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IN THIS ISSUE:
  • Know About Celiac Disease

    Celiac disease is a hereditary autoimmune disease triggered by eating gluten-containing foods such as wheat, rye, and barley.

  • Diabetes Drugs Can Deplete Certain Nutrients

    Some medications can reduce levels of vitamins, minerals or gut flora which can lead to unwanted side effects.

  • More Magnesium May Make Sense

    Magnesium deficiency can contribute to anxiety, muscle weakness, and leg cramps and many common medications can deplete this vital mineral.

  • Pros and Cons of Going Totally Vegan

    Whether you decide to go vegan for health or environmental reasons, it is important to know what nutrients to pay close attention to for a balanced diet.

  • Getting Gout to Go Away

    Gout occurs when uric acid crystals form in one or more joints, but diet and lifestyle factors can help manage this painful condition.

  • Ancient Genetic Mutation Leads to B12 Deficiency

    This genetic discovery may help identify ethnic groups who may be at risk.

  • Living Successfully with Celiac Disease

    Celiac disease is an autoimmune disease that causes the body to attack the small intestine in response to consuming gluten. By avoiding this protein found mainly in wheat, rye, and barley, they can live healthy full lives.

  • Be Vitamin B12 Aware

    As people age their risk of developing a deficiency in vitamin B12 goes up. Low B12 can cause poor memory, nerve problems, and confusion.

  • Pick Your Produce

    Romaine, spinach, or iceburg? Which green gives us more nutrients per bite?

  • More Gluten Free Menu Options

    Restaurants are offering many more gluten free menu items for those who live with celiac disease.

  • Medication-Induced Nutrient Deficiencies

    Common medications may be causing millions of Americans to become nutrient deficient.

  • Folate Facts

    Folate is one of the B vitamins. Find out how much you know about it.

  • Folate Facts

    Test your knowledge on the B vitamin folate.

  • Brighten Up Your Plate for Better Health

    Eating a rainbow of colors can help ensure you are getting a wide variety of vitamins, minerals, and phytonutrients important to health.

  • Child Supplement Considerations

    Here are some things to consider and to look for when deciding if your child needs to supplement their diet.

  • Blocking This Enzyme May Lead to New Diabetes Therapy

    Researchers unexpectedly found that missing a specific enzyme can help mice burn off food faster than those who have the enzyme.

  • Yale Seeks Men for Testosterone Study

    Yale researchers are in search of older men to study the effects of testoterone therapy to see if they can reduce the risk of various health problems.

  • WIC To Get a Healthy Makeover

    The Women, Infants, and Children program has been around for a long time but it is just now handing out vouchers for fruits and vegetables.

  • You might be allergic to wheat and not know it
  • Iron Deficiency and Anemia

    There are other types of anemia, but iron deficiency is a common cause among young females.

  • Many Celiacs Go Undiagnosed

    Experts estimate that 1 in 133 people have celiac disease, but many do not even know that their suffering is from this increasingly common auto-immune condition.

  • Going Gluten Free May Help
  • Study to Examine Environment’s Impact on Kids’ Health

    Posted April 7, 2009 Starting this month, thousands of newly pregnant Utahns and potential mothers-to-be will be asked to enroll in the largest study of children ever conducted in the country. Parents who sign up for the National Children’s Study will join an effort to solve a new mystery in children’s health: How do kids’ [...]

  • Celiac Diagnosis Gives Life Back to Girl

    Posted Mar 26, 2009 Chelsea Wheeler, 6, had her first birthday cake at age 4 and her first take-out pizza only recently. The poignancy of those events isn’t lost on her parents, Chris and Linda Wheeler. Chelsea suffers from celiac disease, but it took so long to get to that diagnosis — including 20 unnecessary [...]

  • Find Enough Folate For Your Health

    Posted Mar 10, 2009 Folate, a vitamin that helps make the genetic material in cells and considered essential for pregnant women, may also help heart patients, a U.S. expert said. Janice Hermann, an Oklahoma State University Cooperative Extension nutrition specialist, said folate works with vitamin B12 to make red blood cells, assists in preventing neural [...]

Know About Celiac Disease

Posted May 17, 2013

The Academy of Nutrition and Dietetics (formerly the American Diatetic Association) issued the following news release:

Celiac disease is estimated to affect one out of 141 of Americans, or just under 1 percent of the population. The Academy of Nutrition and Dietetics encourages Americans to learn about celiac disease – it can affect your health or someone you love.

What is celiac disease? It is a hereditary, autoimmune disease caused by intolerance to the food protein, gluten – which is found in wheat, barley and rye. When people with celiac disease eat gluten-containing foods, the lining of the small intestine is damaged and eventually destroyed, preventing nutrients from being absorbed adequately. Untreated, celiac disease can lead to nutritional deficiencies, including anemia and osteoporosis, as well as other conditions, including other autoimmune diseases, intestinal cancers, infertility, delayed growth in children and failure to thrive in infants.

“While the only treatment for celiac disease is a gluten-free diet, the good news is, once the diet is started, the road to recover begins, and people with celiac disease can lead long, healthy lives,” says registered dietitian nutritionist and Academy spokesperson Rachel Begun. “Managing celiac disease is not just about eliminating gluten from your diet. It also entails ensuring you get all the vitamins and nutrients your body needs, such as iron, calcium, fiber and B-vitamins like thiamin, riboflavin, niacin and folate.”

An accurate diagnosis for celiac disease is a vital part of restoring health. Symptoms of celiac disease include bloating, gas or abdominal pain, chronic diarrhea or constipation, fatigue, itchy skin rash, tingling in hands and feet, delayed growth or fractured or thin bones. Some people are asymptomatic, meaning they do not experience any of these symptoms. If you or a loved one experience any of these conditions, it may be an indication of celiac disease.

“Do not diagnose yourself. If you have any symptoms, talk with your health care provider and get tested,” Begun says. “It’s important to keep eating a normal gluten-containing diet while being tested to ensure an accurate diagnosis. If you are diagnosed with celiac disease, a registered dietitian nutritionist will help you understand which foods are safe to eat and ensure you are getting the important nutrients your body needs.”

Many healthy foods are naturally gluten-free, such as fruits, vegetables, lean meats, poultry, fish, eggs, beans, legumes, soy, nuts, as well as the grains amaranth, buckwheat, corn, rice, teff and quinoa. Plus, there are a number of gluten-free flours made from almond meal, chickpeas and garbanzo beans, brown rice, coconut, potato, sorghum, tapioca and white rice.

For more information on celiac disease take a look at the Academy’s Celiac Disease resources, as well as the up-to-date, handy Gluten Detective App (https://www.eatright.org/shop/product.aspx?id=6442470637), which can simplify gluten-free grocery shopping, as well tips and tools to access on your smartphone.

Visit the Academy of Nutrition and Dietetics at www.eatright.org to locate a registered dietitian in your area.

TNS mv45 130511-4341443 61MarlynVitin

© 2013 Targeted News Service

The Academy of Nutrition and Dietetics (formerly the American Diatetic Association) issued the following news release:

Celiac disease is estimated to affect one out of 141 of Americans, or just under 1 percent of the population. The Academy of Nutrition and Dietetics encourages Americans to learn about celiac disease - it can affect your health or someone you love.

What is celiac disease? It is a hereditary, autoimmune disease caused by intolerance to the food protein, gluten - which is found in wheat, barley and rye. When people with celiac disease eat gluten-containing foods, the lining of the small intestine is damaged and eventually destroyed, preventing nutrients from being absorbed adequately. Untreated, celiac disease can lead to nutritional deficiencies, including anemia and osteoporosis, as well as other conditions, including other autoimmune diseases, intestinal cancers, infertility, delayed growth in children and failure to thrive in infants.

"While the only treatment for celiac disease is a gluten-free diet, the good news is, once the diet is started, the road to recover begins, and people with celiac disease can lead long, healthy lives," says registered dietitian nutritionist and Academy spokesperson Rachel Begun. "Managing celiac disease is not just about eliminating gluten from your diet. It also entails ensuring you get all the vitamins and nutrients your body needs, such as iron, calcium, fiber and B-vitamins like thiamin, riboflavin, niacin and folate."

An accurate diagnosis for celiac disease is a vital part of restoring health. Symptoms of celiac disease include bloating, gas or abdominal pain, chronic diarrhea or constipation, fatigue, itchy skin rash, tingling in hands and feet, delayed growth or fractured or thin bones. Some people are asymptomatic, meaning they do not experience any of these symptoms. If you or a loved one experience any of these conditions, it may be an indication of celiac disease.

"Do not diagnose yourself. If you have any symptoms, talk with your health care provider and get tested," Begun says. "It's important to keep eating a normal gluten-containing diet while being tested to ensure an accurate diagnosis. If you are diagnosed with celiac disease, a registered dietitian nutritionist will help you understand which foods are safe to eat and ensure you are getting the important nutrients your body needs."

Many healthy foods are naturally gluten-free, such as fruits, vegetables, lean meats, poultry, fish, eggs, beans, legumes, soy, nuts, as well as the grains amaranth, buckwheat, corn, rice, teff and quinoa. Plus, there are a number of gluten-free flours made from almond meal, chickpeas and garbanzo beans, brown rice, coconut, potato, sorghum, tapioca and white rice.

For more information on celiac disease take a look at the Academy's Celiac Disease resources, as well as the up-to-date, handy Gluten Detective App (https://www.eatright.org/shop/product.aspx?id=6442470637), which can simplify gluten-free grocery shopping, as well tips and tools to access on your smartphone.

Visit the Academy of Nutrition and Dietetics at www.eatright.org to locate a registered dietitian in your area.

TNS mv45 130511-4341443 61MarlynVitin

© 2013 Targeted News Service

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Diabetes Drugs Can Deplete Certain Nutrients

Posted March 3, 2013

Dear Pharmacist, I have your “Diabetes Without Drugs” book and it has helped me, but I’m still on two of the original 5 medications for this condition. What nutrients should I take with my medicine? — B.B., Micanopy, Fla.

For my new readers, the term “drug mugger” refers to how medication (or foods) reduce levels of vitamins, minerals and beneficial flora (probiotics) and cause side effects.

Metformin, which belongs to the biguanide class, depletes probiotics, vitamin B12 and folic acid. This deficiency may cause homocysteine to rise. You can measure homocysteine in the blood.

Up to 30 percent of people taking biguanide drugs (like metformin) experience poor absorption of vitamin B12, according to Diabetologia (1983) and withdrawal of this drug resulted in normal absorption in only half of those with malabsorption.

In other words, just taking the medicine means that half of you still need long-term B12 supplementation, because your B12 won’t automatically rise upon discontinuation of the drug.

Low B12 and folate could contribute or possibly cause tingling or numbness in the hands or feet (termed neuropathy), depression, megaloblastic anemia, weakness, rapid heart rate, confusion, memory loss, dementia, diarrhea/constipation, chronic fatigue, sciatica, as well as a higher risk of heart disease.

Do you think I’m telling you to stop your medicine? I’m not.

I am trying to keep you safe and help you learn what nutrients to put back. Replenishing what the drug mugger stole reduces your risk of side effects and remains compliant with your medication.

Hopefully your doctor has my book and has already told you to take a good B12 and folic acid supplement, as well as (and this is important) a good probiotic, because you require beneficial bacteria to manufacture B12.

Sulfonylureas (glipizide, glyburide, glimepiride) can increase the risk of CoQ10 deficiency according to a study in the Journal of Medicine. That can lead to fatigue, shortness of breath and heart arrhythmias.

info@dearpharmacist.com

Dear Pharmacist, I have your "Diabetes Without Drugs" book and it has helped me, but I'm still on two of the original 5 medications for this condition. What nutrients should I take with my medicine? -- B.B., Micanopy, Fla.

For my new readers, the term "drug mugger" refers to how medication (or foods) reduce levels of vitamins, minerals and beneficial flora (probiotics) and cause side effects.

Metformin, which belongs to the biguanide class, depletes probiotics, vitamin B12 and folic acid. This deficiency may cause homocysteine to rise. You can measure homocysteine in the blood.

Up to 30 percent of people taking biguanide drugs (like metformin) experience poor absorption of vitamin B12, according to Diabetologia (1983) and withdrawal of this drug resulted in normal absorption in only half of those with malabsorption.

In other words, just taking the medicine means that half of you still need long-term B12 supplementation, because your B12 won't automatically rise upon discontinuation of the drug.

Low B12 and folate could contribute or possibly cause tingling or numbness in the hands or feet (termed neuropathy), depression, megaloblastic anemia, weakness, rapid heart rate, confusion, memory loss, dementia, diarrhea/constipation, chronic fatigue, sciatica, as well as a higher risk of heart disease.

Do you think I'm telling you to stop your medicine? I'm not.

I am trying to keep you safe and help you learn what nutrients to put back. Replenishing what the drug mugger stole reduces your risk of side effects and remains compliant with your medication.

Hopefully your doctor has my book and has already told you to take a good B12 and folic acid supplement, as well as (and this is important) a good probiotic, because you require beneficial bacteria to manufacture B12.

Sulfonylureas (glipizide, glyburide, glimepiride) can increase the risk of CoQ10 deficiency according to a study in the Journal of Medicine. That can lead to fatigue, shortness of breath and heart arrhythmias.

info@dearpharmacist.com

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More Magnesium May Make Sense

Posted October 13, 2012

Dear Pharmacist, Dr. Oz said magnesium was the No. 1 thing for exhaustion. Do you agree? What are the best supplements? – C.T., Charlotte, N.C.

Magnesium is definitely needed for energy production. But no, I don’t agree it’s the “No. 1″ thing you need. Symptoms of mag deficiency include sugar and chocolate cravings, cardiac arrhythmias, irritability, panic attacks, anxiety, muscle weakness or spasms, tearfulness, depression, personality changes, constipation, leg cramps, and fatigue.

Your body needs mag all day long; some of it is used to fuel biochemical reactions, you urinate some out and require some to make dopamine (a happy brain chemical). Here’s what Dr. Oz didn’t say on that segment: Magnesium is leached by medications, something I’ve termed the “drug mugging” effect. More than 200 medications deplete mag, among them antacids, antibiotics, digoxin, heartburn/reflux medications, birth control, methylphenidate, corticosteroids, almost all blood pressure medications and diuretics.

There are other muggers too, including coffee, black and green tea, green coffee bean extract, and white refined sugar. Just having Celiac disease, Crohn’s, inflammatory bowel disease and chronic diarrhea can reduce magnesium.

Eating nutrient-dense foods is always my first choice to restore minerals, but in this case, eating magnesium-rich foods may not be enough to correct a serious deficiency. The best supplements are “chelated magnesium” or “magnesium glycinate” or my favorite “magnesium taurate.” That last one provides your body with both magnesium and taurine, and taurine is imperative for your heart cells!

My point is that fatigue is not usually due to low mag. There’s more involved, such as iron deficiency anemia, or poor B vitamin status. My column “Stressed Out?” can truly help you, so I’ve archived it at my site tulsaworld.com/Pharmacist

info@dearpharmacist.com

Dear Pharmacist, Dr. Oz said magnesium was the No. 1 thing for exhaustion. Do you agree? What are the best supplements? - C.T., Charlotte, N.C.

Magnesium is definitely needed for energy production. But no, I don't agree it's the "No. 1" thing you need. Symptoms of mag deficiency include sugar and chocolate cravings, cardiac arrhythmias, irritability, panic attacks, anxiety, muscle weakness or spasms, tearfulness, depression, personality changes, constipation, leg cramps, and fatigue.

Your body needs mag all day long; some of it is used to fuel biochemical reactions, you urinate some out and require some to make dopamine (a happy brain chemical). Here's what Dr. Oz didn't say on that segment: Magnesium is leached by medications, something I've termed the "drug mugging" effect. More than 200 medications deplete mag, among them antacids, antibiotics, digoxin, heartburn/reflux medications, birth control, methylphenidate, corticosteroids, almost all blood pressure medications and diuretics.

There are other muggers too, including coffee, black and green tea, green coffee bean extract, and white refined sugar. Just having Celiac disease, Crohn's, inflammatory bowel disease and chronic diarrhea can reduce magnesium.

Eating nutrient-dense foods is always my first choice to restore minerals, but in this case, eating magnesium-rich foods may not be enough to correct a serious deficiency. The best supplements are "chelated magnesium" or "magnesium glycinate" or my favorite "magnesium taurate." That last one provides your body with both magnesium and taurine, and taurine is imperative for your heart cells!

My point is that fatigue is not usually due to low mag. There's more involved, such as iron deficiency anemia, or poor B vitamin status. My column "Stressed Out?" can truly help you, so I've archived it at my site tulsaworld.com/Pharmacist

info@dearpharmacist.com

Tags: , , , , , , , , , , , , , , , , , , ,



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Pros and Cons of Going Totally Vegan

Posted May 26, 2012

Several high-profile public figures have made headlines recently about their decision to go vegan, spurring increased interest and debate about this plant-based diet plan.

Among them are Ellen DeGeneres, the Emmy award-winning comedian and her wife, actress Portia de Rossi, who have purged their diets of all animal products, including milk and eggs.

Former U.S. President Bill Clinton recently spoke with DeGeneres on her talk-variety show about his decision to adopt a vegan diet, too. Other famous vegans include: Carrie Underwood, Ted Danson, Mike Tyson, Alec Baldwin, Alicia Silverstone and Lea Michele.

Vegetarian vs. Vegan

According to a 2011 poll by The Vegetarian Resource Group, approximately 5 percent of adults in the U.S. say they are vegetarian, which means they never eat meat, fish, seafood or poultry.

About half of those vegetarians also are vegan, which means they also do not consume any animal products or by-products, according to the VRG.

In addition to staying away from flesh foods, dairy and eggs, vegans avoid fur, leather, wool, down and cosmetics or chemical products tested on animals for a variety of reasons, including those related to animal rights, the environment and health, according to Vegan Action, a nonprofit organization dedicated to educating the public about the benefits of a vegan lifestyle.

With the vegan lifestyle getting increased attention, we spoke to nine local experts and asked them to explain the pros and cons of this diet and lifestyle choice and how to make the change safely.

Benefits of vegan diet

Local dietitians said when done right, going vegan comes with numerous health perks.

Less fat, more fruits and veggies: Ellen Thompson, a registered, licensed dietitian in Ohio who is based out of Springfield and works throughout the Miami Valley, said vegans are removing saturated fats from their diet and are likely to eat more fruits and vegetables.

Decreased health risks: The vitamins and minerals in fruits and vegetables may lead to a decreased risk for certain types of cancer, said Carla Metzler, a registered, licensed dietitian who works at Fort Hamilton Hospital.

A vegan diet may prevent or reduce the risk of heart disease, diabetes and obesity, according to both Joan Wire, a registered, licensed dietitian in Ohio who runs a counseling business called Real Well and who works out of LaDeSpa in Oakwood, and Kathryn Hines, a registered, licensed dietitian in Ohio who works at Springfield Regional Medical Center.

Going vegan also may reduce the risk of high blood pressure, constipation, breast cancer, colon cancer, diverticular disease, gallstones, irritable bowel syndrome and appendicitis, said Mara Lamb, a registered, licensed dietitian who owns her own practice called Nutrition Therapy Clinic in Dayton.

Lower BMI: Vegans tend to have a lower body mass index and a lower amount of LDL cholesterol in their bodies, which clogs arteries, said Carol Nartker, a diabetes nutrition educator and a registered, licensed dietitian in Ohio who works at the Diabetes Wellness Center of Atrium Medical Center in Middletown.

In fact, “Forks over Knives,” a 2011 documentary, has recently drawn attention for examining the claim that most, and perhaps all, degenerative diseases can be controlled or eliminated by rejecting animal-based and processed foods, said Rich Cohen, a registered dietitian, licensed dietitian in Ohio, who works at Kettering Weight Loss Solutions within the Kettering Health Network.

“Our food supply is not very natural,” Cohen said. ” … The vegan diet seems to be offering perhaps some kind of a nutritional medicine approach, particularly with people with cardiovascular disease.”

Allergy, sinus relief? Wire also said individuals who turn to a vegan diet may realize allergy symptoms and sinus problems are reduced or eliminated once they stop consuming dairy.

Downsides of going vegan

On the other hand, there are potential negative health effects associated with going vegan, dietitians said.

Risk of deficiencies: According to Thompson, if a vegan is not careful, he or she may develop nutritional deficiencies due to a lack of dairy and meat products in their diet.

Some dietitians are concerned that vegans do not receive an adequate amount of amino acids, Vitamin B12, Vitamin D, Calcium, protein and iron, Thompson said.

Dr. Andrew Dyer, an associate clinician at Back to Health Center in Dayton, said protein deficiencies can lead to fatigue, a lack of energy and an inability to complete daily tasks, he said.

Additionally, those participating in exercise and athletics may have a difficult time healing and repairing post workout without getting enough protein in their diet, he said.

A lack of Vitamin B12 in a diet may lead to anemia, Nartker said.

Bone health: In addition, a lack of calcium may put a person at risk for developing a fragile bone structure, according to Metzler.

“Chronic nutritional deficiencies can affect the quality of one’s life, how they feel, how they function from day to day,” Nartker said.

What vegans should, should not eat

Vegans should avoid overly processed foods and choose whole foods, which are closer to “what Mother Nature intended” for people to consume, Wire recommends.

Vegans must minimize their intake of “junk food,” which includes sweets and snacks high in fat, Lamb said.

Acclimating to new tastes typically takes about three weeks, she said.

Importance of planning

Careful planning is key to ensuring a person adopts a long-term, healthy vegan diet, Thompson said. It’s also important that vegans remember that a healthy lifestyle means they get enough exercise and sleep, too, she said.

“It’s not what you do once in a while,” Thompson said. “It’s what you do every day.”

Start by doing research.

“Don’t go in cold turkey,” Wire said. ” … You could miss out on getting the right types of protein.”

Thompson said vegans should speak to a dietitian in order to make sure they are following a healthy diet plan.

New vegans should change their diet slowly, and should see a doctor if they have health issues such as diabetes, she said.

The Associated Press contributed to this story. Contact this reporter at (937) 225-2122 or Jacqueline.Boyle@coxinc.com.

©2012 the Dayton Daily News (Dayton, Ohio)

Visit the Dayton Daily News (Dayton, Ohio) at www.daytondailynews.com

Several high-profile public figures have made headlines recently about their decision to go vegan, spurring increased interest and debate about this plant-based diet plan.

Among them are Ellen DeGeneres, the Emmy award-winning comedian and her wife, actress Portia de Rossi, who have purged their diets of all animal products, including milk and eggs.

Former U.S. President Bill Clinton recently spoke with DeGeneres on her talk-variety show about his decision to adopt a vegan diet, too. Other famous vegans include: Carrie Underwood, Ted Danson, Mike Tyson, Alec Baldwin, Alicia Silverstone and Lea Michele.

Vegetarian vs. Vegan

According to a 2011 poll by The Vegetarian Resource Group, approximately 5 percent of adults in the U.S. say they are vegetarian, which means they never eat meat, fish, seafood or poultry.

About half of those vegetarians also are vegan, which means they also do not consume any animal products or by-products, according to the VRG.

In addition to staying away from flesh foods, dairy and eggs, vegans avoid fur, leather, wool, down and cosmetics or chemical products tested on animals for a variety of reasons, including those related to animal rights, the environment and health, according to Vegan Action, a nonprofit organization dedicated to educating the public about the benefits of a vegan lifestyle.

With the vegan lifestyle getting increased attention, we spoke to nine local experts and asked them to explain the pros and cons of this diet and lifestyle choice and how to make the change safely.

Benefits of vegan diet

Local dietitians said when done right, going vegan comes with numerous health perks.

Less fat, more fruits and veggies: Ellen Thompson, a registered, licensed dietitian in Ohio who is based out of Springfield and works throughout the Miami Valley, said vegans are removing saturated fats from their diet and are likely to eat more fruits and vegetables.

Decreased health risks: The vitamins and minerals in fruits and vegetables may lead to a decreased risk for certain types of cancer, said Carla Metzler, a registered, licensed dietitian who works at Fort Hamilton Hospital.

A vegan diet may prevent or reduce the risk of heart disease, diabetes and obesity, according to both Joan Wire, a registered, licensed dietitian in Ohio who runs a counseling business called Real Well and who works out of LaDeSpa in Oakwood, and Kathryn Hines, a registered, licensed dietitian in Ohio who works at Springfield Regional Medical Center.

Going vegan also may reduce the risk of high blood pressure, constipation, breast cancer, colon cancer, diverticular disease, gallstones, irritable bowel syndrome and appendicitis, said Mara Lamb, a registered, licensed dietitian who owns her own practice called Nutrition Therapy Clinic in Dayton.

Lower BMI: Vegans tend to have a lower body mass index and a lower amount of LDL cholesterol in their bodies, which clogs arteries, said Carol Nartker, a diabetes nutrition educator and a registered, licensed dietitian in Ohio who works at the Diabetes Wellness Center of Atrium Medical Center in Middletown.

In fact, "Forks over Knives," a 2011 documentary, has recently drawn attention for examining the claim that most, and perhaps all, degenerative diseases can be controlled or eliminated by rejecting animal-based and processed foods, said Rich Cohen, a registered dietitian, licensed dietitian in Ohio, who works at Kettering Weight Loss Solutions within the Kettering Health Network.

"Our food supply is not very natural," Cohen said. " ... The vegan diet seems to be offering perhaps some kind of a nutritional medicine approach, particularly with people with cardiovascular disease."

Allergy, sinus relief? Wire also said individuals who turn to a vegan diet may realize allergy symptoms and sinus problems are reduced or eliminated once they stop consuming dairy.

Downsides of going vegan

On the other hand, there are potential negative health effects associated with going vegan, dietitians said.

Risk of deficiencies: According to Thompson, if a vegan is not careful, he or she may develop nutritional deficiencies due to a lack of dairy and meat products in their diet.

Some dietitians are concerned that vegans do not receive an adequate amount of amino acids, Vitamin B12, Vitamin D, Calcium, protein and iron, Thompson said.

Dr. Andrew Dyer, an associate clinician at Back to Health Center in Dayton, said protein deficiencies can lead to fatigue, a lack of energy and an inability to complete daily tasks, he said.

Additionally, those participating in exercise and athletics may have a difficult time healing and repairing post workout without getting enough protein in their diet, he said.

A lack of Vitamin B12 in a diet may lead to anemia, Nartker said.

Bone health: In addition, a lack of calcium may put a person at risk for developing a fragile bone structure, according to Metzler.

"Chronic nutritional deficiencies can affect the quality of one's life, how they feel, how they function from day to day," Nartker said.

What vegans should, should not eat

Vegans should avoid overly processed foods and choose whole foods, which are closer to "what Mother Nature intended" for people to consume, Wire recommends.

Vegans must minimize their intake of "junk food," which includes sweets and snacks high in fat, Lamb said.

Acclimating to new tastes typically takes about three weeks, she said.

Importance of planning

Careful planning is key to ensuring a person adopts a long-term, healthy vegan diet, Thompson said. It's also important that vegans remember that a healthy lifestyle means they get enough exercise and sleep, too, she said.

"It's not what you do once in a while," Thompson said. "It's what you do every day."

Start by doing research.

"Don't go in cold turkey," Wire said. " ... You could miss out on getting the right types of protein."

Thompson said vegans should speak to a dietitian in order to make sure they are following a healthy diet plan.

New vegans should change their diet slowly, and should see a doctor if they have health issues such as diabetes, she said.

The Associated Press contributed to this story. Contact this reporter at (937) 225-2122 or Jacqueline.Boyle@coxinc.com.

©2012 the Dayton Daily News (Dayton, Ohio)

Visit the Dayton Daily News (Dayton, Ohio) at www.daytondailynews.com

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Getting Gout to Go Away

Posted March 6, 2012

What you should know

The pain caused by the disease of gout can be relieved with the right treatment, careful nutrition, weight loss and fluids.

Pain occurs when sharp uric acid crystals form in one or more joints. Uric acid is a body waste product that is passed through the kidneys into the urine. Crystals can occur in joints because the body makes too much uric acid or builds up too much uric acid rather than getting rid of it.

Lower joints such as a big toe, ankle or knee are most often affected. Gout is more common among overweight adult men and older women. Gout seems to run in some families.

Discomfort often starts at night. Anything touching the irritated joint – even a sock or sheet – can cause extreme pain. The joint can become swollen and warm.

An acute gout attack might last only a few days. However, without proper treatment, an acute attack can cause permanent joint damage. Permanent joint damage can lead to chronic attacks.

A doctor who specializes in arthritis (rheumatologist) can perform tests to diagnose whether you have gout. Diagnosis can involve testing a sample of joint fluid for crystals and white blood cells. Joints might be X-rayed and blood tests done to check the blood’s uric acid level.

The doctor can recommend the correct dose of a nonsteroidal anti- inflammatory drug (NSAID) to reduce pain and swelling. He or she might also prescribe a painkiller such as codeine and medicine like colchicine to reduce swelling. The swollen joint can also be treated with an injected steroid.

For chronic gout, the doctor might prescribe a medicine to reduce uric acid in the blood, such as allopurinol.

Gout treatment might also require changes in lifestyle.

Sometimes pseudogout is confused with gout or some other form of arthritis. In pseudogout, a type of salt crystal (calcium pyrophosphate dehydrate), not uric acid crystals, forms in the painful, swollen joint.

Many of the same medicines used for treating gout are generally effective for pseudogout. Treatment for both diseases might include removing excess fluid from a joint.

Other health conditions and medications increase the risk of a gout attack or make an attack worse. Patients who are dehydrated or take medicine to remove excess water (diuretics) due to hypertension could be at greater risk. Some other medicines can also increase risks. The chance of gout symptoms tends to be higher for people who are obese or who have diabetes, anemia, blood cancer, kidney disease or an underactive thyroid.

Gout can improve with a healthy diet. Certain eating habits can make gout worse. They include drinking alcohol and eating high-fat and purine-rich foods such as sardines, organ meats and brewers’ yeast. Brewers’ yeast is often used in breads, gravies, casseroles, dips, spreads and soups. Purines are a type of protein found in many foods. Foods that increase acid levels in the body might also increase risks.

At first, uric acid-lowering treatment might cause a joint to become sorer as crystal deposits break up in a joint.

What you should do

Take recommended medicines to reduce inflammation in a joint as soon as you have a gout attack. Ibuprofen (for example, Advil or Motrin) or naproxen (such as Aleve) helps many people.

Get professional help when symptoms occur. Visit your primary care provider to see if you need a rheumatologist.

Get serious about your lifestyle. Avoid things that can trigger attacks. Drink plenty of water to flush uric acid from your body. Avoid alcohol and animal proteins from meats and fatty and purine- rich foods.

Reduce the chances of more attacks by losing weight slowly but surely. Exercise regularly and eat small portions.

Be sure to include complex carbohydrates in your diet. A lack of carbohydrates can lead to ketosis, which can eventually increase the level of uric acid in your blood.

Get professional advice about medicine. Tell your care provider about the medicines and vitamins you are taking. Some, such as aspirin, niacin and diuretics, might be increasing your gout risks. Some anti-inflammatory medicines might be harmful if you have kidney disease or ulcers. Aspirin can also interfere with some uric-acid- lowering medications. Don’t just stop recommended medicines on your own.

Rest an inflamed joint. Use an ice pack to reduce pain and swelling.

For more information

Learn about gout at niams.nih.gov/Health_Info/ Gout/default.asp. See acumedico.com/purine.htm for a list of purine-rich foods to avoid.

Better Health: Take Charge! is provided by the Healthy Memphis Common Table: www.healthymemphis.org. This article supports the care and advice of your doctor.

What you should know

The pain caused by the disease of gout can be relieved with the right treatment, careful nutrition, weight loss and fluids.

Pain occurs when sharp uric acid crystals form in one or more joints. Uric acid is a body waste product that is passed through the kidneys into the urine. Crystals can occur in joints because the body makes too much uric acid or builds up too much uric acid rather than getting rid of it.

Lower joints such as a big toe, ankle or knee are most often affected. Gout is more common among overweight adult men and older women. Gout seems to run in some families.

Discomfort often starts at night. Anything touching the irritated joint - even a sock or sheet - can cause extreme pain. The joint can become swollen and warm.

An acute gout attack might last only a few days. However, without proper treatment, an acute attack can cause permanent joint damage. Permanent joint damage can lead to chronic attacks.

A doctor who specializes in arthritis (rheumatologist) can perform tests to diagnose whether you have gout. Diagnosis can involve testing a sample of joint fluid for crystals and white blood cells. Joints might be X-rayed and blood tests done to check the blood's uric acid level.

The doctor can recommend the correct dose of a nonsteroidal anti- inflammatory drug (NSAID) to reduce pain and swelling. He or she might also prescribe a painkiller such as codeine and medicine like colchicine to reduce swelling. The swollen joint can also be treated with an injected steroid.

For chronic gout, the doctor might prescribe a medicine to reduce uric acid in the blood, such as allopurinol.

Gout treatment might also require changes in lifestyle.

Sometimes pseudogout is confused with gout or some other form of arthritis. In pseudogout, a type of salt crystal (calcium pyrophosphate dehydrate), not uric acid crystals, forms in the painful, swollen joint.

Many of the same medicines used for treating gout are generally effective for pseudogout. Treatment for both diseases might include removing excess fluid from a joint.

Other health conditions and medications increase the risk of a gout attack or make an attack worse. Patients who are dehydrated or take medicine to remove excess water (diuretics) due to hypertension could be at greater risk. Some other medicines can also increase risks. The chance of gout symptoms tends to be higher for people who are obese or who have diabetes, anemia, blood cancer, kidney disease or an underactive thyroid.

Gout can improve with a healthy diet. Certain eating habits can make gout worse. They include drinking alcohol and eating high-fat and purine-rich foods such as sardines, organ meats and brewers' yeast. Brewers' yeast is often used in breads, gravies, casseroles, dips, spreads and soups. Purines are a type of protein found in many foods. Foods that increase acid levels in the body might also increase risks.

At first, uric acid-lowering treatment might cause a joint to become sorer as crystal deposits break up in a joint.

What you should do

Take recommended medicines to reduce inflammation in a joint as soon as you have a gout attack. Ibuprofen (for example, Advil or Motrin) or naproxen (such as Aleve) helps many people.

Get professional help when symptoms occur. Visit your primary care provider to see if you need a rheumatologist.

Get serious about your lifestyle. Avoid things that can trigger attacks. Drink plenty of water to flush uric acid from your body. Avoid alcohol and animal proteins from meats and fatty and purine- rich foods.

Reduce the chances of more attacks by losing weight slowly but surely. Exercise regularly and eat small portions.

Be sure to include complex carbohydrates in your diet. A lack of carbohydrates can lead to ketosis, which can eventually increase the level of uric acid in your blood.

Get professional advice about medicine. Tell your care provider about the medicines and vitamins you are taking. Some, such as aspirin, niacin and diuretics, might be increasing your gout risks. Some anti-inflammatory medicines might be harmful if you have kidney disease or ulcers. Aspirin can also interfere with some uric-acid- lowering medications. Don't just stop recommended medicines on your own.

Rest an inflamed joint. Use an ice pack to reduce pain and swelling.

For more information

Learn about gout at niams.nih.gov/Health_Info/ Gout/default.asp. See acumedico.com/purine.htm for a list of purine-rich foods to avoid.

Better Health: Take Charge! is provided by the Healthy Memphis Common Table: www.healthymemphis.org. This article supports the care and advice of your doctor.

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Ancient Genetic Mutation Leads to B12 Deficiency

Posted Dec 30, 2011

–Ohio State University researchers have found what they believe is the second-oldest-known genetic disease mutation.

The mutation causes a disorder known as Imerslund-Grasbeck syndrome, a rare and dangerous deficiency of vitamin B12.

The mutation is about 13,600 years old and originated in the Middle East, according to a research team led by Stephan M. Tanner, a researcher in the Comprehensive Cancer Center’s human cancer genetics program.

It is now seen in people of Arabic, Jewish and Turkish ancestry. More-recent genetic disease mutations of this type often are found within a single group, such as the Amish, Tanner said.

The discovery is remarkable for its historic value, but it also might play an important role in identifying the disease in people of certain ethnic backgrounds, said Tanner, an assistant professor of molecular virology, immunology and medical genetics.

The oldest-known genetic disease mutation is linked to cystic fibrosis and first showed up as long as 52,000 years ago.

The work of Tanner’s team started with genetic samples from an Israeli family and eventually included samples from 16 affected families.

Scientists used a complex analysis to estimate the age of the mutation, including looking at the size of the section of the chromosome on which the mutation appears. As a mutation is passed down through generations, the section on which it is located gets shorter.

Only about 500 cases of Imerslund-Grasbeck syndrome have been identified worldwide. But Tanner said it is unclear how common the disorder is because people might be treated for B12 deficiency even though no specific disorder has been diagnosed. There are many causes for the deficiency.

The syndrome can cause anemia, growth problems, increased risk of infection and impaired neurological development. It is a recessive disorder. That means, if a mother and father are both carriers, there’s a 25 percent chance the disorder will show up in each of their children.

Dr. John C. Fyfe, a veterinarian and associate professor of microbiology and molecular genetics at Michigan State University, said the research is important to genetic science in general.

More specifically, it could help the families affected by the disease, said Fyfe, who studies the disorder in dogs. A pediatrician assessing a B12 deficiency in a 2-year-old child of Turkish descent, for example, would have a strong clue what the diagnosis might be, he said.

Imerslund-Grasbeck syndrome was first identified 50 years ago. The mutation discovered by the Ohio State team is responsible for half of the cases in Arabic, Turkish and Jewish people and 15 percent of all cases that have been studied, Tanner said.

Commercially, a test for a specific mutation such as this might cost about $500, he said. Broader genetic testing to try to figure out what was causing the deficiency would run several thousand dollars.

Parents who know they’re carriers of the mutation can identify the syndrome more quickly when a child is born and begin monthly B12 shots, a relatively simple — and highly effective — treatment. Early treatment prevents more-severe, lingering neurological problems.

The research was published in the Orphanet Journal of Rare Diseases.

mcrane@dispatch.com

©2011 The Columbus Dispatch (Columbus, Ohio)

Visit The Columbus Dispatch (Columbus, Ohio) at www.dispatch.com Distributed by MCT Information Services

Posted Dec 30, 2011

--Ohio State University researchers have found what they believe is the second-oldest-known genetic disease mutation.

The mutation causes a disorder known as Imerslund-Grasbeck syndrome, a rare and dangerous deficiency of vitamin B12.

The mutation is about 13,600 years old and originated in the Middle East, according to a research team led by Stephan M. Tanner, a researcher in the Comprehensive Cancer Center's human cancer genetics program.

It is now seen in people of Arabic, Jewish and Turkish ancestry. More-recent genetic disease mutations of this type often are found within a single group, such as the Amish, Tanner said.

The discovery is remarkable for its historic value, but it also might play an important role in identifying the disease in people of certain ethnic backgrounds, said Tanner, an assistant professor of molecular virology, immunology and medical genetics.

The oldest-known genetic disease mutation is linked to cystic fibrosis and first showed up as long as 52,000 years ago.

The work of Tanner's team started with genetic samples from an Israeli family and eventually included samples from 16 affected families.

Scientists used a complex analysis to estimate the age of the mutation, including looking at the size of the section of the chromosome on which the mutation appears. As a mutation is passed down through generations, the section on which it is located gets shorter.

Only about 500 cases of Imerslund-Grasbeck syndrome have been identified worldwide. But Tanner said it is unclear how common the disorder is because people might be treated for B12 deficiency even though no specific disorder has been diagnosed. There are many causes for the deficiency.

The syndrome can cause anemia, growth problems, increased risk of infection and impaired neurological development. It is a recessive disorder. That means, if a mother and father are both carriers, there's a 25 percent chance the disorder will show up in each of their children.

Dr. John C. Fyfe, a veterinarian and associate professor of microbiology and molecular genetics at Michigan State University, said the research is important to genetic science in general.

More specifically, it could help the families affected by the disease, said Fyfe, who studies the disorder in dogs. A pediatrician assessing a B12 deficiency in a 2-year-old child of Turkish descent, for example, would have a strong clue what the diagnosis might be, he said.

Imerslund-Grasbeck syndrome was first identified 50 years ago. The mutation discovered by the Ohio State team is responsible for half of the cases in Arabic, Turkish and Jewish people and 15 percent of all cases that have been studied, Tanner said.

Commercially, a test for a specific mutation such as this might cost about $500, he said. Broader genetic testing to try to figure out what was causing the deficiency would run several thousand dollars.

Parents who know they're carriers of the mutation can identify the syndrome more quickly when a child is born and begin monthly B12 shots, a relatively simple -- and highly effective -- treatment. Early treatment prevents more-severe, lingering neurological problems.

The research was published in the Orphanet Journal of Rare Diseases.

mcrane@dispatch.com

©2011 The Columbus Dispatch (Columbus, Ohio)

Visit The Columbus Dispatch (Columbus, Ohio) at www.dispatch.com Distributed by MCT Information Services

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Living Successfully with Celiac Disease

Posted Nov 30, 2011

People who have celiac disease — a genetic disorder that damages the small intestine and interferes with the absorption of nutrients from food — must maintain a gluten-free diet for the rest of their lives in order to remain free of symptoms, said to Angie Sutphin, a dietitian at Western Maryland Health System.

There is no cure, pharmaceutical or otherwise, for the disease, the only treatment is a gluten-free diet.

Sutphin said that people dealing with celiac disease should learn to read labels carefully to see if the product contains gluten.

Gluten is found in food that contains wheat, rye or barley, ingredients in most grain, pasta, cereal and many processed foods, according to the National Digestive Diseases Information Clearinghouse (NDDIC).

Oats should be avoided as well because they often become contaminated after being stored in the same silos as wheat, rye and barley, according to Dr. William Mark, a gastroenterologist in Cumberland.

Gluten is also used in some medications.

“Don’t think of your condition as a death sentence. With practice and patience, you will find there are many foods you can enjoy on a gluten-free diet,” said Sutphin.

Gluten-free foods are not difficult to find. They include flours that are made of rice, soy, corn, potato or bean; nut flours (almond); quinoa; fresh meats, fish and poultry (not breaded, batter-coated or marinated); fruits; most dairy products; potatoes; rice and vegetables, according to Sutphin.

Foods other than beans, rice, potatoes and produce that are marked gluten-free typically tend to be more expensive, though most grocery stores have a gluten-free section, according to Mark.

Mark provides his patients with a list of food they are not advised to consume, as well as a list to replace those foods.

For most people, following this diet will stop symptoms of celiac disease, heal existing intestinal damage and prevent further damage.

Improvement begins within days of starting the diet, according to NDDIC.

The small intestine usually heals in three to six months in children but may take several years in adults.

Eating a gluten-free diet also helps lessen the symptoms of people with autism and schizophrenia, according to Mark.

“I don’t have celiac disease and I wouldn’t consume gluten. It’s poisonous to your whole body,” said Mark. “I have seen patients that have had hives for 20 years that go away after they stop eating gluten.”

Symptoms of celiac disease vary from person to person but can include abdominal bloating and pain; chronic diarrhea, vomiting, constipation and weight loss. These symptoms are more common in infants and children, according to the NDDIC.

Some symptoms common in adults include unexplained iron-deficiency anemia; fat-igue; joint or bone pain; arthritis; seizures; missed menstrual periods, infertility or recurrent miscarriage.

Celiac disease is diagnosed through blood tests and intestinal biopsies.

Fifteen to 25 percent of the people who have the disease also have dermatitis herpetiforms, an intensely itchy blistering skin rash that usually occurs on the elbows, knees and buttocks, according to NDDIC.

Celiac disease affects one in 133 people, according to Sutphin. Among people who have a first-degree relative — a parent, sibling or child — diagnosed with celiac disease, as many as one in 22 people may have the disease, according to NDDIC. However, people can still have the disease even though no one in their family has it.

Other times, the gene exists but the body is able to prevent the disease from manifesting, according to Mark.

Contact Elaine Blaisdell at eblaisdell@times-news.com.

©2011 the Cumberland Times News (Cumberland, Md.)

People who have celiac disease -- a genetic disorder that damages the small intestine and interferes with the absorption of nutrients from food -- must maintain a gluten-free diet for the rest of their lives in order to remain free of symptoms, said to Angie Sutphin, a dietitian at Western Maryland Health System.

There is no cure, pharmaceutical or otherwise, for the disease, the only treatment is a gluten-free diet.

Sutphin said that people dealing with celiac disease should learn to read labels carefully to see if the product contains gluten.

Gluten is found in food that contains wheat, rye or barley, ingredients in most grain, pasta, cereal and many processed foods, according to the National Digestive Diseases Information Clearinghouse (NDDIC).

Oats should be avoided as well because they often become contaminated after being stored in the same silos as wheat, rye and barley, according to Dr. William Mark, a gastroenterologist in Cumberland.

Gluten is also used in some medications.

"Don't think of your condition as a death sentence. With practice and patience, you will find there are many foods you can enjoy on a gluten-free diet," said Sutphin.

Gluten-free foods are not difficult to find. They include flours that are made of rice, soy, corn, potato or bean; nut flours (almond); quinoa; fresh meats, fish and poultry (not breaded, batter-coated or marinated); fruits; most dairy products; potatoes; rice and vegetables, according to Sutphin.

Foods other than beans, rice, potatoes and produce that are marked gluten-free typically tend to be more expensive, though most grocery stores have a gluten-free section, according to Mark.

Mark provides his patients with a list of food they are not advised to consume, as well as a list to replace those foods.

For most people, following this diet will stop symptoms of celiac disease, heal existing intestinal damage and prevent further damage.

Improvement begins within days of starting the diet, according to NDDIC.

The small intestine usually heals in three to six months in children but may take several years in adults.

Eating a gluten-free diet also helps lessen the symptoms of people with autism and schizophrenia, according to Mark.

"I don't have celiac disease and I wouldn't consume gluten. It's poisonous to your whole body," said Mark. "I have seen patients that have had hives for 20 years that go away after they stop eating gluten."

Symptoms of celiac disease vary from person to person but can include abdominal bloating and pain; chronic diarrhea, vomiting, constipation and weight loss. These symptoms are more common in infants and children, according to the NDDIC.

Some symptoms common in adults include unexplained iron-deficiency anemia; fat-igue; joint or bone pain; arthritis; seizures; missed menstrual periods, infertility or recurrent miscarriage.

Celiac disease is diagnosed through blood tests and intestinal biopsies.

Fifteen to 25 percent of the people who have the disease also have dermatitis herpetiforms, an intensely itchy blistering skin rash that usually occurs on the elbows, knees and buttocks, according to NDDIC.

Celiac disease affects one in 133 people, according to Sutphin. Among people who have a first-degree relative -- a parent, sibling or child -- diagnosed with celiac disease, as many as one in 22 people may have the disease, according to NDDIC. However, people can still have the disease even though no one in their family has it.

Other times, the gene exists but the body is able to prevent the disease from manifesting, according to Mark.

Contact Elaine Blaisdell at eblaisdell@times-news.com.

©2011 the Cumberland Times News (Cumberland, Md.)

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Be Vitamin B12 Aware

Posted Nov 7, 2011

Vitamin B12 is important, and many people over 50 have a deficiency of this essential nutrient. There are a number of reasons for it. The most serious is pernicious anemia, caused by the lack of a protein that’s required for the body to absorb B12. The most common reason is ‘Atrophic gastritis,’ a condition where the lining of the stomach gets thinner as we age. It’s estimated that atrophic gastritis affects as many as one third of people over 50. Heavy use of anti-acid drugs can also affect the absorption of B12, as can gastric bypass surgery.

Symptoms of a mild deficiency may include irritability, problems with concentration, dizziness and fatigue, diarrhea, weight loss and easy bruising; though many mild cases have no symptoms at all. But as the deficiency gets more severe, it causes more serious symptoms. They include depression, confusion and memory loss; as well as problems with balance and tingling or numbness in fingers and toes. If the deficiency isn’t diagnosed and cured by B12 supplements, it can progress to actual dementia.

Because the symptoms can be so severe, some physicians miss the diagnosis of a simple vitamin deficiency that’s easily cured by a shot or a pill of the nutrient, taken with the total B factor. But it’s essential to get a quick and accurate diagnosis, because some recent studies are showing that a B12 deficiency may be connected with the onset and cause of Alzheimer’s disease. Numerous other studies show that an absence of this nutrient is also involved with the onset of clinical depression; a common problem in boomers and seniors.

Those over 50 who are vegetarians are at particular risk, because B12 is found mostly in animal-based foods such as meat, milk, eggs, poultry and fish. Those who eat none of these foods should supplement their diets with the full B factor in pill form.

If there’s any suspicion that you or someone you know may be suffering from a lack of B12, an easy and inexpensive blood test can determine the amount of this nutrient in the body. It’s important to know that even a very small deficiency can cause problems; some of which are even more serious than mental disturbances. B12 helps keep the amount of the amino acid homocysteine in balance, a function that may help lower the risk of heart disease.

Since a B12 deficiency is so much more common that most people realize, it’s a good idea to take a proactive stance by consuming a daily supplement of the full B complex, which will include B12. The B complex is totally interactive; all factors need to be included for any part of the vitamin to be absorbed.

But for those over 50, a blood screening in addition to supplementation is an ideal way to determine if you have enough vitamin B12 to keep your brain in good shape.

Wina Sturgeon is an active boomer based in Salt Lake City who mountain bikes, skates on both ice blades and wheels, lifts weights and runs to stay in shape.

© 2011, Adventure Sports Weekly (adventuresportsweekly.com)

Vitamin B12 is important, and many people over 50 have a deficiency of this essential nutrient. There are a number of reasons for it. The most serious is pernicious anemia, caused by the lack of a protein that's required for the body to absorb B12. The most common reason is 'Atrophic gastritis,' a condition where the lining of the stomach gets thinner as we age. It's estimated that atrophic gastritis affects as many as one third of people over 50. Heavy use of anti-acid drugs can also affect the absorption of B12, as can gastric bypass surgery.

Symptoms of a mild deficiency may include irritability, problems with concentration, dizziness and fatigue, diarrhea, weight loss and easy bruising; though many mild cases have no symptoms at all. But as the deficiency gets more severe, it causes more serious symptoms. They include depression, confusion and memory loss; as well as problems with balance and tingling or numbness in fingers and toes. If the deficiency isn't diagnosed and cured by B12 supplements, it can progress to actual dementia.

Because the symptoms can be so severe, some physicians miss the diagnosis of a simple vitamin deficiency that's easily cured by a shot or a pill of the nutrient, taken with the total B factor. But it's essential to get a quick and accurate diagnosis, because some recent studies are showing that a B12 deficiency may be connected with the onset and cause of Alzheimer's disease. Numerous other studies show that an absence of this nutrient is also involved with the onset of clinical depression; a common problem in boomers and seniors.

Those over 50 who are vegetarians are at particular risk, because B12 is found mostly in animal-based foods such as meat, milk, eggs, poultry and fish. Those who eat none of these foods should supplement their diets with the full B factor in pill form.

If there's any suspicion that you or someone you know may be suffering from a lack of B12, an easy and inexpensive blood test can determine the amount of this nutrient in the body. It's important to know that even a very small deficiency can cause problems; some of which are even more serious than mental disturbances. B12 helps keep the amount of the amino acid homocysteine in balance, a function that may help lower the risk of heart disease.

Since a B12 deficiency is so much more common that most people realize, it's a good idea to take a proactive stance by consuming a daily supplement of the full B complex, which will include B12. The B complex is totally interactive; all factors need to be included for any part of the vitamin to be absorbed.

But for those over 50, a blood screening in addition to supplementation is an ideal way to determine if you have enough vitamin B12 to keep your brain in good shape.

Wina Sturgeon is an active boomer based in Salt Lake City who mountain bikes, skates on both ice blades and wheels, lifts weights and runs to stay in shape.

© 2011, Adventure Sports Weekly (adventuresportsweekly.com)

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Pick Your Produce

Posted October 22, 2011

Romaine and spinach often sit side by side at the salad bar, but one stands taller.

“The darker the green, the more nutrient-dense it’s going to be,” said Heather Mangieri, a spokeswoman for the American Dietetic Association.

Spinach contains more vitamin C (an antioxidant), iron (helps prevent anemia), magnesium (can help protect against heart disease) and vitamin K (good for bones and blood). Spinach also packs calcium, but there’s a catch.

“We don’t think of spinach being a great source of calcium because it’s high in oxalates, which bind with calcium and make it unavailable,” Mangieri said. Boiling spinach releases the oxalates and many nutrients into the cooking water.

Romaine is on the milder end of the greens spectrum but still nutritious. “It’s definitely a step up from iceberg lettuce,” Mangieri said.

If you’re bored even with spinach, advance to bitter arugula or try trendy kale. Drizzle it with olive oil, dash with pepper and bake, said Mangieri. And forget that it once was relegated to lining the salad bar.

To compare nutritional value of foods, see the USDA’s National Nutrient Database at nal.usda.gov/fnic/foodcomp/search.

To see more of the Chicago Tribune, or to subscribe to the newspaper, go to http://www.chicagotribune.com.

Copyright © 2011, Chicago Tribune

Romaine and spinach often sit side by side at the salad bar, but one stands taller.

"The darker the green, the more nutrient-dense it's going to be," said Heather Mangieri, a spokeswoman for the American Dietetic Association.

Spinach contains more vitamin C (an antioxidant), iron (helps prevent anemia), magnesium (can help protect against heart disease) and vitamin K (good for bones and blood). Spinach also packs calcium, but there's a catch.

"We don't think of spinach being a great source of calcium because it's high in oxalates, which bind with calcium and make it unavailable," Mangieri said. Boiling spinach releases the oxalates and many nutrients into the cooking water.

Romaine is on the milder end of the greens spectrum but still nutritious. "It's definitely a step up from iceberg lettuce," Mangieri said.

If you're bored even with spinach, advance to bitter arugula or try trendy kale. Drizzle it with olive oil, dash with pepper and bake, said Mangieri. And forget that it once was relegated to lining the salad bar.

To compare nutritional value of foods, see the USDA's National Nutrient Database at nal.usda.gov/fnic/foodcomp/search.

To see more of the Chicago Tribune, or to subscribe to the newspaper, go to http://www.chicagotribune.com.



Copyright © 2011, Chicago Tribune

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More Gluten Free Menu Options

Posted Sept 16, 2011

Eating at a restaurant can be a challenge for anyone on a restricted diet.

But when eating the wrong food can make you sick, eating out can be become downright scary.

Getting sick from food is a real possibility for the growing number of Americans who have celiac disease.

People with celiac disease have an intolerance to gluten, a protein found in wheat, barley and rye. It is considered the most under-diagnosed disease in the country, and it may affect one out of every 133 Americans, according to the Gluten Intolerance Group of North America, a national support group.

In addition, many more people have found that they have a sensitivity to wheat and/or gluten. Others have chosen not to eat wheat or gluten for various reasons. Some say they feel better without it; others think it helps with weight loss.

In the past, eating out has been difficult for anyone on a gluten-free diet. In carb-crazy, wheat-loving America, sometimes a salad might be the only thing on the menu that doesn’t use flour, bread, pasta or something else with gluten. And many times that salad comes with croutons.

Thomas Manning, a Forsyth County native who lives in North Raleigh, remembers eating out six years ago after he first found out he had celiac disease. Often, after he explained his situation, restaurant employees would become scared to serve him, worried that any mistake might make him sick. And many times when they did serve him, they’d offer nothing beyond a plain grilled chicken breast and a salad. “I got so tired of chicken breast and salad,” he said.

But now restaurants are starting to listen to — and welcome — the increasing numbers of diners who avoid wheat and gluten.

“There are a lot more restaurants that offer gluten-free options,” said Debbie Fisher of Clemmons, who also has celiac disease. “And the gluten-free menus have a lot more items on them.”

When Martha Russell learned she had celiac disease in 2003, “some people didn’t even know what gluten is,” she said. “Chefs are so much more aware of this now. And they love the challenge of creating something different for you.”

The Gluten Intolerance Group (www.gluten.net) has enrolled 1,620 restaurants in the country in its Gluten-Free Restaurant Awareness Program. In Winston-Salem, several restaurants now offer gluten-free options.

Extensive gluten-free menus are offered at such chains as Bonefish Grill, Carrabba’s Italian Grill, Firebirds Wood Fired Grill, Outback Steak House and Village Tavern, and at such independent restaurants as New Town Bistro and River Birch Lodge.

Jason’s Deli, a chain based in Texas with a location on Hanes Mall Boulevard, offers sandwiches on gluten-free bread. Mellow Mushroom and Brixx Wood Fired Pizza both offer gluten-free pizza.

Serving gluten-free meals is not as simple as removing or replacing the bread or pasta.

The gluten from wheat, barley and rye show up — or rather hide — in many ingredients.

“I’m very skeptical about any sauce or salad dressing,” said Fran Fox, because those often use flour for thickening. Fox, who has been gluten-free for 25 years, said it does require asking a lot of questions at restaurants.

Another hidden ingredient is soy sauce, which usually contains wheat. Other ingredients, such as malted barley, lurk in many processed foods.

Russell and others tend to stay away from Chinese and other Asian restaurants that use soy sauce. They often feel more comfortable in Mexican and Indian restaurants that do not rely heavily on wheat.

But it’s not just the ingredients. Cross-contamination poses a danger, too. Vegetables chopped on the same cutting board as a loaf of bread can contaminate someone’s salad and make them sick.

Similarly, the cook who makes a salad with croutons and then makes a gluten-free salad can contaminate the gluten-free salad.

At New Town Bistro, chef Donny Smith pulls out a clean cutting board and clean utensils when someone orders a gluten-free item.

“It’s not the best thing at 7 p.m. on a Saturday night, but there’s no other way around it,” Smith said. “It just becomes part of our job. We want to make sure people didn’t use tongs to grab bread out of the oven, then use it to grab a gluten-free entree.”

At Mellow Mushroom, general manager Margaret Waters said the staff changes aprons, washes hands and moves to a separate work area after receiving an order for a gluten-free pizza.

“We even have a different cart of ingredients — toppings, the sauce, the cheese — that we keep separate from everything else,” she said. And the pizza is put on a special rack so it does not touch the same oven surfaces that the regular pizzas touch.

When someone orders a gluten-free sandwich at Jason’s Deli, “only the managers are allowed to make it,” said supervisor Nancy Hernandez. “We make it in the back of the restaurant. We get all of the ingredients fresh from the back. We don’t use anything from the line” that might have come in contact with regular bread.

A plain piece of meat might seem like a safe choice, but not if it’s grilled on the same spot as grilled bread. Chef Travis Myers of River Birch Lodge sautes meats on his gluten-free menu in clean pans instead of grilling them.

Myers cooks all of his breaded and other gluten foods in one deep fryer, dedicating a second fryer to gluten-free items. “We can do french fries and (homemade potato) chips and not worry about cross-contamination,” he said.

Myers has a gluten-free menu of five appetizers, five salads, four sandwiches, eight entrees and three desserts.

In some cases, he has made an item gluten-free simply by removing the gluten ingredient. For instance, the seared tuna appetizer comes with pickled ginger but without the usual ginger sauce, which is made with soy sauce.

“Once we dove into the nuts and bolts of it, it was easy to make things gluten-free, because we make most things in-house,” Myers said. >

River Birch has offered a gluten-free menu longer than most — about six years. “Our lawyer’s family is gluten-intolerant, so that’s how we learned about it,” he said.

“Word of mouth has really helped us. Now I’d say one out of every five tables we’re getting a gluten-free order. A lot of times we’ll have a whole party of gluten-free.”

That was the case last Thursday when about a dozen members of the local Gluten Intolerance Group ate lunch at River Birch. Myers sent out a continuous supply of gluten-free items to sample.

Some are naturally gluten-free, such as the homemade potato chips with dipping sauces, and the cedar-plank salmon. Some require simple substitutions from the regular menu, like serving the goat cheese fresh instead of breaded and pan-fried in the chevre salad.

Other items include pulled pork, Thai chicken salad and gluten-free pasta in a white-wine sauce.

“Getting the staff up-to-date has been the key to this,” Myers said. “We train and retrain, telling them how serious it can be if a gluten-intolerant person got a big, old crouton on their salad.”

But the more gluten-free orders he gets, the better he and his staff can do. “I think once you get over the initial crunch, and you really grasp things, it’s easier.” mhastings@wsjournal.com

About celiac disease

Celiac disease is most often referred to as gluten intolerance. For someone who has the disease, consumption of gluten — a protein found in wheat, barley and rye — causes damage to the small intestine.

The disease has many symptoms, and different people exhibit different symptoms and different sensitivities to gluten. Possible symptoms include diarrhea, bloating, weight loss, weakness, anemia, chronic fatigue, muscle cramps, migraine headaches, nerve problems and bone pain.

Because of the variety of symptoms, celiac disease is often confused with other diseases, and it often goes undiagnosed. But a panel of blood tests has been developed to screen for the disease.

Celiac disease is a chronic, inherited disease. A cure does not exist. Treatment consists of eating a diet free of all gluten. Because the disease causes nutrients to pass through the small intestine instead of being absorbed, the disease can lead to malnutrition if left untreated.

Gluten-free menus

Here are some area restaurants that offer gluten-free menus. The menus also are posted on their websites:

* Bonefish Grill, www.bonefishgrill.com

* Brixx Wood Fired Pizza, www.brixxpizza.com

* Carrabba’s Italian Grill, www.carrabbas.com

* Firebirds Wood Fired Grill, www.firebirdsrestaurants.com

* Jason’s Deli, www.jasonsdeli.com

* Mellow Mushroom, www.mellowmushroom.com

* New Town Bistro, www.newtownbistro.com

* Olive Garden, www.olivegarden.com

* Outback Steak House, www.outback.com

* River Birch Lodge, www.riverbirchlodge.com

* Village Tavern, www.villagetavern.com

Note that these menus typically contain warnings or qualifiers that say the restaurants do not assume responsibility for the accuracy of the menus, which typically have been prepared by an outside dietitian or other person.

Many gluten-free diners say that a gluten-free menu is no guarantee of a gluten-free meal. Several local diners mentioned instances when their “gluten-free meal” arrived with wheat croutons in the salad or wheat bread on the plate.

Adequate training and knowledge can be especially difficult in large restaurants or those in which employee turnover is high.

In short, a gluten-free meal is dependent on the understanding and communication of all parties involved, including the wait staff, kitchen staff and diners.

Grace Johnston, team leader of the local Gluten Intolerance Group, makes these suggestions for eating out on a gluten-free diet:

* Go when the restaurant isn’t busy and has time to accommodate special requests.

* Talk directly with the head chef or a manager about the need for a gluten-free meal.

* Ask lots of questions about ingredients and preparation.

Michael Hastings

©2011 Winston-Salem Journal (Winston Salem, N.C.)

Eating at a restaurant can be a challenge for anyone on a restricted diet.

But when eating the wrong food can make you sick, eating out can be become downright scary.

Getting sick from food is a real possibility for the growing number of Americans who have celiac disease.

People with celiac disease have an intolerance to gluten, a protein found in wheat, barley and rye. It is considered the most under-diagnosed disease in the country, and it may affect one out of every 133 Americans, according to the Gluten Intolerance Group of North America, a national support group.

In addition, many more people have found that they have a sensitivity to wheat and/or gluten. Others have chosen not to eat wheat or gluten for various reasons. Some say they feel better without it; others think it helps with weight loss.

In the past, eating out has been difficult for anyone on a gluten-free diet. In carb-crazy, wheat-loving America, sometimes a salad might be the only thing on the menu that doesn't use flour, bread, pasta or something else with gluten. And many times that salad comes with croutons.

Thomas Manning, a Forsyth County native who lives in North Raleigh, remembers eating out six years ago after he first found out he had celiac disease. Often, after he explained his situation, restaurant employees would become scared to serve him, worried that any mistake might make him sick. And many times when they did serve him, they'd offer nothing beyond a plain grilled chicken breast and a salad. "I got so tired of chicken breast and salad," he said.

But now restaurants are starting to listen to -- and welcome -- the increasing numbers of diners who avoid wheat and gluten.

"There are a lot more restaurants that offer gluten-free options," said Debbie Fisher of Clemmons, who also has celiac disease. "And the gluten-free menus have a lot more items on them."

When Martha Russell learned she had celiac disease in 2003, "some people didn't even know what gluten is," she said. "Chefs are so much more aware of this now. And they love the challenge of creating something different for you."

The Gluten Intolerance Group (www.gluten.net) has enrolled 1,620 restaurants in the country in its Gluten-Free Restaurant Awareness Program. In Winston-Salem, several restaurants now offer gluten-free options.

Extensive gluten-free menus are offered at such chains as Bonefish Grill, Carrabba's Italian Grill, Firebirds Wood Fired Grill, Outback Steak House and Village Tavern, and at such independent restaurants as New Town Bistro and River Birch Lodge.

Jason's Deli, a chain based in Texas with a location on Hanes Mall Boulevard, offers sandwiches on gluten-free bread. Mellow Mushroom and Brixx Wood Fired Pizza both offer gluten-free pizza.

Serving gluten-free meals is not as simple as removing or replacing the bread or pasta.

The gluten from wheat, barley and rye show up -- or rather hide -- in many ingredients.

"I'm very skeptical about any sauce or salad dressing," said Fran Fox, because those often use flour for thickening. Fox, who has been gluten-free for 25 years, said it does require asking a lot of questions at restaurants.

Another hidden ingredient is soy sauce, which usually contains wheat. Other ingredients, such as malted barley, lurk in many processed foods.

Russell and others tend to stay away from Chinese and other Asian restaurants that use soy sauce. They often feel more comfortable in Mexican and Indian restaurants that do not rely heavily on wheat.

But it's not just the ingredients. Cross-contamination poses a danger, too. Vegetables chopped on the same cutting board as a loaf of bread can contaminate someone's salad and make them sick.

Similarly, the cook who makes a salad with croutons and then makes a gluten-free salad can contaminate the gluten-free salad.

At New Town Bistro, chef Donny Smith pulls out a clean cutting board and clean utensils when someone orders a gluten-free item.

"It's not the best thing at 7 p.m. on a Saturday night, but there's no other way around it," Smith said. "It just becomes part of our job. We want to make sure people didn't use tongs to grab bread out of the oven, then use it to grab a gluten-free entree."

At Mellow Mushroom, general manager Margaret Waters said the staff changes aprons, washes hands and moves to a separate work area after receiving an order for a gluten-free pizza.

"We even have a different cart of ingredients -- toppings, the sauce, the cheese -- that we keep separate from everything else," she said. And the pizza is put on a special rack so it does not touch the same oven surfaces that the regular pizzas touch.

When someone orders a gluten-free sandwich at Jason's Deli, "only the managers are allowed to make it," said supervisor Nancy Hernandez. "We make it in the back of the restaurant. We get all of the ingredients fresh from the back. We don't use anything from the line" that might have come in contact with regular bread.

A plain piece of meat might seem like a safe choice, but not if it's grilled on the same spot as grilled bread. Chef Travis Myers of River Birch Lodge sautes meats on his gluten-free menu in clean pans instead of grilling them.

Myers cooks all of his breaded and other gluten foods in one deep fryer, dedicating a second fryer to gluten-free items. "We can do french fries and (homemade potato) chips and not worry about cross-contamination," he said.

Myers has a gluten-free menu of five appetizers, five salads, four sandwiches, eight entrees and three desserts.

In some cases, he has made an item gluten-free simply by removing the gluten ingredient. For instance, the seared tuna appetizer comes with pickled ginger but without the usual ginger sauce, which is made with soy sauce.

"Once we dove into the nuts and bolts of it, it was easy to make things gluten-free, because we make most things in-house," Myers said. >

River Birch has offered a gluten-free menu longer than most -- about six years. "Our lawyer's family is gluten-intolerant, so that's how we learned about it," he said.

"Word of mouth has really helped us. Now I'd say one out of every five tables we're getting a gluten-free order. A lot of times we'll have a whole party of gluten-free."

That was the case last Thursday when about a dozen members of the local Gluten Intolerance Group ate lunch at River Birch. Myers sent out a continuous supply of gluten-free items to sample.

Some are naturally gluten-free, such as the homemade potato chips with dipping sauces, and the cedar-plank salmon. Some require simple substitutions from the regular menu, like serving the goat cheese fresh instead of breaded and pan-fried in the chevre salad.

Other items include pulled pork, Thai chicken salad and gluten-free pasta in a white-wine sauce.

"Getting the staff up-to-date has been the key to this," Myers said. "We train and retrain, telling them how serious it can be if a gluten-intolerant person got a big, old crouton on their salad."

But the more gluten-free orders he gets, the better he and his staff can do. "I think once you get over the initial crunch, and you really grasp things, it's easier." mhastings@wsjournal.com

About celiac disease

Celiac disease is most often referred to as gluten intolerance. For someone who has the disease, consumption of gluten -- a protein found in wheat, barley and rye -- causes damage to the small intestine.

The disease has many symptoms, and different people exhibit different symptoms and different sensitivities to gluten. Possible symptoms include diarrhea, bloating, weight loss, weakness, anemia, chronic fatigue, muscle cramps, migraine headaches, nerve problems and bone pain.

Because of the variety of symptoms, celiac disease is often confused with other diseases, and it often goes undiagnosed. But a panel of blood tests has been developed to screen for the disease.

Celiac disease is a chronic, inherited disease. A cure does not exist. Treatment consists of eating a diet free of all gluten. Because the disease causes nutrients to pass through the small intestine instead of being absorbed, the disease can lead to malnutrition if left untreated.

Gluten-free menus

Here are some area restaurants that offer gluten-free menus. The menus also are posted on their websites:

* Bonefish Grill, www.bonefishgrill.com

* Brixx Wood Fired Pizza, www.brixxpizza.com

* Carrabba's Italian Grill, www.carrabbas.com

* Firebirds Wood Fired Grill, www.firebirdsrestaurants.com

* Jason's Deli, www.jasonsdeli.com

* Mellow Mushroom, www.mellowmushroom.com

* New Town Bistro, www.newtownbistro.com

* Olive Garden, www.olivegarden.com

* Outback Steak House, www.outback.com

* River Birch Lodge, www.riverbirchlodge.com

* Village Tavern, www.villagetavern.com

Note that these menus typically contain warnings or qualifiers that say the restaurants do not assume responsibility for the accuracy of the menus, which typically have been prepared by an outside dietitian or other person.

Many gluten-free diners say that a gluten-free menu is no guarantee of a gluten-free meal. Several local diners mentioned instances when their "gluten-free meal" arrived with wheat croutons in the salad or wheat bread on the plate.

Adequate training and knowledge can be especially difficult in large restaurants or those in which employee turnover is high.

In short, a gluten-free meal is dependent on the understanding and communication of all parties involved, including the wait staff, kitchen staff and diners.

Grace Johnston, team leader of the local Gluten Intolerance Group, makes these suggestions for eating out on a gluten-free diet:

* Go when the restaurant isn't busy and has time to accommodate special requests.

* Talk directly with the head chef or a manager about the need for a gluten-free meal.

* Ask lots of questions about ingredients and preparation.

Michael Hastings

©2011 Winston-Salem Journal (Winston Salem, N.C.)

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Medication-Induced Nutrient Deficiencies

Posted Sept 14, 2011

Dietary deficiencies are a significant problem in the United States, especially when fruits, vegetables, whole grains and other healthy foods are eaten in limited quantities. A study published in 2005 showed that many Americans were not meeting the U.S. Recommended Dietary Allowances for a number of nutrients: 73 percent of people were not getting enough zinc in their diets, 65 percent were deficient in calcium intake, 62 percent were low in magnesium, 56 percent in vitamin A and 54 percent in vitamin B6, to name a few.

Persistent nutrient deficiencies can increase the risk of chronic illness, including heart disease, high blood pressure, diabetes, osteoporosis, anemia and neurologic symptoms.

A new concern in health care is that, on top of already marginal nutrient intake for some people, nutrient depletion is worsened by some of the common medications taken by many Americans.

Medication-induced nutrient depletion can occur though several mechanisms; for example, some drugs may interfere with the absorption of nutrients, while others may lead to increased excretion. Some of these effects can be significant, especially when the medications are taken for long periods.

Below is a sampling of some of the most widely used medications and the nutrient losses that they induce:

-Stomach acid medications, including proton pump inhibitors like Prilosec, H2 blockers such as Zantac, and general antacids, all block the production of stomach acid. While this can help to soothe your heartburn in the short term, the long-term suppression of stomach acid leads to reduced absorption of many nutrients, including calcium, magnesium, zinc, iron, vitamins B12 and C, and beta carotene.

Magnesium deficiency in particular is troubling because it can lead to potentially life-threatening heart arrhythmias. Magnesium deficiency can contribute to anxiety, restless leg syndrome, insomnia and muscle spasm.

In March, the FDA published a safety announcement on the risk of magnesium deficiency in anyone taking proton pump inhibitors for more than a year. And while some people may be protected by taking a daily magnesium supplement, studies suggest that about 25 percent of people who take PPIs are unable to normalize their blood magnesium level with a supplement – they have to stop the drug in order to return their blood magnesium levels to normal. Long-term reduction in calcium absorption from PPIs also can affect your bone health and increase your risk of osteoporosis.

-Metformin (also known as Glucophage) is a widely used drug for diabetes that causes the depletion of several nutrients, including vitamin B12, folic acid and coenzyme Q10. Up to 30 percent of people taking metformin will develop B12 deficiency, whose symptoms include anemia and neuropathy. Anyone taking metformin on a continuing basis should have B12 blood levels checked periodically. B12 supplements will generally correct any deficiency caused by this drug.

-Antibiotics, while very useful for killing off harmful bacteria in the body, also kill off healthy bacteria in the gut. These healthy bugs are there for a reason – they help produce B vitamins and vitamin K, and they also affect the function of the immune system.

Disruption of this healthy flora is an active area of research now, and has been tied to multiple medical conditions including cancer, depression and autoimmune disorders. A reduction in healthy intestinal flora can also lead to the overgrowth of more dangerous bacteria in the gut, including E. coli and C. difficile, leading to infectious gastroenteritis. Probiotic supplements may help offset damage to the gut caused by antibiotics.

-Statin drugs like Lipitor and Zocor are excellent at lowering your cholesterol, but they also lower blood levels of coenzyme Q10, especially when high doses are used. Coenzyme Q10 is a fat-soluble antioxidant found in most tissues of the body, and depletion of this compound by statin drugs may lead to muscle pain. From some people taking statins, coenzyme Q10 supplements will help to reduce this pain.

-Diuretics, also known as water pills, cause multiple nutrient losses in the urine. All diuretics cause urinary loss of potassium, magnesium and vitamin B1 (thiamine), which can cause or aggravate heart disease. Certain diuretics also cause loss of calcium, vitamin B6, folic acid and vitamin C. People who take diuretics need to be monitored for nutrient losses and may need to take supplements to make up for these losses.

The medications discussed above are primarily used in people with diabetes, heart disease, high blood pressure and chronic heartburn – conditions that are usually preventable – so staying healthy by eating a nutrient-rich diet, getting regular exercise and maintaining your weight can help you to avoid the need for medication in the first place.

However, if you are one of the many Americans who find yourself needing these meds on a long-term basis, talk with your doctor about monitoring your nutrient levels. And of course, never stop a medication that your doctor has prescribed without talking with him or her first.

Drs. Kay Judge and Maxine Barish-Wreden are medical directors of Sutter Downtown Integrative Medicine program in Sacramento, Calif. Have a question related to alternative medicine? Email adrenaline@sacbee.com.

Dietary deficiencies are a significant problem in the United States, especially when fruits, vegetables, whole grains and other healthy foods are eaten in limited quantities. A study published in 2005 showed that many Americans were not meeting the U.S. Recommended Dietary Allowances for a number of nutrients: 73 percent of people were not getting enough zinc in their diets, 65 percent were deficient in calcium intake, 62 percent were low in magnesium, 56 percent in vitamin A and 54 percent in vitamin B6, to name a few.

Persistent nutrient deficiencies can increase the risk of chronic illness, including heart disease, high blood pressure, diabetes, osteoporosis, anemia and neurologic symptoms.

A new concern in health care is that, on top of already marginal nutrient intake for some people, nutrient depletion is worsened by some of the common medications taken by many Americans.

Medication-induced nutrient depletion can occur though several mechanisms; for example, some drugs may interfere with the absorption of nutrients, while others may lead to increased excretion. Some of these effects can be significant, especially when the medications are taken for long periods.

Below is a sampling of some of the most widely used medications and the nutrient losses that they induce:

-Stomach acid medications, including proton pump inhibitors like Prilosec, H2 blockers such as Zantac, and general antacids, all block the production of stomach acid. While this can help to soothe your heartburn in the short term, the long-term suppression of stomach acid leads to reduced absorption of many nutrients, including calcium, magnesium, zinc, iron, vitamins B12 and C, and beta carotene.

Magnesium deficiency in particular is troubling because it can lead to potentially life-threatening heart arrhythmias. Magnesium deficiency can contribute to anxiety, restless leg syndrome, insomnia and muscle spasm.

In March, the FDA published a safety announcement on the risk of magnesium deficiency in anyone taking proton pump inhibitors for more than a year. And while some people may be protected by taking a daily magnesium supplement, studies suggest that about 25 percent of people who take PPIs are unable to normalize their blood magnesium level with a supplement - they have to stop the drug in order to return their blood magnesium levels to normal. Long-term reduction in calcium absorption from PPIs also can affect your bone health and increase your risk of osteoporosis.

-Metformin (also known as Glucophage) is a widely used drug for diabetes that causes the depletion of several nutrients, including vitamin B12, folic acid and coenzyme Q10. Up to 30 percent of people taking metformin will develop B12 deficiency, whose symptoms include anemia and neuropathy. Anyone taking metformin on a continuing basis should have B12 blood levels checked periodically. B12 supplements will generally correct any deficiency caused by this drug.

-Antibiotics, while very useful for killing off harmful bacteria in the body, also kill off healthy bacteria in the gut. These healthy bugs are there for a reason - they help produce B vitamins and vitamin K, and they also affect the function of the immune system.

Disruption of this healthy flora is an active area of research now, and has been tied to multiple medical conditions including cancer, depression and autoimmune disorders. A reduction in healthy intestinal flora can also lead to the overgrowth of more dangerous bacteria in the gut, including E. coli and C. difficile, leading to infectious gastroenteritis. Probiotic supplements may help offset damage to the gut caused by antibiotics.

-Statin drugs like Lipitor and Zocor are excellent at lowering your cholesterol, but they also lower blood levels of coenzyme Q10, especially when high doses are used. Coenzyme Q10 is a fat-soluble antioxidant found in most tissues of the body, and depletion of this compound by statin drugs may lead to muscle pain. From some people taking statins, coenzyme Q10 supplements will help to reduce this pain.

-Diuretics, also known as water pills, cause multiple nutrient losses in the urine. All diuretics cause urinary loss of potassium, magnesium and vitamin B1 (thiamine), which can cause or aggravate heart disease. Certain diuretics also cause loss of calcium, vitamin B6, folic acid and vitamin C. People who take diuretics need to be monitored for nutrient losses and may need to take supplements to make up for these losses.

The medications discussed above are primarily used in people with diabetes, heart disease, high blood pressure and chronic heartburn - conditions that are usually preventable - so staying healthy by eating a nutrient-rich diet, getting regular exercise and maintaining your weight can help you to avoid the need for medication in the first place.

However, if you are one of the many Americans who find yourself needing these meds on a long-term basis, talk with your doctor about monitoring your nutrient levels. And of course, never stop a medication that your doctor has prescribed without talking with him or her first.

Drs. Kay Judge and Maxine Barish-Wreden are medical directors of Sutter Downtown Integrative Medicine program in Sacramento, Calif. Have a question related to alternative medicine? Email adrenaline@sacbee.com.

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Folate Facts

Posted Mar 9, 2011

This just in: Folate, that enriching B vitamin, can help slow age-related hearing loss. Eh – what’s that? Folate can help … you get the idea. Take our quiz about folate’s benefits.

1 According to a study in the Journal of Nutrition, subjects over age 50 who had low folate levels were how much more likely to experience hearing loss?

a) 39 percent

b) 29 percent

c) 19 percent

2 Researchers have theorized that elevated levels of homocysteine, which folate has been shown to lower in the body, cause the hearing loss. What is homocysteine?

a) A peptide hormone released by the stomach that, among other things, activates hunger.

b) An amino acid in the blood that can cause vascular disease.

c) A mineral, absorbed by the tissues, that nourishes muscle mitochondria.

3 What is the daily value for folate?

a) 400 micrograms

b) 4,000 micrograms

c) 2 grams

4 Which food, at 45 percent of the daily value, is among the highest in folate?

a) asparagus, four spears

b) black-eyed peas, half a cup

c) beef liver, 3 ounces

5 Why is folate important for pregnant women?

a) It helps grow cells during rapid cell division.

b) It’s a nutrient needed to prevent anemia.

c) Both a and b.

ANSWERS: 1: a; 2: b; 3: a; 4: c; 5: c

-http://tuftshealthletter.com; Office of Dietary Supplements at the National Institutes of Health (http://ods.od.nih.gov)

This just in: Folate, that enriching B vitamin, can help slow age-related hearing loss. Eh - what's that? Folate can help ... you get the idea. Take our quiz about folate's benefits.

1 According to a study in the Journal of Nutrition, subjects over age 50 who had low folate levels were how much more likely to experience hearing loss?

a) 39 percent

b) 29 percent

c) 19 percent

2 Researchers have theorized that elevated levels of homocysteine, which folate has been shown to lower in the body, cause the hearing loss. What is homocysteine?

a) A peptide hormone released by the stomach that, among other things, activates hunger.

b) An amino acid in the blood that can cause vascular disease.

c) A mineral, absorbed by the tissues, that nourishes muscle mitochondria.

3 What is the daily value for folate?

a) 400 micrograms

b) 4,000 micrograms

c) 2 grams

4 Which food, at 45 percent of the daily value, is among the highest in folate?

a) asparagus, four spears

b) black-eyed peas, half a cup

c) beef liver, 3 ounces

5 Why is folate important for pregnant women?

a) It helps grow cells during rapid cell division.

b) It's a nutrient needed to prevent anemia.

c) Both a and b.

ANSWERS: 1: a; 2: b; 3: a; 4: c; 5: c

-http://tuftshealthletter.com; Office of Dietary Supplements at the National Institutes of Health (http://ods.od.nih.gov)

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Folate Facts

Posted Feb 3, 2011

This just in: Folate, that enriching B vitamin, can help slow age-related hearing loss. Eh what’s that? FOLATE CAN HELP … you get the idea. Take our quiz about folate and its benefits.

1. According to a study in the Journal of Nutrition, subjects older than 50 who had low folate levels were how much more likely to experience hearing loss?

a) 39 percent

b) 29 percent

c) 19 percent

2. Researchers have theorized that elevated levels of homocysteine, which folate has been shown to lower in the body, cause the hearing loss. What is homocysteine?

a) A peptide hormone released by the stomach that, among other things, activates hunger.

b) An amino acid in the blood that can cause vascular disease.

c) A mineral absorbed by the tissues that nourishes muscle mitochondria.

3. What is the daily value for folate?

a) 400 micrograms

b) 4,000 micrograms

c) 2 grams

4. Which food, at 45 percent of the daily value, is among the highest in folate?

a) asparagus, four spears

b) black-eyed peas, half a cup

c) beef liver, 3 ounces

5. Why is folate important for pregnant women?

a) It helps grow cells during rapid cell division

b) It’s a nutrient needed to prevent anemia

c) Both a and b.

ANSWERS: 1: a; 2: b; 3: a; 4: c; 5: c

Sources: tuftshealthletter.com; Office of Dietary Supplements at the National Institutes of Health (ods.od.nih.gov).

This just in: Folate, that enriching B vitamin, can help slow age-related hearing loss. Eh what's that? FOLATE CAN HELP ... you get the idea. Take our quiz about folate and its benefits.

1. According to a study in the Journal of Nutrition, subjects older than 50 who had low folate levels were how much more likely to experience hearing loss?

a) 39 percent

b) 29 percent

c) 19 percent

2. Researchers have theorized that elevated levels of homocysteine, which folate has been shown to lower in the body, cause the hearing loss. What is homocysteine?

a) A peptide hormone released by the stomach that, among other things, activates hunger.

b) An amino acid in the blood that can cause vascular disease.

c) A mineral absorbed by the tissues that nourishes muscle mitochondria.

3. What is the daily value for folate?

a) 400 micrograms

b) 4,000 micrograms

c) 2 grams

4. Which food, at 45 percent of the daily value, is among the highest in folate?

a) asparagus, four spears

b) black-eyed peas, half a cup

c) beef liver, 3 ounces

5. Why is folate important for pregnant women?

a) It helps grow cells during rapid cell division

b) It's a nutrient needed to prevent anemia

c) Both a and b.

ANSWERS: 1: a; 2: b; 3: a; 4: c; 5: c

Sources: tuftshealthletter.com; Office of Dietary Supplements at the National Institutes of Health (ods.od.nih.gov).

---

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Brighten Up Your Plate for Better Health

Posted Aug 14, 2010

Nutrition experts often suggest serving yourself a rainbow of colors as one way to make sure you eat a healthy diet, and local registered dietitian Shawn Craig likes the concept.

“The more color variety you have, the more likely you are to have a variety of different nutrients,” Craig said.

Fruits and vegetables can be found in nearly every color.

It’s harvest time, and whether the food comes from your own land, a farmers market, a fruit stand or the local grocer, you’ve got healthy options to chose from — try to select some yellows and oranges, greens, reds, purples and, for a little extra fiber, the whites.

Nutrients by color

Yellow and orange foods like squash, melons, peppers, tomatoes and carrots contain vitamin A, beta-carotene and vitamin C, Craig said.

“They’re useful for your vision and keeping your skin healthy,” she said.

Green foods like lettuce, broccoli, zucchini, green beans, Brussels sprouts and the leaves of beets are sources of B vitamins and folates “which helps prevent anemia and helps make your DNA,” Craig said. Folates prevent birth defects “and the beet greens are particularly high in folates and iron.”

Red foods include peppers, tomatoes, beets and apples (although apples contain different nutrients than the red vegetables listed). Red veggies contain high amounts of vitamin C and antioxidants. Antioxidants are good for cancer prevention, Craig said. Vitamin C is good for healthy gums and for wound healing.

Antioxidants “would be very high in the berries and also in beets, and then some fiber as well,” said Craig. So try purple foods like beets, grapes and black raspberries.

Variety

Other foods that can add variety to your diet include unusual foods like edible flowers (occasionally available at the Rochester farmers market) such as nasturtium and squash flowers. Such items are picked fresh, meaning their nutrient quantity remains high.

“They have a lot of fresh herbs available that can kind of give a new flavor twist to things you might already be preparing,” Craig said.

Simply get an herb like basil, thyme, cilantro or mint and check out the front of most general cookbooks, which have descriptions of the types of foods that go well with different herbs. You can chop them up and add them to a dish you might already be making, such as rice, pasta, soup or a casserole.

It’s good to add items to your diet, Craig said, because you are “increasing your variety and your interest in your meals and trying something new and, therefore, you’re gaining nutrition because of the variety that you’re adding.”

Get your kids involved

Some people find it tough to get their kids to eat vegetables. But don’t despair. Instead, keep encouraging them to try what they’re interested in.

“Research shows that kids need exposure to a new food approximately 10 times before they’re willing to try it,” Craig said.

Places you can get these foods include:

–Rochester downtown farmers market Saturday mornings

–Pine Island farmers market Friday afternoons

–Red Wing city hall daily, plus Saturday mornings

–Wednesday afternoons at Winona’s 2nd and Main Street location

Health reporter Jeff Hansel (285-7615) writes a blog Pulse on Health. Follow him on Twitter @JeffHansel

—–

To see more of the Post-Bulletin, or to subscribe to the newspaper, go to http://www.postbulletin.com.

Copyright © 2010, Post-Bulletin, Rochester, Minn.

Nutrition experts often suggest serving yourself a rainbow of colors as one way to make sure you eat a healthy diet, and local registered dietitian Shawn Craig likes the concept.

"The more color variety you have, the more likely you are to have a variety of different nutrients," Craig said.

Fruits and vegetables can be found in nearly every color.

It's harvest time, and whether the food comes from your own land, a farmers market, a fruit stand or the local grocer, you've got healthy options to chose from -- try to select some yellows and oranges, greens, reds, purples and, for a little extra fiber, the whites.

Nutrients by color

Yellow and orange foods like squash, melons, peppers, tomatoes and carrots contain vitamin A, beta-carotene and vitamin C, Craig said.

"They're useful for your vision and keeping your skin healthy," she said.

Green foods like lettuce, broccoli, zucchini, green beans, Brussels sprouts and the leaves of beets are sources of B vitamins and folates "which helps prevent anemia and helps make your DNA," Craig said. Folates prevent birth defects "and the beet greens are particularly high in folates and iron."

Red foods include peppers, tomatoes, beets and apples (although apples contain different nutrients than the red vegetables listed). Red veggies contain high amounts of vitamin C and antioxidants. Antioxidants are good for cancer prevention, Craig said. Vitamin C is good for healthy gums and for wound healing.

Antioxidants "would be very high in the berries and also in beets, and then some fiber as well," said Craig. So try purple foods like beets, grapes and black raspberries.

Variety

Other foods that can add variety to your diet include unusual foods like edible flowers (occasionally available at the Rochester farmers market) such as nasturtium and squash flowers. Such items are picked fresh, meaning their nutrient quantity remains high.

"They have a lot of fresh herbs available that can kind of give a new flavor twist to things you might already be preparing," Craig said.

Simply get an herb like basil, thyme, cilantro or mint and check out the front of most general cookbooks, which have descriptions of the types of foods that go well with different herbs. You can chop them up and add them to a dish you might already be making, such as rice, pasta, soup or a casserole.

It's good to add items to your diet, Craig said, because you are "increasing your variety and your interest in your meals and trying something new and, therefore, you're gaining nutrition because of the variety that you're adding."

Get your kids involved

Some people find it tough to get their kids to eat vegetables. But don't despair. Instead, keep encouraging them to try what they're interested in.

"Research shows that kids need exposure to a new food approximately 10 times before they're willing to try it," Craig said.

Places you can get these foods include:

--Rochester downtown farmers market Saturday mornings

--Pine Island farmers market Friday afternoons

--Red Wing city hall daily, plus Saturday mornings

--Wednesday afternoons at Winona's 2nd and Main Street location

Health reporter Jeff Hansel (285-7615) writes a blog Pulse on Health. Follow him on Twitter @JeffHansel

-----

To see more of the Post-Bulletin, or to subscribe to the newspaper, go to http://www.postbulletin.com.

Copyright © 2010, Post-Bulletin, Rochester, Minn.

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Child Supplement Considerations

Posted July 28, 2010

When my son was 4, I tried giving him nutritional supplements to make up for his appalling diet. I mixed fish oil into his orange juice. I let him eat candylike gummy multivitamins. And I stirred a chocolate powder containing 31 fruit and vegetable extracts into his milk.

It eased my worries, but experts disagree on whether supplements do any good.

“An appropriate diet should cover all needs,” said Dr. Steven Daniels, a member of the American Academy of Pediatrics’ committee on nutrition. Parents of picky eaters may be concerned, he said, but the worry “is often misplaced because kids are growing and developing normally.”

But how many kids eat an “appropriate” diet? Dr. Kathi Kemper, who chairs the holistic and integrative medicine department at the Wake Forest University School of Medicine, often recommends a multivitamin or fish oil which contains omega-3 fatty acids because “people have a funny idea what a healthy diet actually is,” she said. Surveys show that 99 percent of American children do not meet the recommended daily allowance for one or more essential nutrients, Kemper said.

If you do use supplements, look for children’s brands. Avoid large doses of anything; some nutrients, such as iron and vitamin A, can become toxic. Also note that supplements are not standardized and quality is not well-regulated by the Food and Drug Administration.

Here’s a guide to some of the more common supplements:

Multivitamins haven’t been shown to offer a tremendous benefit and aren’t recommended by the AAP, but they generally don’t hurt as long as they’re made for children and less than 100 percent of the daily recommended value. Gummy vitamins look and taste like candy; try brushing your child’s teeth afterward to avoid cavities, said registered dietitian Judith Dodd, a food and nutrition adviser and spokeswoman for the International Food Information Council Foundation.

Vitamin D: Studies have consistently shown that kids are not getting appropriate amounts of vitamin D in their diet, said the AAP’s Daniels. He added that it makes sense to take a multivitamin containing D. But scientists aren’t sure how much vitamin D children actually need. The AAP recommends 400 international units a day to prevent and treat rickets, a bone-softening disease. Dietary sources are limited but many foods are fortified with D. It’s also made by the body when the skin absorbs the sun’s rays.

Fish oil/omega-3′s: Kemper recommends fish oil for children who don’t eat fish two or three times a week. Children who have specific issues, such as high triglycerides (a type of fat in the blood that can raise the risk of heart disease), may need fish oil, said Daniels, but he doesn’t recommend it for the general population.

Liquid or powdered fruit and vegetable extracts: Whole fruits and vegetables are best. When choosing a supplement, much depends on how they are produced “because nutrients can be lost in the production process,” said registered dietitian Dee Sandquist, a spokeswoman for the American Dietetic Association. The biggest challenge, however, could be getting your picky eater to consume it in the first place.

Calcium: Children over age 3 are usually deficient in calcium: Only 15 percent of girls and 22 percent of boys meet the recommended intake levels, according to the federal dietary guidelines report. While a calcium supplement may be helpful, “milk has nine vitamins and minerals which provide an array of health benefits which a calcium supplement will not,” said Sandquist, who also recommends nondairy options (soy, almond, rice) or sources such as cereal and orange juice. But remember, it adds up: “We know about 500 milligrams is the right amount for absorption,” Dodd said. Anything more is excreted.

Iron: The AAP recommends 5 to 10 milligrams of iron for breast-fed babies. It should only be supplemented if needed for a medical condition, such as anemia, Sandquist said.

When my son was 4, I tried giving him nutritional supplements to make up for his appalling diet. I mixed fish oil into his orange juice. I let him eat candylike gummy multivitamins. And I stirred a chocolate powder containing 31 fruit and vegetable extracts into his milk.

It eased my worries, but experts disagree on whether supplements do any good.

"An appropriate diet should cover all needs," said Dr. Steven Daniels, a member of the American Academy of Pediatrics' committee on nutrition. Parents of picky eaters may be concerned, he said, but the worry "is often misplaced because kids are growing and developing normally."

But how many kids eat an "appropriate" diet? Dr. Kathi Kemper, who chairs the holistic and integrative medicine department at the Wake Forest University School of Medicine, often recommends a multivitamin or fish oil which contains omega-3 fatty acids because "people have a funny idea what a healthy diet actually is," she said. Surveys show that 99 percent of American children do not meet the recommended daily allowance for one or more essential nutrients, Kemper said.

If you do use supplements, look for children's brands. Avoid large doses of anything; some nutrients, such as iron and vitamin A, can become toxic. Also note that supplements are not standardized and quality is not well-regulated by the Food and Drug Administration.

Here's a guide to some of the more common supplements:

Multivitamins haven't been shown to offer a tremendous benefit and aren't recommended by the AAP, but they generally don't hurt as long as they're made for children and less than 100 percent of the daily recommended value. Gummy vitamins look and taste like candy; try brushing your child's teeth afterward to avoid cavities, said registered dietitian Judith Dodd, a food and nutrition adviser and spokeswoman for the International Food Information Council Foundation.

Vitamin D: Studies have consistently shown that kids are not getting appropriate amounts of vitamin D in their diet, said the AAP's Daniels. He added that it makes sense to take a multivitamin containing D. But scientists aren't sure how much vitamin D children actually need. The AAP recommends 400 international units a day to prevent and treat rickets, a bone-softening disease. Dietary sources are limited but many foods are fortified with D. It's also made by the body when the skin absorbs the sun's rays.

Fish oil/omega-3's: Kemper recommends fish oil for children who don't eat fish two or three times a week. Children who have specific issues, such as high triglycerides (a type of fat in the blood that can raise the risk of heart disease), may need fish oil, said Daniels, but he doesn't recommend it for the general population.

Liquid or powdered fruit and vegetable extracts: Whole fruits and vegetables are best. When choosing a supplement, much depends on how they are produced "because nutrients can be lost in the production process," said registered dietitian Dee Sandquist, a spokeswoman for the American Dietetic Association. The biggest challenge, however, could be getting your picky eater to consume it in the first place.

Calcium: Children over age 3 are usually deficient in calcium: Only 15 percent of girls and 22 percent of boys meet the recommended intake levels, according to the federal dietary guidelines report. While a calcium supplement may be helpful, "milk has nine vitamins and minerals which provide an array of health benefits which a calcium supplement will not," said Sandquist, who also recommends nondairy options (soy, almond, rice) or sources such as cereal and orange juice. But remember, it adds up: "We know about 500 milligrams is the right amount for absorption," Dodd said. Anything more is excreted.

Iron: The AAP recommends 5 to 10 milligrams of iron for breast-fed babies. It should only be supplemented if needed for a medical condition, such as anemia, Sandquist said.

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Blocking This Enzyme May Lead to New Diabetes Therapy

Posted April 23, 2010

Treating Type 2 diabetes, a major contributor to disease and death, may become easier if an unexpected discovery by a UC San Diego-led research team holds up.

The team found that mice stay fit, even on a high-fat diet, if they’re missing a protein that helps regulate metabolism, according to the study, led by UCSD biology professor Randall Johnson.

Mice genetically altered to lack the protein, an enzyme called FIH, burned off food faster than their normal counterparts, Johnson said. Their blood levels of HDL, or “bad” cholesterol, were lower than the control mice, which became obese and developed fatty livers.

“What’s exciting to my mind is that this research comes, to a significant extent, from left field,” said Johnson, who mainly researches cancer.

Researchers expected that deleting FIH would cause an increase in cancer in the mice, but that didn’t take place, Johnson said.

About 23.6 million Americans have Type 2 diabetes, or 7.8 percent of the population, according to the U.S. National Institutes of Health. Moreover, at least 57 million Americans are in danger of developing the disease. Diabetes is the seventh-leading cause of death.

FIH is involved in the body’s response to lower levels of oxygen. When the enzyme is lacking, the body assumes it’s in a low-oxygen environment. Mice lacking the enzyme develop a more rapid heart beat. They also breathe more deeply, which acts as exercise in burning up calories, Johnson said.

The genetically altered mice also display high sensitivity to insulin, which reduces blood sugar. Insulin resistance is a classic sign of Type 2 diabetes. In Type 1 diabetes, insulin production is insufficient.

FIH is easily inhibited by drugs, Johnson said.

“Some of these drugs, in animals, seem very benign,” Johnson said. “It’s quite possible it could be (tested) in humans rather quickly.”

Moreover, other types of FIH inhibitors are already in clinical trials for other diseases, including anemia. That could speed up testing those drugs for Type 2 diabetes.

Staff writer Bradley J. Fikes can be reached at 760-739-6641. Read his blogs at bizblogs.nctimes.com.

Date: April 16, 2010

To see more of the North County Times or to subscribe to the newspaper, go to http://www.nctimes.com.

Copyright © 2010, North County Times, Escondido, Calif.

Distributed by McClatchy-Tribune Information Services.

Treating Type 2 diabetes, a major contributor to disease and death, may become easier if an unexpected discovery by a UC San Diego-led research team holds up.

The team found that mice stay fit, even on a high-fat diet, if they're missing a protein that helps regulate metabolism, according to the study, led by UCSD biology professor Randall Johnson.

Mice genetically altered to lack the protein, an enzyme called FIH, burned off food faster than their normal counterparts, Johnson said. Their blood levels of HDL, or "bad" cholesterol, were lower than the control mice, which became obese and developed fatty livers.

"What's exciting to my mind is that this research comes, to a significant extent, from left field," said Johnson, who mainly researches cancer.

Researchers expected that deleting FIH would cause an increase in cancer in the mice, but that didn't take place, Johnson said.

About 23.6 million Americans have Type 2 diabetes, or 7.8 percent of the population, according to the U.S. National Institutes of Health. Moreover, at least 57 million Americans are in danger of developing the disease. Diabetes is the seventh-leading cause of death.

FIH is involved in the body's response to lower levels of oxygen. When the enzyme is lacking, the body assumes it's in a low-oxygen environment. Mice lacking the enzyme develop a more rapid heart beat. They also breathe more deeply, which acts as exercise in burning up calories, Johnson said.

The genetically altered mice also display high sensitivity to insulin, which reduces blood sugar. Insulin resistance is a classic sign of Type 2 diabetes. In Type 1 diabetes, insulin production is insufficient.

FIH is easily inhibited by drugs, Johnson said.

"Some of these drugs, in animals, seem very benign," Johnson said. "It's quite possible it could be (tested) in humans rather quickly."

Moreover, other types of FIH inhibitors are already in clinical trials for other diseases, including anemia. That could speed up testing those drugs for Type 2 diabetes.

Staff writer Bradley J. Fikes can be reached at 760-739-6641. Read his blogs at bizblogs.nctimes.com.

Date: April 16, 2010

To see more of the North County Times or to subscribe to the newspaper, go to http://www.nctimes.com.



Copyright © 2010, North County Times, Escondido, Calif.



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Yale Seeks Men for Testosterone Study

Posted Nov 10, 2009

The Yale School of Medicine is seeking older men for a major clinical study to test whether testosterone therapy can reduce health problems such as decreased physical and sexual function, impaired cognition and cardiovascular disease.

The Testosterone Trial at Yale University and 11 other sites across the nation will include 800 men age 65 and older with low testosterone levels, according to a press release.

“As men age, testosterone levels decline, which may lead to many conditions that are often attributed to age alone,” said Dr. Thomas M. Gill, professor of medicine at Yale and a specialist in the health of older adults. “The T-Trial is designed to provide definitive evidence on whether testosterone can reverse these conditions.

“If we find that it is a beneficial therapy, this would provide men and their doctors with the information they need to make treatment decisions. One of our main goals is to help older men with low testosterone remain healthy and independent longer than would have been possible otherwise.”

Men will be randomly assigned to a treatment group or a control group. Men in the treatment group will be given a testosterone gel to apply to the torso, abdomen or upper arm, while men in the control group will receive a placebo gel. The study will last one year.

The T-Trial will include separate studies focusing on decreased physical function, low vitality, reduced sexual function, impaired cognition and anemia. The trial is financed largely by the National Institute on Aging and coordinated by the University of Pennsylvania.

Men interested in participating in the trial should call the Yale study center at 737-5672 or toll-free at (877) 523-5672, or e-mail Ttrial@yale.edu. Men living within 50 miles of the Yale Medical School and New Haven are especially sought.

For more information, go to www.ttrial.org.

Date: Nov 8, 2009

To see more of New Haven Register, or to subscribe to the newspaper, go to http://www.nhregister.com.

Copyright © 2009, New Haven Register, Conn.

Distributed by McClatchy-Tribune Information Services.

The Yale School of Medicine is seeking older men for a major clinical study to test whether testosterone therapy can reduce health problems such as decreased physical and sexual function, impaired cognition and cardiovascular disease.

The Testosterone Trial at Yale University and 11 other sites across the nation will include 800 men age 65 and older with low testosterone levels, according to a press release.

"As men age, testosterone levels decline, which may lead to many conditions that are often attributed to age alone," said Dr. Thomas M. Gill, professor of medicine at Yale and a specialist in the health of older adults. "The T-Trial is designed to provide definitive evidence on whether testosterone can reverse these conditions.

"If we find that it is a beneficial therapy, this would provide men and their doctors with the information they need to make treatment decisions. One of our main goals is to help older men with low testosterone remain healthy and independent longer than would have been possible otherwise."

Men will be randomly assigned to a treatment group or a control group. Men in the treatment group will be given a testosterone gel to apply to the torso, abdomen or upper arm, while men in the control group will receive a placebo gel. The study will last one year.

The T-Trial will include separate studies focusing on decreased physical function, low vitality, reduced sexual function, impaired cognition and anemia. The trial is financed largely by the National Institute on Aging and coordinated by the University of Pennsylvania.

Men interested in participating in the trial should call the Yale study center at 737-5672 or toll-free at (877) 523-5672, or e-mail Ttrial@yale.edu. Men living within 50 miles of the Yale Medical School and New Haven are especially sought.

For more information, go to www.ttrial.org.

Date: Nov 8, 2009

To see more of New Haven Register, or to subscribe to the newspaper, go to http://www.nhregister.com.

Copyright © 2009, New Haven Register, Conn.

Distributed by McClatchy-Tribune Information Services.

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WIC To Get a Healthy Makeover

Posted Sept 30, 2009

It’s no secret that fruit, vegetables and low-fat milk are part of a balanced diet.

Still, one federal program is just now taking note, adding these essentials to a program for low-income pregnant women, infants and young children.

Starting Oct. 1, the Women, Infants and Children program will provide for the first time checks or vouchers for whole grain bread and fresh, frozen or canned fruit and vegetables. It’s the first major revision to the food offered in the program, which was launched in 1974 to combat anemia and malnutrition.

“Now I don’t have to struggle or decide, ‘Am I going to have enough money to buy this?’” said WIC recipient Nereyda Jaimes of Tampa, who at times struggles to find money to buy fruit and vegetables for her 2-year-old daughter. “Now I know I have it. I’m going to be able to use the voucher and get healthy.”

Federal bureaucracy and evolving research are partly to blame for slowing changes to the program, said Barbara Toth, a nutrition specialist at the Pinellas County Health Department. It also reflects an adjustment in national dietary concerns. Iron deficiency was a crisis when WIC started, but poor and low-income children now are part of the nation’s growing problem with obesity, she said.

“Hopefully this will be a start to introduce lower fats and more fiber to the family,” Toth said.

Nationwide, WIC serves about 8.2 million people, most of whom are infants and children up to age 5. There are 35,795 Hillsborough County children, breast-feeding mothers and pregnant women, and an additional 20,000 in Pinellas County now enrolled. Applicants must reapply every six months to remain eligible.

Under the new plan, children 1 year or older will receive less milk, cheese and fruit juices than before, and cereal choices will be revised to include whole grain options. Previous cereal choices focused on increasing iron, not fiber. In exchange for these reductions, WIC recipients will be awarded vouchers for whole grain breads, brown rice or corn tortillas, and a $6 voucher for vegetables and fruit each month. Infants 6 to 11 months also will have the option of getting baby food featuring fruit and vegetables for the first time.

WIC also is beefing up its offerings for breast-feeding mothers, which the program thinks can be the best source of nutrition for an infant. Mothers who are fully breast-feeding their children will get vouchers for whole grains, fruit and vegetables, as well as supplements for canned tuna or salmon. WIC supplements decrease if formula becomes the main or lone source of nutrition.

All of these food voucher changes did not increase the size of the $6.86 billion federal WIC budget. And it doesn’t change the understanding that WIC serves as a supplemental nutrition program for families whose gross income falls at or below 185 percent of the U.S. Poverty Income Guidelines. Eligible families of four would make $39,200 a year or less.

Nutritionists think the change in the kind of milk allowed will make the biggest impact. Children 2 and older will no longer receive whole milk. Instead, vouchers will only be good for 1 percent or fat-free milk. Hillsborough’s WIC offices began promoting that switch in March to help families adjust.

“It’s huge; it helps us fight overweight and obesity,” said Jennifer Ozimek, a Hillsborough County Health Department nutrition specialist.

Jaimes, 22, said she already has been buying lower-fat milk, and using her own money to buy fruit and vegetables for her daughter, Yarely Orozco. She said she sees how nutrition gets neglected with some children, and she knows she wants to avoid potential health problems for Yarely.

“I’m trying to avoid her getting big. I see now children that are 3, 4, and they’re really overweight for their age. I don’t want her to go through that,” said Jaimes, who brags that her daughter already likes lettuce and broccoli dipped in ranch dressing.

Ozimek said persuading parents to feed children more healthful foods will be the most difficult part of the WIC food transition. Adults are the ones selecting the groceries, and they themselves may prefer whole milk, or disdain fruit and vegetables. However, adults need to make the changes, too, she said.

“The children don’t need all that saturated fat and cholesterol,” Ozimek said, “And neither do the adults.”

Reporter Mary Shedden can be reached at (813) 259-7365.

To see more of the Tampa Tribune or to subscribe to the newspaper, go to http://www.tampatrib.com.

Copyright © 2009, Tampa Tribune, Fla.

Date: Sept 27, 2009

It's no secret that fruit, vegetables and low-fat milk are part of a balanced diet.

Still, one federal program is just now taking note, adding these essentials to a program for low-income pregnant women, infants and young children.

Starting Oct. 1, the Women, Infants and Children program will provide for the first time checks or vouchers for whole grain bread and fresh, frozen or canned fruit and vegetables. It's the first major revision to the food offered in the program, which was launched in 1974 to combat anemia and malnutrition.

"Now I don't have to struggle or decide, 'Am I going to have enough money to buy this?'" said WIC recipient Nereyda Jaimes of Tampa, who at times struggles to find money to buy fruit and vegetables for her 2-year-old daughter. "Now I know I have it. I'm going to be able to use the voucher and get healthy."

Federal bureaucracy and evolving research are partly to blame for slowing changes to the program, said Barbara Toth, a nutrition specialist at the Pinellas County Health Department. It also reflects an adjustment in national dietary concerns. Iron deficiency was a crisis when WIC started, but poor and low-income children now are part of the nation's growing problem with obesity, she said.

"Hopefully this will be a start to introduce lower fats and more fiber to the family," Toth said.

Nationwide, WIC serves about 8.2 million people, most of whom are infants and children up to age 5. There are 35,795 Hillsborough County children, breast-feeding mothers and pregnant women, and an additional 20,000 in Pinellas County now enrolled. Applicants must reapply every six months to remain eligible.

Under the new plan, children 1 year or older will receive less milk, cheese and fruit juices than before, and cereal choices will be revised to include whole grain options. Previous cereal choices focused on increasing iron, not fiber. In exchange for these reductions, WIC recipients will be awarded vouchers for whole grain breads, brown rice or corn tortillas, and a $6 voucher for vegetables and fruit each month. Infants 6 to 11 months also will have the option of getting baby food featuring fruit and vegetables for the first time.

WIC also is beefing up its offerings for breast-feeding mothers, which the program thinks can be the best source of nutrition for an infant. Mothers who are fully breast-feeding their children will get vouchers for whole grains, fruit and vegetables, as well as supplements for canned tuna or salmon. WIC supplements decrease if formula becomes the main or lone source of nutrition.

All of these food voucher changes did not increase the size of the $6.86 billion federal WIC budget. And it doesn't change the understanding that WIC serves as a supplemental nutrition program for families whose gross income falls at or below 185 percent of the U.S. Poverty Income Guidelines. Eligible families of four would make $39,200 a year or less.

Nutritionists think the change in the kind of milk allowed will make the biggest impact. Children 2 and older will no longer receive whole milk. Instead, vouchers will only be good for 1 percent or fat-free milk. Hillsborough's WIC offices began promoting that switch in March to help families adjust.

"It's huge; it helps us fight overweight and obesity," said Jennifer Ozimek, a Hillsborough County Health Department nutrition specialist.

Jaimes, 22, said she already has been buying lower-fat milk, and using her own money to buy fruit and vegetables for her daughter, Yarely Orozco. She said she sees how nutrition gets neglected with some children, and she knows she wants to avoid potential health problems for Yarely.

"I'm trying to avoid her getting big. I see now children that are 3, 4, and they're really overweight for their age. I don't want her to go through that," said Jaimes, who brags that her daughter already likes lettuce and broccoli dipped in ranch dressing.

Ozimek said persuading parents to feed children more healthful foods will be the most difficult part of the WIC food transition. Adults are the ones selecting the groceries, and they themselves may prefer whole milk, or disdain fruit and vegetables. However, adults need to make the changes, too, she said.

"The children don't need all that saturated fat and cholesterol," Ozimek said, "And neither do the adults."

Reporter Mary Shedden can be reached at (813) 259-7365.

To see more of the Tampa Tribune or to subscribe to the newspaper, go to http://www.tampatrib.com.

Copyright © 2009, Tampa Tribune, Fla.

Date: Sept 27, 2009

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You might be allergic to wheat and not know it

Celiac Disease on the Rise?

Celiac disease, an immune system reaction to gluten in the diet, is more than four times more common today than it was 50 years ago, U.S. researchers say.

Dr. Joseph Murray of Mayo Clinic in Rochester, Minn., also found that subjects who did not know they had celiac disease were nearly four times more likely than celiac-free subjects to have died during the 45 years of follow-up.

"Celiac disease has become much more common in the last 50 years, and we don't know why," Murray said in a statement. "It now affects about one in a hundred people."

In patients with celiac disease, the presence of the protein gluten from wheat, barley or rye triggers an immune system attack, damaging the villi in the small intestine. Villi are fingerlike projections that increase the intestine's surface area for nutrient absorption, Murray said.

The researchers tested blood samples gathered at Warren Air Force Base in Wyoming between 1948 and 1954 for the antibody that people with celiac disease produce in reaction to gluten. The study, published in the journal Gastroenterology, found young people today are 4.5 times more likely to have celiac disease than young people were in the 1950s.

"Something has changed in our environment to make it much more common," Murray said. "Until recently, the standard approach to finding celiac disease has been to wait for people to complain of symptoms and to come to the doctor for investigation."

Celiac article #2:
Many Celiacs Go Undiagnosed

For people newly diagnosed with celiac disease, an autoimmune disorder of the small intestine, the world can seem upside down.

Whole-wheat bread, granola, bran cereal -- staples of a healthy diet -- suddenly are poisonous, capable of causing malnutrition, neurological problems, infertility, even cancer down the road. For those with severe cases, ingestion of the tiniest morsel of wheat or gluten, a protein found in wheat, rye and barley, can trigger severe abdominal pains and diarrhea.

Though rare, celiac disease is dramatically on the rise, according to the results of a newly released study by scientists at the Mayo Clinic.

The widely accepted statistic is that one in 133 people has celiac disease, or about 1 percent of the population, but the more alarming statistic is that the majority of people who have celiac don't know it.

Henry J. Binder, a professor of medicine at Yale School of Medicine, calls celiac an "iceberg" disease.

"Individuals who have been diagnosed because they have symptoms would be the small tip of the iceberg," he said.

Those without the classic digestive symptoms, or with no symptoms at all, represent the bulk of the iceberg that remains underwater.

"There's the potential for a very large number of individuals having celiac disease," he said.

Celiac disease is four times more common now than it was 50 years ago, according to a major study by Joseph Murray and other doctors at the Mayo Clinic, published in this month's issue of the journal, Gastroenterology.

The study compared blood samples collected from 9,133 adults between 1948 and 1954 at the Warren Air Force Base in Wyoming to blood samples taken more recently from 12,768 people in Olmsted County, Minn. The samples were tested for antibodies commonly present when a person has celiac disease and has been eating gluten-containing food. In addition to a rise in the disease, researchers discovered that people whose blood tested positive for celiac disease in the 1950s, but didn't know they had celiac, were four times more likely to die sooner.

The findings raise new questions about whether the general population should be screened for the disease, or if doctors should continue to screen only people who have risk factors for developing the disease -- people with a family member who has celiac or people with autoimmune disorders, like type 1 diabetes and thyroid disease. Other symptoms besides the classic digestive ones that could indicate celiac are anemia, vitamin deficiency, infertility, weight loss and bone disorders.

With the sharp rise in the prevalence of celiac disease comes a parallel increase in awareness of the disorder and options for gluten-free living. Celiac disease is easily treated by completely eliminating gluten-containing foods from a person's diet. A person diagnosed several decades ago had a more difficult time finding gluten-free items at local supermarkets and health-food stores.

Bill Jacobs, president of the Greater New Haven Celiac Group, a support network for people with the disease, got his diagnosis in 1982. He was 32.

After going through myriad tests and getting a misdiagnosis of stomach ulcers along the way, Jacobs' gastroenterologist discovered the cause of stomach woes -- celiac disease.

"I never heard of it in my life," said Jacobs, who lives in Cheshire and has been glutenfree since his diagnosis.

At first, Jacobs spent hours in the grocery store reading labels and looking for foods safe for him to eat.

"The problem was when I got the gluten-free list, it was like going on a scavenger hunt in the store," he recalled.

But in the several decades since his diagnosis, the world has become an increasingly celiacfriendly place. So when Jacobs' daughter, Keri Jacobs, was diagnosed several years ago at age 13, the transition to gluten-free living was smoother.

"The fact that my dad has it and I see how he has to eat makes it easier," said Keri, now 17 and newly graduated from Cheshire High School.

Keri Jacobs is a classic example of someone who had no symptoms of celiac disease but was screened for it because of her dad.

Her blood work was "off the charts," according to her dad, and a biopsy of her small intestine revealed extensive damage.

Camaraderie is a big thing for people with celiac disease because the condition can be isolating. When Keri and Bill Jacobs discovered Ernie's Pizzeria on Whalley Avenue, where you can special-order a gluten-free pizza, the experience was emotional.

"It was really nice to be able to go out and have pizza with my family," Keri said.

The need for a celiac network to help newly diagnosed people is what led Jane Trevett to cofound the Greater New Haven Celiac Group with friend and fellow celiac sufferer Beverly Chevalier more than a decade ago.

When the Greater New Haven Celiac Group first met in 1996, there were 15 people. Now the group has 275 members and is growing.

Over the years, Trevett has seen an increase in the quantity but also the quality of gluten-free food.

"When I first started eating gluten-free food, my husband wouldn't go near it. Now when I make a brownie mix, I can't keep him away," she said.

Health-food markets such of Edge of the Woods in New Haven and Thyme & Season in Hamden offer extensive gluten-free options. Local restaurants like Ernie's Pizzeria and Claire's Corner Copia on Chapel Street have gluten-free menu items. Even some bakeries like Dee's One Smart Cookie in Glastonbury have tuned into the need.

Hamden-based gluten-free foodie Jennifer Rafferty keeps a blog, www.glutenfreeinspired. com, where she offers local restaurant and product reviews and musings from a gluten-free perspective. Her blog gets about 60 visits per day on average.

Schools and universities are starting to respond to the growing demand for gluten-free options as well.

Robert Landolphi, culinary operations manager at the University of Connecticut, helped create a comprehensive gluten-free plan for students there.

What started as small changes to the menu evolved into the development of a substantial gluten-free program for students and staff members who have celiac.

For Mexican dishes, Landolphi uses corn instead of flour tortillas.


Celiac article #3:
Is This Hidden Allergy Hijacking Your Good Health?

The only thing worse than knowing you have celiac disease is not knowing that you have it-and just one look at the trademark signs of this devastating disorder provides ample evidence of that. Yet research suggests that as many as 97 percent of celiac sufferers will remain undiagnosed... and if you've been watching your health spiral out of control with no apparent cause to speak of, then you may just be one of them.1

Celiac disease (CD) is a genetic disorder characterized by an extreme allergic reaction to wheat-and more specifically, the protein gluten and its subfraction gliadin-in your digestive tract. When you have CD, even the smallest amount of gluten in your diet can trigger an immune assault on the lining of your small intestine, giving way to chronic bowel inflammation-and all of the numerous (and potentially deadly) complications that come with it.2-3

Diarrhea, constipation, weight problems, and the poor absorption of critical nutrients-including iron, calcium, magnesium, potassium, B vitamins, and essential fatty acids, to name a few-are just the beginning. In time, CD can affect just about every system in your body. Diabetes, osteoporosis, and abdominal cancer are all linked to celiac disease... and believe it or not, clinical depression is one of the best indications that you're suffering from an undiagnosed case of this very dangerous condition.4

Making matters worse is the frustrating fact that wheat gluten is everywhere. Sure, there are the usual suspects-like bread, pasta, and cereal. But you'll also find wheat flour as filler in cold cuts, a thickening agent in sauces, a binding agent in many pharmaceuticals-even dusted on frozen vegetables.5

When it comes to celiac disease, there's no question that knowing your enemy is half the battle-and that positively identifying your condition is absolutely critical. Because while removing all of these gluten sources from your diet may sound like an impossible task, it's also a necessary one if you suffer from CD.6

So how can you be sure that wheat is the culprit behind your bad health? Well, an intestinal biopsy is considered the gold standard in testing-but if you're looking for a less invasive option, there are simple blood tests available, too. In fact, VRP offers one inexpensive option that doesn't even require a trip to your doctor for reliably accurate results.7

The Celiac Antibody Profile is an easy-to-perform finger-prick blood spot test, complete with all of the necessary materials for both collection and free shipping to a screening laboratory. The results of your test will be delivered within 10 to 14 days of receipt, alerting you of your body's individual gluten sensitivity profile-and allowing you to start tackling this dangerous hidden health threat with the certainty you deserve.

References:

1. Celiac Disease Statistics Jefferson Adams Published 6/26/06; Celiac Disease facts and figures, University of Chicago Celiac Center.

2. James Braly MD. Food Allergy Relief. 2000.

3. James Braly MD & Patrick Holford. Hidden Food Allergies. Basic Health Publications, Inc. 2006

4. James Braly MD & Patrick Holford. Hidden Food Allergies. Basic Health Publications, Inc. 2006; Canadian Celiac Association "Celiac Disease" Dr. Mohsin Rashid.

5. Dr James Braly's Food Allergy and Nutrition Revolution 1992; Canadian Celiac Association "Celiac Disease" Dr. Mohsin Rashid.

6. Canadian Celiac Association "Celiac Disease" Dr. Mohsin Rashid; James Braly MD & Ron Hoggan MA. Dangerous Grains. Avery. 2002.

7. James Braly MD & Patrick Holford. Hidden Food Allergies. Basic Health Publications, Inc. 2006; James Braly MD. Food Allergy Relief. James Braly MD 2000.

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Iron Deficiency and Anemia

Posted Sept 14, 2009

Q: I’m a 14-year-old female. I have anemia and a lack of iron. I’m NOT on a diet and I’ve never been on one. I try to eat more meat, but it’s not always available at home. What other problems, except fatigue, can anemia cause?

A: First you have to be sure that you are indeed anemic and if you are that it is from a lack of iron. There are many causes of anemia. How did you find out that you were anemic? Was this diagnosed by a medical professional based on blood tests? It is certainly possible for a teenaged female to have iron deficiency especially if she has heavy menstrual periods.

The best source of dietary iron is from animal sources- meats, poultry and fish but one may also get iron from other sources such as iron fortified cereals and whole wheat bread and from green leafy vegetables and raisins. You can go on line and pull up large list of iron containing foods. Also iron absorption is improved by Vitamin C, another good reason for the vegetables and also fruit.

It is recommended that females of your age should have 15mgm of iron per day. If you are indeed anemic the amount will be increased. If you feel that you cannot get sufficient iron in your diet you can purchase iron tablets, Ferrous Sulfate, and depending on the degree of your anemia take one or two pills a day. This form of iron is very inexpensive. You should have your blood hemoglobin (iron) and iron stores rechecked in about four weeks and if they are normal stop the iron supplement.

Fatigue and lethargy are probably the most common problem with anemia and lack of iron but they may be late manifestations. Even before the anemia shows up the iron stores are depleted and should be replaced. There are other less apparent consequences of iron deficiency such as decreased absorption of other nutrients and minor decreases in mental function but these can all be corrected.

Finally as we said at beginning be sure you are not self diagnosing and that you get proper follow up.

Date: Sept 3, 2009

To have TeenGrowth’s board of physicians answer your health question, visit the Web site (http://www.teengrowth.com) or e-mail feedback@teengrowth.com. TeenGrowth is a non-commercial Internet site that focuses exclusively on the educational health issues of adolescents.

© 2009, KG Investments, LLC.

Distributed by McClatchy-Tribune Information Services.

Q: I'm a 14-year-old female. I have anemia and a lack of iron. I'm NOT on a diet and I've never been on one. I try to eat more meat, but it's not always available at home. What other problems, except fatigue, can anemia cause?

A: First you have to be sure that you are indeed anemic and if you are that it is from a lack of iron. There are many causes of anemia. How did you find out that you were anemic? Was this diagnosed by a medical professional based on blood tests? It is certainly possible for a teenaged female to have iron deficiency especially if she has heavy menstrual periods.

The best source of dietary iron is from animal sources- meats, poultry and fish but one may also get iron from other sources such as iron fortified cereals and whole wheat bread and from green leafy vegetables and raisins. You can go on line and pull up large list of iron containing foods. Also iron absorption is improved by Vitamin C, another good reason for the vegetables and also fruit.

It is recommended that females of your age should have 15mgm of iron per day. If you are indeed anemic the amount will be increased. If you feel that you cannot get sufficient iron in your diet you can purchase iron tablets, Ferrous Sulfate, and depending on the degree of your anemia take one or two pills a day. This form of iron is very inexpensive. You should have your blood hemoglobin (iron) and iron stores rechecked in about four weeks and if they are normal stop the iron supplement.

Fatigue and lethargy are probably the most common problem with anemia and lack of iron but they may be late manifestations. Even before the anemia shows up the iron stores are depleted and should be replaced. There are other less apparent consequences of iron deficiency such as decreased absorption of other nutrients and minor decreases in mental function but these can all be corrected.

Finally as we said at beginning be sure you are not self diagnosing and that you get proper follow up.

Date: Sept 3, 2009

To have TeenGrowth's board of physicians answer your health question, visit the Web site (http://www.teengrowth.com) or e-mail feedback@teengrowth.com. TeenGrowth is a non-commercial Internet site that focuses exclusively on the educational health issues of adolescents.

© 2009, KG Investments, LLC.

Distributed by McClatchy-Tribune Information Services.

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Many Celiacs Go Undiagnosed

Posted Aug 23, 2009

For people newly diagnosed with celiac disease, an autoimmune disorder of the small intestine, the world can seem upside down.

Whole-wheat bread, granola, bran cereal — staples of a healthy diet — suddenly are poisonous, capable of causing malnutrition, neurological problems, infertility, even cancer down the road. For those with severe cases, ingestion of the tiniest morsel of wheat or gluten, a protein found in wheat, rye and barley, can trigger severe abdominal pains and diarrhea.

Though rare, celiac disease is dramatically on the rise, according to the results of a newly released study by scientists at the Mayo Clinic.

The widely accepted statistic is that one in 133 people has celiac disease, or about 1 percent of the population, but the more alarming statistic is that the majority of people who have celiac don’t know it.

Henry J. Binder, a professor of medicine at Yale School of Medicine, calls celiac an “iceberg” disease.

“Individuals who have been diagnosed because they have symptoms would be the small tip of the iceberg,” he said.

Those without the classic digestive symptoms, or with no symptoms at all, represent the bulk of the iceberg that remains underwater.

“There’s the potential for a very large number of individuals having celiac disease,” he said.

Celiac disease is four times more common now than it was 50 years ago, according to a major study by Joseph Murray and other doctors at the Mayo Clinic, published in this month’s issue of the journal, Gastroenterology.

The study compared blood samples collected from 9,133 adults between 1948 and 1954 at the Warren Air Force Base in Wyoming to blood samples taken more recently from 12,768 people in Olmsted County, Minn. The samples were tested for antibodies commonly present when a person has celiac disease and has been eating gluten-containing food. In addition to a rise in the disease, researchers discovered that people whose blood tested positive for celiac disease in the 1950s, but didn’t know they had celiac, were four times more likely to die sooner.

The findings raise new questions about whether the general population should be screened for the disease, or if doctors should continue to screen only people who have risk factors for developing the disease — people with a family member who has celiac or people with autoimmune disorders, like type 1 diabetes and thyroid disease. Other symptoms besides the classic digestive ones that could indicate celiac are anemia, vitamin deficiency, infertility, weight loss and bone disorders.

With the sharp rise in the prevalence of celiac disease comes a parallel increase in awareness of the disorder and options for gluten-free living. Celiac disease is easily treated by completely eliminating gluten-containing foods from a person’s diet. A person diagnosed several decades ago had a more difficult time finding gluten-free items at local supermarkets and health-food stores.

Bill Jacobs, president of the Greater New Haven Celiac Group, a support network for people with the disease, got his diagnosis in 1982. He was 32.

After going through myriad tests and getting a misdiagnosis of stomach ulcers along the way, Jacobs’ gastroenterologist discovered the cause of stomach woes — celiac disease.

“I never heard of it in my life,” said Jacobs, who lives in Cheshire and has been glutenfree since his diagnosis.

At first, Jacobs spent hours in the grocery store reading labels and looking for foods safe for him to eat.

“The problem was when I got the gluten-free list, it was like going on a scavenger hunt in the store,” he recalled.

But in the several decades since his diagnosis, the world has become an increasingly celiacfriendly place. So when Jacobs’ daughter, Keri Jacobs, was diagnosed several years ago at age 13, the transition to gluten-free living was smoother.

“The fact that my dad has it and I see how he has to eat makes it easier,” said Keri, now 17 and newly graduated from Cheshire High School.

Keri Jacobs is a classic example of someone who had no symptoms of celiac disease but was screened for it because of her dad.

Her blood work was “off the charts,” according to her dad, and a biopsy of her small intestine revealed extensive damage.

Camaraderie is a big thing for people with celiac disease because the condition can be isolating. When Keri and Bill Jacobs discovered Ernie’s Pizzeria on Whalley Avenue, where you can special-order a gluten-free pizza, the experience was emotional.

“It was really nice to be able to go out and have pizza with my family,” Keri said.

The need for a celiac network to help newly diagnosed people is what led Jane Trevett to cofound the Greater New Haven Celiac Group with friend and fellow celiac sufferer Beverly Chevalier more than a decade ago.

When the Greater New Haven Celiac Group first met in 1996, there were 15 people. Now the group has 275 members and is growing.

Over the years, Trevett has seen an increase in the quantity but also the quality of gluten-free food.

“When I first started eating gluten-free food, my husband wouldn’t go near it. Now when I make a brownie mix, I can’t keep him away,” she said.

Health-food markets such of Edge of the Woods in New Haven and Thyme & Season in Hamden offer extensive gluten-free options. Local restaurants like Ernie’s Pizzeria and Claire’s Corner Copia on Chapel Street have gluten-free menu items. Even some bakeries like Dee’s One Smart Cookie in Glastonbury have tuned into the need.

Hamden-based gluten-free foodie Jennifer Rafferty keeps a blog, www.glutenfreeinspired. com, where she offers local restaurant and product reviews and musings from a gluten-free perspective. Her blog gets about 60 visits per day on average.

Schools and universities are starting to respond to the growing demand for gluten-free options as well.

Robert Landolphi, culinary operations manager at the University of Connecticut, helped create a comprehensive gluten-free plan for students there.

What started as small changes to the menu evolved into the development of a substantial gluten-free program for students and staff members who have celiac.

For Mexican dishes, Landolphi uses corn instead of flour tortillas.

The kitchen switched to a gluten-free soy sauce for its stir-fries and offers gluten-free cold cuts and gluten free bread for sandwiches. There’s even a gluten-free toaster available to students to ensure no cross-contamination.

“I think we’re doing a pretty good job,” Landolphi said.

The university now offers gluten-free options for every meal at every cafeteria on campus.

And the number of students and faculty members needing glutenfree meals has grown too, from a handful in 2000 to more than 60 now.

Landolphi, whose wife has celiac disease, has even written a cookbook called Gluten Free Everyday.

And there’s more good news for people with celiac disease. Binder noted that scientists are hard at work trying to develop a pill people can take that will make it safe to eat gluten-containing food.

Even without a miracle pill, gluten-free living is getting easier and easier, says Trevett. And she knows, having had the disease for four decades.

“I have gluten-free pizza in my freezer,” she said. “Did I ever think this would be possible? Forget it.”

Date: July 27, 2009

To see more of New Haven Register, or to subscribe to the newspaper, go to http://www.nhregister.com.

Copyright © 2009, New Haven Register, Conn.

For people newly diagnosed with celiac disease, an autoimmune disorder of the small intestine, the world can seem upside down.

Whole-wheat bread, granola, bran cereal -- staples of a healthy diet -- suddenly are poisonous, capable of causing malnutrition, neurological problems, infertility, even cancer down the road. For those with severe cases, ingestion of the tiniest morsel of wheat or gluten, a protein found in wheat, rye and barley, can trigger severe abdominal pains and diarrhea.

Though rare, celiac disease is dramatically on the rise, according to the results of a newly released study by scientists at the Mayo Clinic.

The widely accepted statistic is that one in 133 people has celiac disease, or about 1 percent of the population, but the more alarming statistic is that the majority of people who have celiac don't know it.

Henry J. Binder, a professor of medicine at Yale School of Medicine, calls celiac an "iceberg" disease.

"Individuals who have been diagnosed because they have symptoms would be the small tip of the iceberg," he said.

Those without the classic digestive symptoms, or with no symptoms at all, represent the bulk of the iceberg that remains underwater.

"There's the potential for a very large number of individuals having celiac disease," he said.

Celiac disease is four times more common now than it was 50 years ago, according to a major study by Joseph Murray and other doctors at the Mayo Clinic, published in this month's issue of the journal, Gastroenterology.

The study compared blood samples collected from 9,133 adults between 1948 and 1954 at the Warren Air Force Base in Wyoming to blood samples taken more recently from 12,768 people in Olmsted County, Minn. The samples were tested for antibodies commonly present when a person has celiac disease and has been eating gluten-containing food. In addition to a rise in the disease, researchers discovered that people whose blood tested positive for celiac disease in the 1950s, but didn't know they had celiac, were four times more likely to die sooner.

The findings raise new questions about whether the general population should be screened for the disease, or if doctors should continue to screen only people who have risk factors for developing the disease -- people with a family member who has celiac or people with autoimmune disorders, like type 1 diabetes and thyroid disease. Other symptoms besides the classic digestive ones that could indicate celiac are anemia, vitamin deficiency, infertility, weight loss and bone disorders.

With the sharp rise in the prevalence of celiac disease comes a parallel increase in awareness of the disorder and options for gluten-free living. Celiac disease is easily treated by completely eliminating gluten-containing foods from a person's diet. A person diagnosed several decades ago had a more difficult time finding gluten-free items at local supermarkets and health-food stores.

Bill Jacobs, president of the Greater New Haven Celiac Group, a support network for people with the disease, got his diagnosis in 1982. He was 32.

After going through myriad tests and getting a misdiagnosis of stomach ulcers along the way, Jacobs' gastroenterologist discovered the cause of stomach woes -- celiac disease.

"I never heard of it in my life," said Jacobs, who lives in Cheshire and has been glutenfree since his diagnosis.

At first, Jacobs spent hours in the grocery store reading labels and looking for foods safe for him to eat.

"The problem was when I got the gluten-free list, it was like going on a scavenger hunt in the store," he recalled.

But in the several decades since his diagnosis, the world has become an increasingly celiacfriendly place. So when Jacobs' daughter, Keri Jacobs, was diagnosed several years ago at age 13, the transition to gluten-free living was smoother.

"The fact that my dad has it and I see how he has to eat makes it easier," said Keri, now 17 and newly graduated from Cheshire High School.

Keri Jacobs is a classic example of someone who had no symptoms of celiac disease but was screened for it because of her dad.

Her blood work was "off the charts," according to her dad, and a biopsy of her small intestine revealed extensive damage.

Camaraderie is a big thing for people with celiac disease because the condition can be isolating. When Keri and Bill Jacobs discovered Ernie's Pizzeria on Whalley Avenue, where you can special-order a gluten-free pizza, the experience was emotional.

"It was really nice to be able to go out and have pizza with my family," Keri said.

The need for a celiac network to help newly diagnosed people is what led Jane Trevett to cofound the Greater New Haven Celiac Group with friend and fellow celiac sufferer Beverly Chevalier more than a decade ago.

When the Greater New Haven Celiac Group first met in 1996, there were 15 people. Now the group has 275 members and is growing.

Over the years, Trevett has seen an increase in the quantity but also the quality of gluten-free food.

"When I first started eating gluten-free food, my husband wouldn't go near it. Now when I make a brownie mix, I can't keep him away," she said.

Health-food markets such of Edge of the Woods in New Haven and Thyme & Season in Hamden offer extensive gluten-free options. Local restaurants like Ernie's Pizzeria and Claire's Corner Copia on Chapel Street have gluten-free menu items. Even some bakeries like Dee's One Smart Cookie in Glastonbury have tuned into the need.

Hamden-based gluten-free foodie Jennifer Rafferty keeps a blog, www.glutenfreeinspired. com, where she offers local restaurant and product reviews and musings from a gluten-free perspective. Her blog gets about 60 visits per day on average.

Schools and universities are starting to respond to the growing demand for gluten-free options as well.

Robert Landolphi, culinary operations manager at the University of Connecticut, helped create a comprehensive gluten-free plan for students there.

What started as small changes to the menu evolved into the development of a substantial gluten-free program for students and staff members who have celiac.

For Mexican dishes, Landolphi uses corn instead of flour tortillas.

The kitchen switched to a gluten-free soy sauce for its stir-fries and offers gluten-free cold cuts and gluten free bread for sandwiches. There's even a gluten-free toaster available to students to ensure no cross-contamination.

"I think we're doing a pretty good job," Landolphi said.

The university now offers gluten-free options for every meal at every cafeteria on campus.

And the number of students and faculty members needing glutenfree meals has grown too, from a handful in 2000 to more than 60 now.

Landolphi, whose wife has celiac disease, has even written a cookbook called Gluten Free Everyday.

And there's more good news for people with celiac disease. Binder noted that scientists are hard at work trying to develop a pill people can take that will make it safe to eat gluten-containing food.

Even without a miracle pill, gluten-free living is getting easier and easier, says Trevett. And she knows, having had the disease for four decades.

"I have gluten-free pizza in my freezer," she said. "Did I ever think this would be possible? Forget it."

Date: July 27, 2009

To see more of New Haven Register, or to subscribe to the newspaper, go to http://www.nhregister.com.

Copyright © 2009, New Haven Register, Conn.

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Going Gluten Free May Help

FOR 20 YEARS, Maurie Ange of El Cerrito suffered from chronic belly aches. A decade ago, she was diagnosed with irritable bowel syndrome and told to exercise more and increase her fiber intake. But the pain, bloating and digestive issues continued into her 60s.

Finally, four years ago, at the suggestion of an osteopath she was seeing for sinus trouble, Ange went on a gluten-free diet, avoiding everything that contained the protein found in wheat (durum, semolina, spelt, kamut, einkorn and faro), barley, rye, contaminated oats, and a host of products including lipstick, soy sauce and pharmaceuticals.

"Ninety percent of my issues are gone," Ange says. "When I fall off the wagon, the pain and yuckiness return."

Ange is one of many who has benefited from gluten-free living. Whether they suffer from gluten intolerance, hope to temper the symptoms of autism, or have been diagnosed with celiac disease, an autoimmune disorder that affects 1 in 133 adults and is getting overdue attention, they are going gluten-free for good, not as a fad. It is a lifestyle that, when approached naturally and under medical supervision, provides relief and bonuses such as avoiding processed and packaged foods.

Still, cutting out gluten is difficult. It requires vigilant label reading and a dedication to eating at home. Most American staples such as pizza, pasta, beer and burgers in their standard form are off limits. On the bright

side, the things you can eat -- proteins and fruits and vegetables -- are good for you.

As a result, Pleasanton personal chef Claudia Imatt has seen an overwhelming surge in the number of requests for gluten-free menus.

"People are requesting it for their ailments," says Imatt, owner of Shall We Dine. "Everything from headaches and weight loss to fatigue, seasonal or wheat allergies and fibromyalgia."

A typical dinner menu emphasizes fruits, greens, proteins and creative spins on rice, corn, beans and potatoes in lieu of wheat-based starches. Imatt struggles to find gluten-free products that meet her standards and don't "break the bank," she says. Overall, she has found that people who come to her for help changing their diet "embrace it and live well. "It's less garbage and less processed foods," she says. "You know where the food is coming from and you can see the ingredients that are in it."

Ten years ago, Kay Junta of Concord marched into her general practitioner's office and told him she was so sick she was afraid she would die. The year before, he had diagnosed her with IBS and sent her to a specialist who put her on medication for digestive issues and abdominal pain. But her health continued to deteriorate. Eventually, she went into malnutrition.

Finally, the doctors performed a blood test and intestinal biopsy. They confirmed the culprit as celiac disease, a multi-system, multi-symptom autoimmune disorder that often mimics the symptoms of other bowel disorders. According to the Celiac Disease Foundation, when individuals with celiac disease ingest gluten, the villi, tiny hairlike projections in the small intestine that absorb nutrients, are damaged. Damaged villi do not effectively absorb basic nutrients such as proteins, carbohydrates, vitamins and minerals.

Junta, a passionate baker, educated herself and eliminated gluten from her entire diet, reading labels for cross-contamination warnings and seeking out celiac-friendly restaurants. She likes the menus at Cheesecake Factory and Pasta Primavera in Concord.

"I have my life back," says Junta, now 65. "But I still have to be careful. Even a breadcrumb can make me very ill." She has even transformed her favorite cake and cookie recipes by using bean or potato flour and relying on yogurt or applesauce as thickening agents. Her friends can't tell the difference, she says. "It's not rocket science," Junta says of living gluten-free. "Do you want to save your life or do you want to go on being sick? I chose not to be sick."

Not everyone with celiac disease has perceptible gastrointestinal symptoms, which can include fatigue, gas, bloating, abdominal pain or chronic diarrhea or constipation. Unexplained anemia and behavioral changes such as depression are not uncommon. If left untreated, damage to the small intestine can be chronic, causing an increased risk of associated disorders and issues such as infertility, intestinal lymphomas and dermatitis herpetiformis, a skin manifestation of celiac disease characterized by blistering, itchy skin.

"It can be a very indolent disease," says Gary M. Gray, professor of gastroenterology at Stanford University and director of its celiac management clinic. "There are a lot of people who have food intolerances but many true celiacs have intermittent symptoms or no symptoms. In most patients it's hard to diagnose."

While the cause of celiac disease is unknown, it is genetic and can be triggered by a viral infection, severe emotional stress, pregnancy or childbirth. So if someone in your family has been diagnosed with it or a related autoimmune disorder, it is best to get tested, Gray says.

The biggest problem is when people go off gluten on their own and then come in to get tested for celiac or gluten intolerance, he adds.

"If they've done it (the diet) for a month or longer, it's likely we can't diagnose it," he says. Furthermore, he adds, some people gain rather than lose weight as a result of the diet because they load up on fat-laden, gluten-free packaged goods.

Like Gray, San Ramon registered dietitian Kathi Nichols doesn't recommend launching into a gluten-free diet without a diagnosis. It's too hard, she says. Nichols, 51, was diagnosed with celiac disease three years ago after seeing numerous physicians for unexplained anemia and dermatitis.

"It is one of the most difficult things I've ever had to do," she says of going gluten-free. "I thought I could just go to the store and buy anything. But a food manufacturer could suddenly change their recipe and add gluten. So it takes twice as long to do a grocery store trip because you have to read everything. And it's more expensive."

The bright side, Nichols says, is that she has discovered food items from different cultures, including a tapioca flour Bolivians use to make rolls. And her disease hasn't kept her from traveling overseas. Quite the contrary. Many celiacs enjoy going to other countries, particularly to England and Australia, where awareness is higher and restaurants are accommodating, Nichols says.

Overall, she advises people to stay focused on what they can eat and remind themselves that there's more to life than diet.

"The only place I have not walked into in years is McDonald's," she says, laughing. "Celiac controls my choices, but it doesn't control my life."

Lori Crowley of San Ramon helped reclaim control of her son's life when she took him off gluten last October. Aidan, 5, suffers from a developmental delay known as sensory integration dysfunction. It affects his ability to balance, process information and discern touch.

"He had these moments where he seemed spaced out," she says. "He also had issues with aggression and compliance."

While her son has not been diagnosed with an autism spectrum disorder, Crowley was aware of the research circulating about the link between diet and developmental issues. According to the Autism Research Institute and Defeat Autism Now, some children with autism cannot properly digest gluten. Instead of passing through the digestive system, the protein breaks down into peptides that leak into the bloodstream of children with ASDs and trigger an opiatelike effect in the brain.

With help from a friend with a celiac child, Crowley made the transition. And, within two weeks, Aidan had changed.

"The spaciness is gone. So is the aggression," Crowley says. "I think the fog in his brain kind of cleared. It doesn't mean that it's gone away. But we've seen profound improvements."

Reach Jessica Yadegaran at 925-943-8155 or jyadegaran@bayareanewsgroup.com.

May 20, 2009

To see more of the Contra Costa Times, or to subscribe to the newspaper, go to http://www.contracostatimes.com/.

Copyright © 2009, Contra Costa Times, Walnut Creek, Calif.

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Study to Examine Environment’s Impact on Kids’ Health

Posted April 7, 2009

Starting this month, thousands of newly pregnant Utahns and potential mothers-to-be will be asked to enroll in the largest study of children ever conducted in the country.

Parents who sign up for the National Children’s Study will join an effort to solve a new mystery in children’s health: How do kids’ genes interact with the water they drink, the air they breathe, the soil they play in and the products they use — to make them sick?

Scientists will be searching from womb to bedroom and beyond to understand why children increasingly suffer chronic diseases, such as asthma and learning disabilities, that have no other known cause.

Researchers will be figuratively — and sometimes literally — peering over mothers’ shoulders, from gauging how close they are to their child to probing how much television or junk food they allow. They’ll scan blood, urine, hair and nails to see what children or mothers are exposed to, from pesticides to drugs to stress.

“We recognize this is very, very intrusive,” says Sean Firth, an epidemiologist and study project director in Utah. “We will become part of their lives.”

Every scrap of information that will be collected is thought to be linked to a particular disease, he says, whether it’s prenatal infection and autism, household dust and asthma, or family dynamics and child development.

“We are going to accomplish great things by pulling this off,” says Firth.

But the massive study — the

goal is to enroll 100,000 children nationwide and follow them to age 21 — also raises ethical questions: How can a parent commit their future child to tests and questions that not even researchers have dreamed up? And what do parents deserve to know about their children’s health and environment — and when?

‘Change the world: In Salt Lake County — one of seven national pilot sites — recruiters will start knocking on the doors of 7,000 households during the last week of April. It could take six months to reach every home in the study boundaries.

They will look for women ages 18 to 49 who are in their first trimester of pregnancy or women who are likely to become pregnant in the next five years. Teens who become pregnant during the study period will also be approached. Biological fathers will be invited, but don’t have to participate for their children to be included.

The study will attempt to address the changing nature of childhood diseases. Although children used to die or suffer from infectious diseases, now their biggest threats are chronic diseases, which arise from the interaction of genes and environment, according to the study.

South Salt Lake mom Bronwen Calver hopes Utah women enroll to possibly help her son or his future children. Julian, 13, has asthma and allergies. While his asthma led to hospitalizations for bacterial pneumonia when he was a toddler — he coughed so much he broke capillaries in his lungs — it’s under control now. Still, on bad-air days during the winter and summer, he uses an inhaler and stays indoors.

“I hear of more and more kids having asthma. You have to wonder if there’s something environmental causing this,” she says. “A lot of people don’t understand how debilitating asthma can be. It makes your world very, very small when you’re sick.”

To build support, the local research team has been meeting with elected officials and community leaders in churches, ethnic organizations and schools.

Julie Miller, principal of Wasatch Elementary in Salt Lake City, is ready to urge parents to participate. She sees more children at school with asthma, allergies and diabetes. “I care [about the study] because I’ve spent a lifetime working with kids. There are things we can do to change the world we live in that will have a better outcome for all of us.”

Breast milk to bedsheets: But on the national level, researchers acknowledge recruitment will be a “significant challenge” due to the burden placed on families. Over two decades, participants are expected to meet with researchers about a dozen times for four hours each, in their homes or at a clinic; keep records of doctor visits and fill out dozens of questionnaires. In the first two years alone, participants will devote 38 hours.

Researchers will take environmental samples from children’s homes, and possibly day care centers and mothers’ workplaces. They will chart graffiti, traffic and recreation spots in the neighborhoods.

They will vacuum household dust from tabletops, floors and bedsheets; take samples of placentas and umbilical-cord blood; collect vaginal swabs during pregnancy and breast milk afterward. They will gauge children’s development, from language to motor skills, even videotaping mothers and infants playing.

Families will be paid $25 an hour for in-home and clinic visits and will receive gift certificates and other incidentals.

Because researchers don’t know what information they will want to gather in the future, parents and children will be told at each visit what to expect. They can bow out at any time, or decide not to participate in certain portions. Children will be asked their opinions around age 7, 14 and 18. If they say “no,” their parents cannot overrule them.

Asking consent before every visit makes the study “ethically stronger than much of what we do otherwise in research,” says Jeffrey Botkin, associate vice president for research integrity at the University of Utah. He raised such ethical issues at the national level as co-chair of the study’s ethics working group.

The commitment “sounds like a lot,” says Andrea Riddle, who is trying to become pregnant with her second child. Nevertheless, the 31-year-old from West Jordan hopes to join, believing research of this magnitude requires the intrusiveness. “It’s always better to know more about what’s affecting children, how children are getting sick, how the environment affects them.”

Gift to the future: If Riddle joins the study, she would want feedback as scientists discover environmental factors that affect children’s health. “If they found your home is not safe — something in the air, pesticides close by that could cause problems with the child — I would hope they would [give] you the information right away.”

But beyond immediately sharing information like blood pressure, height and weight researchers are still working through how they will report other information, prompting criticism from the National Academy of Sciences (NAS). It reviewed the study last year at the federal government’s request.

“Parents are often eager to get research results, regardless of their clinical utility or the availability of effective intervention,” the NAS report said. The review also noted that researchers could be sued if they learn that certain exposures are dangerous and don’t alert families to them.

“They need to have a plan on what they’re going to do,” says Ellen Wright Clayton, co-director of the Center for Biomedical Ethics and Society at Vanderbilt University, who was on the NAS review panel.

She says her personal opinion is that parents should be told, for example, if an ultrasound detects fetal deformities or a blood test reveals anemia. That’s because those are known health effects or risks.

The study’s researchers agree, and also will share information about signs of illnesses or developmental delays. But it’s more complicated with other information. Most biological and environmental samples won’t be analyzed until years later — when and if funding becomes available — delaying when researchers learn of risks.

Another problem: There are no national reporting standards for some samples, such as organophosphates, a chemical used in pesticides, says Edward Clark, chairman of the U.’s pediatrics department and principal investigator of the Utah portion of the study.

So researchers will have to determine what levels are dangerous before reporting to participants — and potentially, neighborhoods.

Somewhere in the country, “We will have another Love Canal,” Clark predicts, referring to a New York neighborhood built on top of toxic waste. “Our pledge is to bring this [information] back in a responsible way so individuals and communities will be aware of it and can develop an appropriate response.”

Scientists will immediately analyze specimens that cannot be stored for long periods of time, including volatile organic compounds, according to Rod Larson, who is in charge of the study’s environmental monitoring in Utah.

Such gasses are emitted from products such as paint, cleaning supplies, furniture and carpet, and are known to cause cancer and organ damage, according to the Environmental Protection Agency. Participants will be told if levels are too high as soon as the information is available, Larson says.

Firth, the Utah study project director, says it wouldn’t make sense to share certain information too soon, when researchers don’t know what level is dangerous. “People [would] look at that and see a big chemical name and think, ‘Holy cow. I’m in trouble.’”

Clayton, who recently joined an advisory committee for the study, agrees and says parents should understand what they are signing up for.

“A lot of people participate in research because they think they’re going to learn something about their own health. … They need to realize that participating in this is a gift to American children and the future.”

hmay@sltrib.com

Date: April 4, 2009

To see more of The Salt Lake Tribune, or to subscribe to the newspaper, go to http://www.sltrib.com.

Copyright © 2009, The Salt Lake Tribune

Starting this month, thousands of newly pregnant Utahns and potential mothers-to-be will be asked to enroll in the largest study of children ever conducted in the country.

Parents who sign up for the National Children's Study will join an effort to solve a new mystery in children's health: How do kids' genes interact with the water they drink, the air they breathe, the soil they play in and the products they use -- to make them sick?

Scientists will be searching from womb to bedroom and beyond to understand why children increasingly suffer chronic diseases, such as asthma and learning disabilities, that have no other known cause.

Researchers will be figuratively -- and sometimes literally -- peering over mothers' shoulders, from gauging how close they are to their child to probing how much television or junk food they allow. They'll scan blood, urine, hair and nails to see what children or mothers are exposed to, from pesticides to drugs to stress.

"We recognize this is very, very intrusive," says Sean Firth, an epidemiologist and study project director in Utah. "We will become part of their lives."

Every scrap of information that will be collected is thought to be linked to a particular disease, he says, whether it's prenatal infection and autism, household dust and asthma, or family dynamics and child development.

"We are going to accomplish great things by pulling this off," says Firth.

But the massive study -- the

goal is to enroll 100,000 children nationwide and follow them to age 21 -- also raises ethical questions: How can a parent commit their future child to tests and questions that not even researchers have dreamed up? And what do parents deserve to know about their children's health and environment -- and when?

'Change the world: In Salt Lake County -- one of seven national pilot sites -- recruiters will start knocking on the doors of 7,000 households during the last week of April. It could take six months to reach every home in the study boundaries.

They will look for women ages 18 to 49 who are in their first trimester of pregnancy or women who are likely to become pregnant in the next five years. Teens who become pregnant during the study period will also be approached. Biological fathers will be invited, but don't have to participate for their children to be included.

The study will attempt to address the changing nature of childhood diseases. Although children used to die or suffer from infectious diseases, now their biggest threats are chronic diseases, which arise from the interaction of genes and environment, according to the study.

South Salt Lake mom Bronwen Calver hopes Utah women enroll to possibly help her son or his future children. Julian, 13, has asthma and allergies. While his asthma led to hospitalizations for bacterial pneumonia when he was a toddler -- he coughed so much he broke capillaries in his lungs -- it's under control now. Still, on bad-air days during the winter and summer, he uses an inhaler and stays indoors.

"I hear of more and more kids having asthma. You have to wonder if there's something environmental causing this," she says. "A lot of people don't understand how debilitating asthma can be. It makes your world very, very small when you're sick."

To build support, the local research team has been meeting with elected officials and community leaders in churches, ethnic organizations and schools.

Julie Miller, principal of Wasatch Elementary in Salt Lake City, is ready to urge parents to participate. She sees more children at school with asthma, allergies and diabetes. "I care [about the study] because I've spent a lifetime working with kids. There are things we can do to change the world we live in that will have a better outcome for all of us."

-

Breast milk to bedsheets: But on the national level, researchers acknowledge recruitment will be a "significant challenge" due to the burden placed on families. Over two decades, participants are expected to meet with researchers about a dozen times for four hours each, in their homes or at a clinic; keep records of doctor visits and fill out dozens of questionnaires. In the first two years alone, participants will devote 38 hours.

Researchers will take environmental samples from children's homes, and possibly day care centers and mothers' workplaces. They will chart graffiti, traffic and recreation spots in the neighborhoods.

They will vacuum household dust from tabletops, floors and bedsheets; take samples of placentas and umbilical-cord blood; collect vaginal swabs during pregnancy and breast milk afterward. They will gauge children's development, from language to motor skills, even videotaping mothers and infants playing.

Families will be paid $25 an hour for in-home and clinic visits and will receive gift certificates and other incidentals.

Because researchers don't know what information they will want to gather in the future, parents and children will be told at each visit what to expect. They can bow out at any time, or decide not to participate in certain portions. Children will be asked their opinions around age 7, 14 and 18. If they say "no," their parents cannot overrule them.

Asking consent before every visit makes the study "ethically stronger than much of what we do otherwise in research," says Jeffrey Botkin, associate vice president for research integrity at the University of Utah. He raised such ethical issues at the national level as co-chair of the study's ethics working group.

The commitment "sounds like a lot," says Andrea Riddle, who is trying to become pregnant with her second child. Nevertheless, the 31-year-old from West Jordan hopes to join, believing research of this magnitude requires the intrusiveness. "It's always better to know more about what's affecting children, how children are getting sick, how the environment affects them."

-

Gift to the future: If Riddle joins the study, she would want feedback as scientists discover environmental factors that affect children's health. "If they found your home is not safe -- something in the air, pesticides close by that could cause problems with the child -- I would hope they would [give] you the information right away."

But beyond immediately sharing information like blood pressure, height and weight researchers are still working through how they will report other information, prompting criticism from the National Academy of Sciences (NAS). It reviewed the study last year at the federal government's request.

"Parents are often eager to get research results, regardless of their clinical utility or the availability of effective intervention," the NAS report said. The review also noted that researchers could be sued if they learn that certain exposures are dangerous and don't alert families to them.

"They need to have a plan on what they're going to do," says Ellen Wright Clayton, co-director of the Center for Biomedical Ethics and Society at Vanderbilt University, who was on the NAS review panel.

She says her personal opinion is that parents should be told, for example, if an ultrasound detects fetal deformities or a blood test reveals anemia. That's because those are known health effects or risks.

The study's researchers agree, and also will share information about signs of illnesses or developmental delays. But it's more complicated with other information. Most biological and environmental samples won't be analyzed until years later -- when and if funding becomes available -- delaying when researchers learn of risks.

Another problem: There are no national reporting standards for some samples, such as organophosphates, a chemical used in pesticides, says Edward Clark, chairman of the U.'s pediatrics department and principal investigator of the Utah portion of the study.

So researchers will have to determine what levels are dangerous before reporting to participants -- and potentially, neighborhoods.

Somewhere in the country, "We will have another Love Canal," Clark predicts, referring to a New York neighborhood built on top of toxic waste. "Our pledge is to bring this [information] back in a responsible way so individuals and communities will be aware of it and can develop an appropriate response."

Scientists will immediately analyze specimens that cannot be stored for long periods of time, including volatile organic compounds, according to Rod Larson, who is in charge of the study's environmental monitoring in Utah.

Such gasses are emitted from products such as paint, cleaning supplies, furniture and carpet, and are known to cause cancer and organ damage, according to the Environmental Protection Agency. Participants will be told if levels are too high as soon as the information is available, Larson says.

Firth, the Utah study project director, says it wouldn't make sense to share certain information too soon, when researchers don't know what level is dangerous. "People [would] look at that and see a big chemical name and think, 'Holy cow. I'm in trouble.'"

Clayton, who recently joined an advisory committee for the study, agrees and says parents should understand what they are signing up for.

"A lot of people participate in research because they think they're going to learn something about their own health. ... They need to realize that participating in this is a gift to American children and the future."

hmay@sltrib.com

Date: April 4, 2009



To see more of The Salt Lake Tribune, or to subscribe to the newspaper, go to http://www.sltrib.com.

Copyright © 2009, The Salt Lake Tribune

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Celiac Diagnosis Gives Life Back to Girl

Posted Mar 26, 2009

Chelsea Wheeler, 6, had her first birthday cake at age 4 and her first take-out pizza only recently. The poignancy of those events isn’t lost on her parents, Chris and Linda Wheeler.

Chelsea suffers from celiac disease, but it took so long to get to that diagnosis — including 20 unnecessary surgeries — that the Wheelers have made it a mission to raise research money and awareness about celiac, a genetic digestive disorder triggered by gluten, a protein found in wheat, barley and rye.

There is no cure or medication for celiac, but a gluten-free diet allows sufferers to lead normal lives. Chelsea’s younger sister, Julia, also has the disease.

Unfortunately, Chelsea went through three years of sickness and life-altering surgeries before she was diagnosed. Since the disease has varied symptoms, from learning disabilities to wrenching intestinal pain, it is often misdiagnosed, so raising awareness even among doctors is a crucial part of the fight.

Chris Wheeler said that one in 133 Americans has celiac, but 95 percent are misdiagnosed.

“Chelsea is a worse case,” Chris Wheeler said. “We just want to raise awareness so no one has to go through what she’s gone through.”

The Wheelers have organized a golf tournament and luncheon fundraiser, “Chip in for Celiac,” which will take place May 15 at Whitney Farms Golf Course in Monroe. The luncheon will be open to those who don’t golf. To sponsor, donate or reserve a spot or for more information, call Wheeler at (203) 463-9422.

After the diagnosis, the Wheelers became involved in the Greater New Haven Celiac Group, Chapter 75 of the Celiac Sprue Association. They heard other people’s stories and shared information, including about gluten-free foods. Now, many people affected by the condition call Linda Wheeler for information or support.

The golf fund-raiser is sponsored by the University of Maryland. The proceeds will go to the university’s Center for Celiac Research, with a portion to be directed to the New Haven group, which is helping with vendors and donations.

Despite having an army of medical specialists trying to find out why Chelsea could not gain weight and was throwing up full feedings as a baby, no one diagnosed Chelsea until Linda Wheeler, a very thin woman who had gone through many bouts of anemia, was found to have celiac.

Celiac hinders absorption of nutrients, often making its victims thin. Since the disease is genetic, Chelsea was tested and found to be positive; her three older siblings, ages 7 to 11, carry the gene and need to be tested every few years to watch for a rise in antibodies, but they don’t exhibit symptoms yet and are not on gluten-free diets. The youngest, Julia, 2, was put on a glutenfree diet when she was unable to keep food down as a baby.

Although Chelsea has significant health problems stemming from her surgeries, she looks the picture of health these days. She has big, dark blue eyes, an engaging manner and a healthy weight.

But that wasn’t always the case.

The Wheelers’ ordeal began when Chelsea was about 2 weeks old and Linda, as instructed by doctors, was thickening her formula with barley. Chelsea, who had been born prematurely, was throwing up full feedings and was not gaining weight.

Suspecting it could be the barley, Linda took it out of Chelsea’s formula about two weeks before she would be tested for celiac disease, among other ailments. The test came back negative because the barley had been out of her diet.

Linda Wheeler began giving her the barley in the bottle again. Chelsea lost so much weight she was admitted to the hospital at 8 months for a “nutrition rescue,” meaning she was fed through an intravenous tube. She continued to throw up and at 11 months old was back in the hospital for another rescue because she had lost so much weight. She was 12.5 pounds at age 1.

Doctors tested for every liver, pancreatic and stomach disease they could think of, but turned up nothing, her parents said. She was seen at Yale-New Haven Hospital, Children’s Medical Center in Hartford and Mount Sinai Hospital in New York.

It was at 13 months old that doctors performed major surgery to cut her stomach away from her spleen so she couldn’t throw up. That surgery brought numerous complications and has left her, among other ailments, with a condition called “dumping” that causes her blood sugar to often spike then drop after eating, leaving her in need of a nap. She also has seizures and takes many daily medications. Because she can’t throw up, when Chelsea gets a stomach bug, she just heaves with no relief, Chris Wheeler said.

In the years after the surgery, she still wasn’t gaining weight. She was dependent on a feeding tube that entailed carrying equipment everywhere the family went.

Then, at about age 3 1/2, when the celiac disease diagnosis came for mom, Chelsea was finally properly diagnosed. A gluten-free diet was the simple remedy. Chelsea had been through 30 surgeries, 10 of them connected to trying to diagnose her problem.

“We look at the world in a different way; things that used to seem important aren’t important anymore,” Linda Wheeler said.

Bill Jacobs, president of the New Haven group, called Chelsea’s story a sad one and said any money that goes toward the group from the golf tournament will be well spent on its many activities, including workshops, bringing in expert speakers on celiac and other supports, including updates on gluten-free food products and restaurant menus and a newsletter.

For more information on the group call Jacobs at 272-9646.

Jacobs was diagnosed 28 years ago and his daughter, now 17, was put on a gluten-free diet at age 13 when her antibodies increased, although she had no symptoms.

Jacobs said the group encourages anyone with intestinal symptoms to seek medical help. Celiac can exhibit wide-ranging symptoms, however, including weight loss, malnutrition, anemia, osteoporosis, infertility, depression and constipation, according to the University of Maryland Center for Celiac Research.

In the Wheeler household, Linda estimates that 75 percent of the family dinners are glutenfree. Gluten-free products, often bought at health food stores, are pricey. A half-pound of glutenfree pasta costs about $6, the same price as six pounds of traditional pasta.

Fresh fruits, vegetables, meats and many other non-processed foods are gluten-free and fill the family’s kitchen as well.

“People assume we’re health nuts or don’t want them to have sugar,” Chris Wheeler said.

Chelsea loves food so much now after all those years without it that Chris Wheeler said he sometimes worries about her preoccupation: She wakes up knowing what she wants for breakfast, lunch and dinner. One of her favorite activities is grocery shopping. Since she is supposed to eat several small meals a day, they inevitably have to intervene with her eating.

“You never want to say, ‘No,’ if someone’s hungry,” Chris Wheeler said.

Cheslea is in half-day kindergarten, but has already missed a lot of school because of her medical problems, including the urge to “crash” after eating, Chris Wheeler said.

It was a milestone birthday when Chelsea turned 4 because she had her first birthday cake, gluten-free of course. More recently, the family found a restaurant in Waterbury that makes gluten-free pizza. It was a big day, Chris Wheeler said, when he could take Chelsea to get pizza, something most kids take for granted.

“It’s so worth going to Waterbury because you could see the excitement on her face,” he said.

Date: Mar 6, 2009

To see more of New Haven Register, or to subscribe to the newspaper, go to http://www.nhregister.com.

Copyright © 2009, New Haven Register, Conn.

Chelsea Wheeler, 6, had her first birthday cake at age 4 and her first take-out pizza only recently. The poignancy of those events isn't lost on her parents, Chris and Linda Wheeler.

Chelsea suffers from celiac disease, but it took so long to get to that diagnosis -- including 20 unnecessary surgeries -- that the Wheelers have made it a mission to raise research money and awareness about celiac, a genetic digestive disorder triggered by gluten, a protein found in wheat, barley and rye.

There is no cure or medication for celiac, but a gluten-free diet allows sufferers to lead normal lives. Chelsea's younger sister, Julia, also has the disease.

Unfortunately, Chelsea went through three years of sickness and life-altering surgeries before she was diagnosed. Since the disease has varied symptoms, from learning disabilities to wrenching intestinal pain, it is often misdiagnosed, so raising awareness even among doctors is a crucial part of the fight.

Chris Wheeler said that one in 133 Americans has celiac, but 95 percent are misdiagnosed.

"Chelsea is a worse case," Chris Wheeler said. "We just want to raise awareness so no one has to go through what she's gone through."

The Wheelers have organized a golf tournament and luncheon fundraiser, "Chip in for Celiac," which will take place May 15 at Whitney Farms Golf Course in Monroe. The luncheon will be open to those who don't golf. To sponsor, donate or reserve a spot or for more information, call Wheeler at (203) 463-9422.

After the diagnosis, the Wheelers became involved in the Greater New Haven Celiac Group, Chapter 75 of the Celiac Sprue Association. They heard other people's stories and shared information, including about gluten-free foods. Now, many people affected by the condition call Linda Wheeler for information or support.

The golf fund-raiser is sponsored by the University of Maryland. The proceeds will go to the university's Center for Celiac Research, with a portion to be directed to the New Haven group, which is helping with vendors and donations.

Despite having an army of medical specialists trying to find out why Chelsea could not gain weight and was throwing up full feedings as a baby, no one diagnosed Chelsea until Linda Wheeler, a very thin woman who had gone through many bouts of anemia, was found to have celiac.

Celiac hinders absorption of nutrients, often making its victims thin. Since the disease is genetic, Chelsea was tested and found to be positive; her three older siblings, ages 7 to 11, carry the gene and need to be tested every few years to watch for a rise in antibodies, but they don't exhibit symptoms yet and are not on gluten-free diets. The youngest, Julia, 2, was put on a glutenfree diet when she was unable to keep food down as a baby.

Although Chelsea has significant health problems stemming from her surgeries, she looks the picture of health these days. She has big, dark blue eyes, an engaging manner and a healthy weight.

But that wasn't always the case.

The Wheelers' ordeal began when Chelsea was about 2 weeks old and Linda, as instructed by doctors, was thickening her formula with barley. Chelsea, who had been born prematurely, was throwing up full feedings and was not gaining weight.

Suspecting it could be the barley, Linda took it out of Chelsea's formula about two weeks before she would be tested for celiac disease, among other ailments. The test came back negative because the barley had been out of her diet.

Linda Wheeler began giving her the barley in the bottle again. Chelsea lost so much weight she was admitted to the hospital at 8 months for a "nutrition rescue," meaning she was fed through an intravenous tube. She continued to throw up and at 11 months old was back in the hospital for another rescue because she had lost so much weight. She was 12.5 pounds at age 1.

Doctors tested for every liver, pancreatic and stomach disease they could think of, but turned up nothing, her parents said. She was seen at Yale-New Haven Hospital, Children's Medical Center in Hartford and Mount Sinai Hospital in New York.

It was at 13 months old that doctors performed major surgery to cut her stomach away from her spleen so she couldn't throw up. That surgery brought numerous complications and has left her, among other ailments, with a condition called "dumping" that causes her blood sugar to often spike then drop after eating, leaving her in need of a nap. She also has seizures and takes many daily medications. Because she can't throw up, when Chelsea gets a stomach bug, she just heaves with no relief, Chris Wheeler said.

In the years after the surgery, she still wasn't gaining weight. She was dependent on a feeding tube that entailed carrying equipment everywhere the family went.

Then, at about age 3 1/2, when the celiac disease diagnosis came for mom, Chelsea was finally properly diagnosed. A gluten-free diet was the simple remedy. Chelsea had been through 30 surgeries, 10 of them connected to trying to diagnose her problem.

"We look at the world in a different way; things that used to seem important aren't important anymore," Linda Wheeler said.

Bill Jacobs, president of the New Haven group, called Chelsea's story a sad one and said any money that goes toward the group from the golf tournament will be well spent on its many activities, including workshops, bringing in expert speakers on celiac and other supports, including updates on gluten-free food products and restaurant menus and a newsletter.

For more information on the group call Jacobs at 272-9646.

Jacobs was diagnosed 28 years ago and his daughter, now 17, was put on a gluten-free diet at age 13 when her antibodies increased, although she had no symptoms.

Jacobs said the group encourages anyone with intestinal symptoms to seek medical help. Celiac can exhibit wide-ranging symptoms, however, including weight loss, malnutrition, anemia, osteoporosis, infertility, depression and constipation, according to the University of Maryland Center for Celiac Research.

In the Wheeler household, Linda estimates that 75 percent of the family dinners are glutenfree. Gluten-free products, often bought at health food stores, are pricey. A half-pound of glutenfree pasta costs about $6, the same price as six pounds of traditional pasta.

Fresh fruits, vegetables, meats and many other non-processed foods are gluten-free and fill the family's kitchen as well.

"People assume we're health nuts or don't want them to have sugar," Chris Wheeler said.

Chelsea loves food so much now after all those years without it that Chris Wheeler said he sometimes worries about her preoccupation: She wakes up knowing what she wants for breakfast, lunch and dinner. One of her favorite activities is grocery shopping. Since she is supposed to eat several small meals a day, they inevitably have to intervene with her eating.

"You never want to say, 'No,' if someone's hungry," Chris Wheeler said.

Cheslea is in half-day kindergarten, but has already missed a lot of school because of her medical problems, including the urge to "crash" after eating, Chris Wheeler said.

It was a milestone birthday when Chelsea turned 4 because she had her first birthday cake, gluten-free of course. More recently, the family found a restaurant in Waterbury that makes gluten-free pizza. It was a big day, Chris Wheeler said, when he could take Chelsea to get pizza, something most kids take for granted.

"It's so worth going to Waterbury because you could see the excitement on her face," he said.

Date: Mar 6, 2009



To see more of New Haven Register, or to subscribe to the newspaper, go to http://www.nhregister.com.



Copyright © 2009, New Haven Register, Conn.

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Find Enough Folate For Your Health

Posted Mar 10, 2009

Folate, a vitamin that helps make the genetic material in cells and considered essential for pregnant women, may also help heart patients, a U.S. expert said.

Janice Hermann, an Oklahoma State University Cooperative Extension nutrition specialist, said folate works with vitamin B12 to make red blood cells, assists in preventing neural tube defects such as spina bifida in infants and may help protect against heart disease.

“If you have a low intake of folate, you may have anemia, weakness and fatigue,” Hermann said in a statement. “Not consuming enough folate, before and early in pregnancy, may increase the risk of having an infant with neural tube defects.”

Good sources of folate include liver, legumes, green-leafy vegetables and citrus fruits and juices. Many breads, cereals and grain products also are fortified with folate, Hermann said.

Hermann said the daily recommendations for folate are:

— Men age 19 and older; 400 micrograms per day.

— Women age 19 and older; 400 micrograms per day.

— Women who are pregnant 600 micrograms per day.

— Women who are breastfeeding 500 micrograms per day.

Because excess folate can mask symptoms of vitamin B12 deficiency, a tolerable upper intake level of 1,000 micrograms per day has been established for folate from fortified foods or supplements.

URL: www.upi.com

Date: Mar 7, 2009

Folate, a vitamin that helps make the genetic material in cells and considered essential for pregnant women, may also help heart patients, a U.S. expert said.

Janice Hermann, an Oklahoma State University Cooperative Extension nutrition specialist, said folate works with vitamin B12 to make red blood cells, assists in preventing neural tube defects such as spina bifida in infants and may help protect against heart disease.

"If you have a low intake of folate, you may have anemia, weakness and fatigue," Hermann said in a statement. "Not consuming enough folate, before and early in pregnancy, may increase the risk of having an infant with neural tube defects."

Good sources of folate include liver, legumes, green-leafy vegetables and citrus fruits and juices. Many breads, cereals and grain products also are fortified with folate, Hermann said.

Hermann said the daily recommendations for folate are:

-- Men age 19 and older; 400 micrograms per day.

-- Women age 19 and older; 400 micrograms per day.

-- Women who are pregnant 600 micrograms per day.

-- Women who are breastfeeding 500 micrograms per day.

Because excess folate can mask symptoms of vitamin B12 deficiency, a tolerable upper intake level of 1,000 micrograms per day has been established for folate from fortified foods or supplements.

URL: www.upi.com

Date: Mar 7, 2009

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