.com

Twitter @Juliedeardorff

©2011 the Chicago Tribune

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Test All Kids for Cholesterol

Posted Nov 16, 2011

Every child should be tested for high cholesterol between ages 9 and 11 so steps can be taken to prevent heart disease later on, a panel of doctors urged Friday in new advice that is sure to be controversial.

Until now, major medical groups have suggested cholesterol tests only for children with a family history of early heart disease or high cholesterol and those who are obese or have diabetes or high blood pressure. But studies show that is missing many children with high cholesterol, and the number of them at risk is growing because of the obesity epidemic.

The recommendation is in new guidelines from an expert panel appointed by the National Heart, Lung and Blood Institute and endorsed by the American Academy of Pediatrics.

They also advise diabetes screening every two years starting as early as 9 for children who are overweight and have other risks for Type 2 diabetes, including family history. One third of U.S. children and teens are obese or overweight, fueling a boom in diabetes.

Autopsy studies show that some children already have signs of heart disease even before they have symptoms. By the fourth grade, 10 percent to 13 percent of U.S. children have high cholesterol, defined as a score of 200 or more.

Fats build up in the heart arteries in the first and second decade of life but usually don’t start hardening the arteries until people are in their 20s and 30s, said one of the guideline panel members, Dr. Elaine Urbina, director of preventive cardiology at Cincinnati Children’s Hospital Medical Center.

“If we screen at age 20, it may be already too late,” she said. “To me it’s not controversial at all. We should have been doing this for years.”

Elizabeth Duruz didn’t want to take that chance. Her 10-year-old daughter, Joscelyn Benninghoff, has been on cholesterol-lowering medicines since she was 5 because high cholesterol runs in her family. They live in Cincinnati.

“We decided when she was 5 that we would get her screened early on. She tested really high” despite being active and not overweight, Duruz said. “We’re doing what we need to do for her now and that gives me hope that she’ll be healthy.”

Doctors recommend screening between ages 9 and 11 because cholesterol dips during puberty and rises later. They also advise testing again later, between ages 17 and 21.

The guidelines say that cholesterol drugs likely would be recommended for less than 1 percent of kids tested. Most children found to have high cholesterol would be advised to control it with diet and physical activity.

And children younger than 10 should not be treated with cholesterol drugs unless they have severe cholesterol problems, the guidelines say.

“We’ll also continue to encourage parents and children to make positive lifestyle choices to prevent risk factors from occurring,” said Dr. Gordan Tomaselli, president of the American Heart Association, which praised the guidelines and will host a presentation on them Sunday at its annual conference in Florida.

Cholesterol tests cost around $80 and usually are covered by health insurance.

Several doctors on the guidelines panel have received consulting fees or have had other financial ties to makers of cholesterol medicines, and the new advice raises concerns about overtreating children with powerful drugs without long-term evidence about potential effects from decades of use.

Typically, cholesterol drugs are used indefinitely but they are generally safe, said Dr. Sarah Blumenschein, director of preventive cardiology at Children’s Medical Center in Dallas.

“You have to start early. It’s much easier to change children’s behavior when they’re 5, or 10, or 12″ than when they’re older, said Blumenschein, who treats many children with high cholesterol and supports the screening advice.

A different group of government advisers, the U.S. Preventive Services Task Force, concluded in 2007 that there’s not enough known about the possible benefits and harms to recommend for or against cholesterol screening for children and teens.

One of its leaders, Dr. Michael LeFevre, a family medicine specialist at the University of Missouri, said that for the task force to say screening is beneficial there must be evidence that treatment improves health, such as preventing heart attacks, rather than just nudges down a number – the cholesterol score.

“Some of the argument is that we need to treat children when they’re 14 or 15 to keep them from having a heart attack when they’re 50, and that’s a pretty long lag time,” he said.

The guidelines also say doctors should:

-Take yearly blood pressure measurements for children starting at age 3.

-Start routine anti-smoking advice when kids are ages 5 to 9, and counsel parents of infants not to smoke in the home.

-Review infants’ family history of obesity and start tracking body mass index, or BMI, a measure of obesity, at age 2.

The panel also suggests using more frank terms for kids who are overweight and obese than some government agencies have used in the past. Children whose BMI is in the 85th to 95th percentile should be called overweight, not “at risk for overweight,” and kids whose BMI is in the 95th percentile or higher should be called obese, not “overweight – even kids as young as age 2, the panel said.

“Some might feel that `obese’ is an unacceptable term for children and parents,” so doctors should “use descriptive terminology that is appropriate for each child and family,” the guidelines recommend.

They were released online Friday by the journal Pediatrics.

Marchione reported from Milwaukee and can be followed at http://twitter.com/MMarchioneAP

Online:

Guidelines: http://tinyurl.com/7csojas

NHLBI panel: http://www.nhlbi.nih.gov/guidelines/cvd_ped/index.htm

Cholesterol info: http://tinyurl.com/23dtxvo

and http://www.nhlbi.nih.gov/health/public/heart/index.htm(hash)chol

Every child should be tested for high cholesterol between ages 9 and 11 so steps can be taken to prevent heart disease later on, a panel of doctors urged Friday in new advice that is sure to be controversial.

Until now, major medical groups have suggested cholesterol tests only for children with a family history of early heart disease or high cholesterol and those who are obese or have diabetes or high blood pressure. But studies show that is missing many children with high cholesterol, and the number of them at risk is growing because of the obesity epidemic.

The recommendation is in new guidelines from an expert panel appointed by the National Heart, Lung and Blood Institute and endorsed by the American Academy of Pediatrics.

They also advise diabetes screening every two years starting as early as 9 for children who are overweight and have other risks for Type 2 diabetes, including family history. One third of U.S. children and teens are obese or overweight, fueling a boom in diabetes.

Autopsy studies show that some children already have signs of heart disease even before they have symptoms. By the fourth grade, 10 percent to 13 percent of U.S. children have high cholesterol, defined as a score of 200 or more.

Fats build up in the heart arteries in the first and second decade of life but usually don't start hardening the arteries until people are in their 20s and 30s, said one of the guideline panel members, Dr. Elaine Urbina, director of preventive cardiology at Cincinnati Children's Hospital Medical Center.

"If we screen at age 20, it may be already too late," she said. "To me it's not controversial at all. We should have been doing this for years."

Elizabeth Duruz didn't want to take that chance. Her 10-year-old daughter, Joscelyn Benninghoff, has been on cholesterol-lowering medicines since she was 5 because high cholesterol runs in her family. They live in Cincinnati.

"We decided when she was 5 that we would get her screened early on. She tested really high" despite being active and not overweight, Duruz said. "We're doing what we need to do for her now and that gives me hope that she'll be healthy."

Doctors recommend screening between ages 9 and 11 because cholesterol dips during puberty and rises later. They also advise testing again later, between ages 17 and 21.

The guidelines say that cholesterol drugs likely would be recommended for less than 1 percent of kids tested. Most children found to have high cholesterol would be advised to control it with diet and physical activity.

And children younger than 10 should not be treated with cholesterol drugs unless they have severe cholesterol problems, the guidelines say.

"We'll also continue to encourage parents and children to make positive lifestyle choices to prevent risk factors from occurring," said Dr. Gordan Tomaselli, president of the American Heart Association, which praised the guidelines and will host a presentation on them Sunday at its annual conference in Florida.

Cholesterol tests cost around $80 and usually are covered by health insurance.

Several doctors on the guidelines panel have received consulting fees or have had other financial ties to makers of cholesterol medicines, and the new advice raises concerns about overtreating children with powerful drugs without long-term evidence about potential effects from decades of use.

Typically, cholesterol drugs are used indefinitely but they are generally safe, said Dr. Sarah Blumenschein, director of preventive cardiology at Children's Medical Center in Dallas.

"You have to start early. It's much easier to change children's behavior when they're 5, or 10, or 12" than when they're older, said Blumenschein, who treats many children with high cholesterol and supports the screening advice.

A different group of government advisers, the U.S. Preventive Services Task Force, concluded in 2007 that there's not enough known about the possible benefits and harms to recommend for or against cholesterol screening for children and teens.

One of its leaders, Dr. Michael LeFevre, a family medicine specialist at the University of Missouri, said that for the task force to say screening is beneficial there must be evidence that treatment improves health, such as preventing heart attacks, rather than just nudges down a number - the cholesterol score.

"Some of the argument is that we need to treat children when they're 14 or 15 to keep them from having a heart attack when they're 50, and that's a pretty long lag time," he said.

The guidelines also say doctors should:

-Take yearly blood pressure measurements for children starting at age 3.

-Start routine anti-smoking advice when kids are ages 5 to 9, and counsel parents of infants not to smoke in the home.

-Review infants' family history of obesity and start tracking body mass index, or BMI, a measure of obesity, at age 2.

The panel also suggests using more frank terms for kids who are overweight and obese than some government agencies have used in the past. Children whose BMI is in the 85th to 95th percentile should be called overweight, not "at risk for overweight," and kids whose BMI is in the 95th percentile or higher should be called obese, not "overweight - even kids as young as age 2, the panel said.

"Some might feel that `obese' is an unacceptable term for children and parents," so doctors should "use descriptive terminology that is appropriate for each child and family," the guidelines recommend.

They were released online Friday by the journal Pediatrics.

Marchione reported from Milwaukee and can be followed at http://twitter.com/MMarchioneAP

Online:

Guidelines: http://tinyurl.com/7csojas

NHLBI panel: http://www.nhlbi.nih.gov/guidelines/cvd_ped/index.htm

Cholesterol info: http://tinyurl.com/23dtxvo

and http://www.nhlbi.nih.gov/health/public/heart/index.htm(hash)chol

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10 Things About Breast Cancer Prevention

Posted October 7, 2011

1- A lot of people talk about preventing breast cancer, but the correct term is risk reduction.

“We don’t really know how to prevent breast cancer. We know how to reduce people’s risks,” said Judith Swasey, a nurse practitioner at UNC Chapel Hill’s cancer hospital. The basics: Don’t smoke, exercise a lot, watch your diet, annual screenings.

2- There has been lots of controversy in recent years over the usefulness of annual mammograms for some women. Some researchers suggest they aren’t needed until women reach 50 and that it’s OK for women not at high risk to have scans every other year.

But the American Cancer Society and many breast cancer centers continue to recommend annual mammograms starting at 40. The cancer society also recommends clinical breast exams by physicians annually, beginning at the same age as mammograms.

For those at high risk for breast cancer because of family history, annual screening should begin before age 40. For example, if you have a sister who developed breast cancer at 45, the recommendation is to start mammograms at 35.

Monthly self-exams have also been the subject of debate, but the cancer society recommends them for women starting in their 20s.

Mammograms are controversial partly because they produce both benefit and harm. Awareness and screening have led to more early detection. But critics say that some patients have been harmed by unneeded surgery, radiation and chemotherapy for small cancers that wouldn’t have been found without mammography and wouldn’t have caused problems.

3- Post-menopause weight gain is particularly dangerous when it comes to breast cancer risk. With extra body fat comes more estrogen, which can stimulate breast cancer growth. A normal body mass index is less than 30.

To calculate BMI, multiply your height in inches by that same number; divide that total into your weight in pounds; then multiply the total by 703. A person who is 5-feet-5 (65 inches) and weighs 150 pounds has a body mass index of 25. (Or Google “BMI calculator” for an online tool.)

4- Many studies have looked for a link between diet and breast cancer risk, but results are conflicting.

Experts say it’s good advice to eat a diet high in fruits, vegetables and whole grains, and low in fat and red meat. “That’s what I tell my patients,” Swasey said. “Whatever diet is heart-healthy is probably the best one to follow.”

5- Evidence is growing that regular exercise lowers the risk of breast cancer. “It doesn’t have to be high-intensity exercise,” said Rachel Burns, dietitian with Levine Cancer Institute at Carolinas Medical Center. “It can be as easy as just walking, being physically active 30 minutes a day.”

6- Avoid soy supplements, Burns said. Soy contains isoflavones, which can act like estrogen and stimulate the growth of certain types of breast cancer. Supplements usually contain more concentrated doses of isoflavones than whole forms of soy, such as soy milk, tofu or edamame, Burns said. “Three servings a day of those (whole) forms are OK.”

7- Smoking hasn’t been linked specifically to breast cancer risk, but a recent study of women at high risk for breast cancer found that, for those who smoked, the more they smoked and the longer they smoked, the more their risk increased, Swasey said.

8- MRI scans are not recommended as regular screening tools for the general population. But they are used, in addition to mammography, for screening high-risk patients and for diagnosis after mammograms that detect suspicious masses.

9- Women with dense breasts are at higher risk for breast cancer, and mammograms aren’t as effective in detecting cancer in very dense breasts. Ask your doctor whether you have dense breasts and, if so, you might benefit from regular MRI scans or ultrasounds along with mammography.

10- Breast cancer risk goes up with age. The often-repeated statistic that “1 in 8″ women will get breast cancer is calculated over a lifetime to age 95. The National Cancer Institute has created a Breast Cancer Risk Assessment Tool. Take the test at

www.cancer.gov/bcrisktool.

Copyright 2011 The Charlotte Observer. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

©2011 The Charlotte Observer (Charlotte, N.C.)

1- A lot of people talk about preventing breast cancer, but the correct term is risk reduction.

"We don't really know how to prevent breast cancer. We know how to reduce people's risks," said Judith Swasey, a nurse practitioner at UNC Chapel Hill's cancer hospital. The basics: Don't smoke, exercise a lot, watch your diet, annual screenings.

2- There has been lots of controversy in recent years over the usefulness of annual mammograms for some women. Some researchers suggest they aren't needed until women reach 50 and that it's OK for women not at high risk to have scans every other year.

But the American Cancer Society and many breast cancer centers continue to recommend annual mammograms starting at 40. The cancer society also recommends clinical breast exams by physicians annually, beginning at the same age as mammograms.

For those at high risk for breast cancer because of family history, annual screening should begin before age 40. For example, if you have a sister who developed breast cancer at 45, the recommendation is to start mammograms at 35.

Monthly self-exams have also been the subject of debate, but the cancer society recommends them for women starting in their 20s.

Mammograms are controversial partly because they produce both benefit and harm. Awareness and screening have led to more early detection. But critics say that some patients have been harmed by unneeded surgery, radiation and chemotherapy for small cancers that wouldn't have been found without mammography and wouldn't have caused problems.

3- Post-menopause weight gain is particularly dangerous when it comes to breast cancer risk. With extra body fat comes more estrogen, which can stimulate breast cancer growth. A normal body mass index is less than 30.

To calculate BMI, multiply your height in inches by that same number; divide that total into your weight in pounds; then multiply the total by 703. A person who is 5-feet-5 (65 inches) and weighs 150 pounds has a body mass index of 25. (Or Google "BMI calculator" for an online tool.)

4- Many studies have looked for a link between diet and breast cancer risk, but results are conflicting.

Experts say it's good advice to eat a diet high in fruits, vegetables and whole grains, and low in fat and red meat. "That's what I tell my patients," Swasey said. "Whatever diet is heart-healthy is probably the best one to follow."

5- Evidence is growing that regular exercise lowers the risk of breast cancer. "It doesn't have to be high-intensity exercise," said Rachel Burns, dietitian with Levine Cancer Institute at Carolinas Medical Center. "It can be as easy as just walking, being physically active 30 minutes a day."

6- Avoid soy supplements, Burns said. Soy contains isoflavones, which can act like estrogen and stimulate the growth of certain types of breast cancer. Supplements usually contain more concentrated doses of isoflavones than whole forms of soy, such as soy milk, tofu or edamame, Burns said. "Three servings a day of those (whole) forms are OK."

7- Smoking hasn't been linked specifically to breast cancer risk, but a recent study of women at high risk for breast cancer found that, for those who smoked, the more they smoked and the longer they smoked, the more their risk increased, Swasey said.

8- MRI scans are not recommended as regular screening tools for the general population. But they are used, in addition to mammography, for screening high-risk patients and for diagnosis after mammograms that detect suspicious masses.

9- Women with dense breasts are at higher risk for breast cancer, and mammograms aren't as effective in detecting cancer in very dense breasts. Ask your doctor whether you have dense breasts and, if so, you might benefit from regular MRI scans or ultrasounds along with mammography.

10- Breast cancer risk goes up with age. The often-repeated statistic that "1 in 8" women will get breast cancer is calculated over a lifetime to age 95. The National Cancer Institute has created a Breast Cancer Risk Assessment Tool. Take the test at

www.cancer.gov/bcrisktool.

Copyright 2011 The Charlotte Observer. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

©2011 The Charlotte Observer (Charlotte, N.C.)

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