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IN THIS ISSUE:
  • 7 ways to save your memory

    According to natural health guru Dr. Andrew Weil, here are the top 7 ways to help prevent or lessen memory loss as we age: Add zing to your brainpower with foods and supplements. Challenge yourself. Evidence suggests that lifelong stimulation is the key to building and maintaining brain cells. Supplement with vitamins A, C and [...]

  • CoQ10 may benefit fibromyalgia

    Coenzyme Q10 may help fibromyalgia patients counteract higher levels of free radicals and benefit the disease, according to Spanish researchers. Their study on 37 patients with fibromyalgia found higher levels of markers of oxidative stress among patients with fibromyalgia, as compared to healthy controls. Those with fibromyalgia also had 40% less coQ10 in blood mononuclear [...]

  • Antioxidant blend protects hearing

    Hearing loss affects about 10 million people in the US alone, from troops returning from war to students with music blasting through headphones. Now researchers at the University of Michigan Kresge Hearing Research Institute are hoping to address the growing problem with a cocktail of vitamins and the mineral magnesium. The nutrients were successful in [...]

  • Canker sores – What they mean and what to do

    Canker sores, also known as aphthous ulcers, appear as shallow, light-coloured mouth sores of different sizes and affect one in five North Americans. While no one is certain of any single cause, research does point to a few possibilities. Among them, a genetic predisposition might be the biggest cause, says Michael Martin, PhD, of the [...]

  • Chondroitin eases arthritis pain

    Long-term use of chondroitin sulfate reduces arthritis knee pain and slows joint narrowing, say French researchers. The Study on Osteoarthritis Progression Prevention (STOPP) involved 622 patients in Europe and the US, ages 45-80 years, with knee arthritis. Knee pain decreased significantly without side effects. On average, the patients reported moderate levels of pain when the [...]

  • Great skin on a budget!

    "The cost-effective alternative to pricey moisturizing creams for dry skin is one tablespoon of flax seed oil [per day] per 100 pounds of body weight. Not only will your skin benefit, but every cell in your body will be healthier." Herb Joiner-Bey, ND, author of The Healing Power of Flax Source: Vitamin Retailer, Jan 2009

  • Eat those eggs!

    Think eating eggs raises your cholesterol? Not so, according to researchers from Thailand’s Samutsakhon General Hospital. In a study with 56 healthy adults with an average age of 35 years, eating one additional egg per day over 12 weeks actually boosted HDL (good) cholesterol levels and had no impact on LDL (bad) cholesterol levels. The [...]

  • Hope for bi-polar disorder?

    Researchers from Australia say that treatment with N-acetylcysteine (NAC) can help reduce depressive symptoms in those with bipolar disorder. NAC is a precursor of glutathione, and glutathione depletion is known to exist in both depression and bipolar disorder. Their 6-month study on 75 subjects with bipolar disorder saw a significant decrease in the Montgomery Asberg [...]

  • Low D common in kids

    In a cross-sectional study of 380 healthy infants and toddlers by researchers at the Children’s Hospital Boston, 12% were found to be vitamin D deficient and 40% were found to have less than optimal vitamin D levels. Predictors of vitamin D deficiency included: breastfeeding without supplementation among infants, and lower milk intake among toddlers. The [...]

  • Nutrition Wise Q&A

    Nutrition questions answered by Karen Collins, MS, RD, CDN of the American Institute for Cancer Research Many spices, such as turmeric, contain beneficial compounds. Q: Is the anti-cancer compound curcumin found in both turmeric and curry powder? A: Technically, yes, but turmeric is a more concentrated source. Curcumin is the yellow pigment found in the [...]

  • Relieve menstrual pain

    Japanese researchers performed a double-blind, placebo-controlled study involving 116 women between 16 and 48 years, with either dysmenorrhea or some menstrual pain. They found that supplementation with 60 mg per day of Pycnogenol (French maritime pine bark extract) for two menstrual cycles significantly reduced menstrual pain and the amount of and need for analgesic medication. [...]

  • Resveratrol blocks cancer, fat cells

    Early lab research has shown that resveratrol suppresses the abnormal cell formation that leads to most types of breast cancer, suggesting a potential role in breast cancer prevention. Resveratrol is a natural substance found in red wine and red grapes. Red grapes are one source of anti-cancer resveratrol. "Resveratrol has the ability to prevent the [...]

  • Tea extract, cancer drug don’t mix

    US researchers warn that people using a cancer drug used to treat multiple myeloma and mantle cell lymphoma should not drink green tea or take green tea supplements. Their recent animal study showed that a compound in green tea, EGCG, destroys any anticancer activity of the drug Velcade in tumor-bearing mice. The researchers found the [...]

7 ways to save your memory

According to natural health guru Dr. Andrew Weil, here are the top 7 ways to help prevent or lessen memory loss as we age:

  • Add zing to your brainpower with foods and supplements.
  • Challenge yourself. Evidence suggests that lifelong stimulation is the key to building and maintaining brain cells.
  • Supplement with vitamins A, C and E. A study at Johns Hopkins University suggested that when taken together, the vitamins might slow the progression of Alzheimer’s.
  • Use a daily multivitamins that provides adequate levels of folic acid and other B-vitamins. They help the body reduce levels of homocysteine, an amino acid formed by the breakdown of animal protein. At elevated levels in the bloodstream, it has been linked with increased risks of Alzheimer’s.
  • Use healing spices in your cooking: Turmeric, ginger and red pepper can add zing to meals and are all natural anti-inflammatories.
  • Eat a diet rich in omega 3 fatty acids, including wild Alaskan salmon, sardines, freshly ground flaxseed and walnuts.
  • Incorporate plenty of fresh organic fruits and vegetables in your meals.
  • Reduce your intake of polyunsaturated vegetable oils (such as sunflower, corn and safflower oils), replacing them instead with a high-quality extra-virgin olive oil.

Source: Lancaster New Era, Jan 21, 2009

According to natural health guru Dr. Andrew Weil, here are the top 7 ways to help prevent or lessen memory loss as we age:
  • Add zing to your brainpower with foods and supplements.
  • Challenge yourself. Evidence suggests that lifelong stimulation is the key to building and maintaining brain cells.
  • Supplement with vitamins A, C and E. A study at Johns Hopkins University suggested that when taken together, the vitamins might slow the progression of Alzheimer's.
  • Use a daily multivitamins that provides adequate levels of folic acid and other B-vitamins. They help the body reduce levels of homocysteine, an amino acid formed by the breakdown of animal protein. At elevated levels in the bloodstream, it has been linked with increased risks of Alzheimer's.
  • Use healing spices in your cooking: Turmeric, ginger and red pepper can add zing to meals and are all natural anti-inflammatories.
  • Eat a diet rich in omega 3 fatty acids, including wild Alaskan salmon, sardines, freshly ground flaxseed and walnuts.
  • Incorporate plenty of fresh organic fruits and vegetables in your meals.
  • Reduce your intake of polyunsaturated vegetable oils (such as sunflower, corn and safflower oils), replacing them instead with a high-quality extra-virgin olive oil.
Source: Lancaster New Era, Jan 21, 2009

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CoQ10 may benefit fibromyalgia

Coenzyme Q10 may help fibromyalgia patients counteract higher levels of free radicals and benefit the disease, according to Spanish researchers. Their study on 37 patients with fibromyalgia found higher levels of markers of oxidative stress among patients with fibromyalgia, as compared to healthy controls. Those with fibromyalgia also had 40% less coQ10 in blood mononuclear cells, as compared to healthy controls. "The distribution of CoQ10 in blood components was altered in [fibromyalgia] patients," said the authors. "Also, our results confirm the oxidative stress background of this disease probably due to a defect on the distribution and metabolism of coQ10 in cells and tissues." They say the results would indicate a benefit from supplementation in fibromyalgia patients.

Source: Clinical Biochemistry, Accepted Manuscript, 2009

Coenzyme Q10 may help fibromyalgia patients counteract higher levels of free radicals and benefit the disease, according to Spanish researchers. Their study on 37 patients with fibromyalgia found higher levels of markers of oxidative stress among patients with fibromyalgia, as compared to healthy controls. Those with fibromyalgia also had 40% less coQ10 in blood mononuclear cells, as compared to healthy controls. "The distribution of CoQ10 in blood components was altered in [fibromyalgia] patients," said the authors. "Also, our results confirm the oxidative stress background of this disease probably due to a defect on the distribution and metabolism of coQ10 in cells and tissues." They say the results would indicate a benefit from supplementation in fibromyalgia patients.

Source: Clinical Biochemistry, Accepted Manuscript, 2009

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Antioxidant blend protects hearing

Hearing loss affects about 10 million people in the US alone, from troops returning from war to students with music blasting through headphones. Now researchers at the University of Michigan Kresge Hearing Research Institute are hoping to address the growing problem with a cocktail of vitamins and the mineral magnesium. The nutrients were successful in laboratory tests, and now researchers are testing whether humans will benefit as well.

MP3 players are linked to a rise in hearing problems.

"When we can’t prevent noise-induced hearing loss through use of hearing protection, then we really need to come up with some way of protecting people who are still going to have noise exposure," says says Glenn E. Green, MD. "My hope is that this [combination] will give people a richer, fuller life."

In their animal study, the combination of vitamins A, C and E, plus magnesium blocked about 80% of the noise-induced hearing impairment. Now the formula is being tested in a set of four multinational human clinical trials: military trials in Sweden and Spain, an industrial trial in Spain, and a trial involving students at the University of Florida who listen to music at high volumes on their iPods and other PDAs.

"If we can even see 50% of the effectiveness in humans that we saw in our animal trials, we will have an effective treatment that will very significantly reduce noise-induced hearing impairment in humans.

Source: University of Michagan Health System, Nov 10, 2008

Hearing loss affects about 10 million people in the US alone, from troops returning from war to students with music blasting through headphones. Now researchers at the University of Michigan Kresge Hearing Research Institute are hoping to address the growing problem with a cocktail of vitamins and the mineral magnesium. The nutrients were successful in laboratory tests, and now researchers are testing whether humans will benefit as well.

MP3 players are linked to a rise in hearing problems.

"When we can't prevent noise-induced hearing loss through use of hearing protection, then we really need to come up with some way of protecting people who are still going to have noise exposure," says says Glenn E. Green, MD. "My hope is that this [combination] will give people a richer, fuller life."

In their animal study, the combination of vitamins A, C and E, plus magnesium blocked about 80% of the noise-induced hearing impairment. Now the formula is being tested in a set of four multinational human clinical trials: military trials in Sweden and Spain, an industrial trial in Spain, and a trial involving students at the University of Florida who listen to music at high volumes on their iPods and other PDAs.

"If we can even see 50% of the effectiveness in humans that we saw in our animal trials, we will have an effective treatment that will very significantly reduce noise-induced hearing impairment in humans.

Source: University of Michagan Health System, Nov 10, 2008

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Canker sores – What they mean and what to do

Canker sores, also known as aphthous ulcers, appear as shallow, light-coloured mouth sores of different sizes and affect one in five North Americans. While no one is certain of any single cause, research does point to a few possibilities. Among them, a genetic predisposition might be the biggest cause, says Michael Martin, PhD, of the Department of Oral Medicine at the University of Washington.

Certain foods, such as citrus fruits, can make painful canker sores worse.

"When both parents have a history of canker sores, the likelihood of their children developing them can be as high as 90%," he says. Other research points to food allergies and hormonal changes, such as chronic stress, anxiety and the menstrual cycle.

Recent research provides a few other clues on what may be behind canker sores and what to do about them.

B12 is key

A team of physicians at Ben-Gurion University say that a nightly dose of vitamin B12 is a simple, effective and low-risk therapy to prevent canker sores. They tested 58 randomly selected patients with recurrent canker sores who received either 1,000 mcg of B12 by mouth at bedtime or a placebo, and were tested monthly for six months. Almost three quarters of the patients taking B12 and only a third of the control group achieved remission at the end of the study. The treated patients expressed greater comfort, reported less pain, fewer ulcers, and shorter outbreaks during the six months while among the control group the average pain level decreased during the first half of the period but increased during the second half.

Herbal help

Other researchers examined the effects of licorice extract applied via an adhesive patch for treatment of canker sores versus no treatment. After seven days of treatment, ulcer size in the group who took the licorice was significantly lower, while ulcer size in the no-treatment group had increased 13%.

Licorice, typically in the form of DGL (deglycyrrhizinated licorice) is also widely used as a treatment for gastric ulcers. DGL lozenges are available in health food stores and may be an alternative to adhesive patches. Dr Michael Martin adds that "in addition to speeding healing of the canker sores, the licorice extract helped to reduce pain after just three days of treatment."

Nutrition clues

An earlier study points to other nutrient deficiencies that may contribute to canker sores. Japanese researchers compared food intake among patients with recurrent canker sores and control patients. They found a significantly positive correlation with lower intake of calcium, iron, vitamin B1 and vitamin C among canker sore sufferers. They concluded that "not only iron and vitamin B1 might be deficient in these patients but also calcium and vitamin C."

Sources: General Dentistry, Mar/Apr 2008; Ben-Gurion University of the Negev, Feb 10, 2009; Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001 Jan;91(1):45-9

Canker sores, also known as aphthous ulcers, appear as shallow, light-coloured mouth sores of different sizes and affect one in five North Americans. While no one is certain of any single cause, research does point to a few possibilities. Among them, a genetic predisposition might be the biggest cause, says Michael Martin, PhD, of the Department of Oral Medicine at the University of Washington.

Certain foods, such as citrus fruits, can make painful canker sores worse.

"When both parents have a history of canker sores, the likelihood of their children developing them can be as high as 90%," he says. Other research points to food allergies and hormonal changes, such as chronic stress, anxiety and the menstrual cycle.

Recent research provides a few other clues on what may be behind canker sores and what to do about them.

B12 is key

A team of physicians at Ben-Gurion University say that a nightly dose of vitamin B12 is a simple, effective and low-risk therapy to prevent canker sores. They tested 58 randomly selected patients with recurrent canker sores who received either 1,000 mcg of B12 by mouth at bedtime or a placebo, and were tested monthly for six months. Almost three quarters of the patients taking B12 and only a third of the control group achieved remission at the end of the study. The treated patients expressed greater comfort, reported less pain, fewer ulcers, and shorter outbreaks during the six months while among the control group the average pain level decreased during the first half of the period but increased during the second half.

Herbal help

Other researchers examined the effects of licorice extract applied via an adhesive patch for treatment of canker sores versus no treatment. After seven days of treatment, ulcer size in the group who took the licorice was significantly lower, while ulcer size in the no-treatment group had increased 13%.

Licorice, typically in the form of DGL (deglycyrrhizinated licorice) is also widely used as a treatment for gastric ulcers. DGL lozenges are available in health food stores and may be an alternative to adhesive patches. Dr Michael Martin adds that "in addition to speeding healing of the canker sores, the licorice extract helped to reduce pain after just three days of treatment."

Nutrition clues

An earlier study points to other nutrient deficiencies that may contribute to canker sores. Japanese researchers compared food intake among patients with recurrent canker sores and control patients. They found a significantly positive correlation with lower intake of calcium, iron, vitamin B1 and vitamin C among canker sore sufferers. They concluded that "not only iron and vitamin B1 might be deficient in these patients but also calcium and vitamin C."

Sources: General Dentistry, Mar/Apr 2008; Ben-Gurion University of the Negev, Feb 10, 2009; Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001 Jan;91(1):45-9

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Chondroitin eases arthritis pain

Long-term use of chondroitin sulfate reduces arthritis knee pain and slows joint narrowing, say French researchers. The Study on Osteoarthritis Progression Prevention (STOPP) involved 622 patients in Europe and the US, ages 45-80 years, with knee arthritis.

Knee pain decreased significantly without side effects.

On average, the patients reported moderate levels of pain when the study began. Patients were then randomly assigned to two years of daily treatment with either chondroitin or an inactive placebo. X-rays of the affected knee were taken to assess the impact of treatment.

The researchers found that pain decreased with time in the chondroitin group and also reduced the likelihood of joint narrowing (indicating a loss of cartilage)by 33%.

In all, more than 90% of the subjects reported good or very good tolerability with chondroitin sulfate, and side effects were no more likely than with placebo. Chondroitin is often found in combination with glucosamine, another well researched and effective arthritis and joint pain remedy.

Source: Arthritis & Rheumatism, Feb 2009

Long-term use of chondroitin sulfate reduces arthritis knee pain and slows joint narrowing, say French researchers. The Study on Osteoarthritis Progression Prevention (STOPP) involved 622 patients in Europe and the US, ages 45-80 years, with knee arthritis.

Knee pain decreased significantly without side effects.

On average, the patients reported moderate levels of pain when the study began. Patients were then randomly assigned to two years of daily treatment with either chondroitin or an inactive placebo. X-rays of the affected knee were taken to assess the impact of treatment.

The researchers found that pain decreased with time in the chondroitin group and also reduced the likelihood of joint narrowing (indicating a loss of cartilage)by 33%.

In all, more than 90% of the subjects reported good or very good tolerability with chondroitin sulfate, and side effects were no more likely than with placebo. Chondroitin is often found in combination with glucosamine, another well researched and effective arthritis and joint pain remedy.

Source: Arthritis & Rheumatism, Feb 2009

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Great skin on a budget!

"The cost-effective alternative to pricey moisturizing creams for dry skin is one tablespoon of flax seed oil [per day] per 100 pounds of body weight. Not only will your skin benefit, but every cell in your body will be healthier." Herb Joiner-Bey, ND, author of The Healing Power of Flax

Source: Vitamin Retailer, Jan 2009

"The cost-effective alternative to pricey moisturizing creams for dry skin is one tablespoon of flax seed oil [per day] per 100 pounds of body weight. Not only will your skin benefit, but every cell in your body will be healthier." Herb Joiner-Bey, ND, author of The Healing Power of Flax

Source: Vitamin Retailer, Jan 2009

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Eat those eggs!

Think eating eggs raises your cholesterol? Not so, according to researchers from Thailand’s Samutsakhon General Hospital. In a study with 56 healthy adults with an average age of 35 years, eating one additional egg per day over 12 weeks actually boosted HDL (good) cholesterol levels and had no impact on LDL (bad) cholesterol levels. The authors say, "In the majority of healthy adults, an addition of one egg per day to a normal fat diet could raise HDL-c levels and decrease the ratio of [total cholesterol] to HDL-c. Therefore, egg consumption might benefit blood cholesterol."

Source: J Med Assoc Thai, 2008; 91(3): 400-7

Think eating eggs raises your cholesterol? Not so, according to researchers from Thailand's Samutsakhon General Hospital. In a study with 56 healthy adults with an average age of 35 years, eating one additional egg per day over 12 weeks actually boosted HDL (good) cholesterol levels and had no impact on LDL (bad) cholesterol levels. The authors say, "In the majority of healthy adults, an addition of one egg per day to a normal fat diet could raise HDL-c levels and decrease the ratio of [total cholesterol] to HDL-c. Therefore, egg consumption might benefit blood cholesterol."

Source: J Med Assoc Thai, 2008; 91(3): 400-7

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Hope for bi-polar disorder?

Researchers from Australia say that treatment with N-acetylcysteine (NAC) can help reduce depressive symptoms in those with bipolar disorder. NAC is a precursor of glutathione, and glutathione depletion is known to exist in both depression and bipolar disorder. Their 6-month study on 75 subjects with bipolar disorder saw a significant decrease in the Montgomery Asberg Depression Rating Scale (MADRS) five months after starting supplementation with NAC. Improvements in the Global Assessment of Functioning Scale and Social and Occupational Functioning Assessment Scale were found 2 months after beginning NAC supplementation. They say NAC may be an effective adjunctive treatment in patients with bipolar disorder.

Source: Biol Psychiatry, 2008 June 4; [Epub ahead of print]

Researchers from Australia say that treatment with N-acetylcysteine (NAC) can help reduce depressive symptoms in those with bipolar disorder. NAC is a precursor of glutathione, and glutathione depletion is known to exist in both depression and bipolar disorder. Their 6-month study on 75 subjects with bipolar disorder saw a significant decrease in the Montgomery Asberg Depression Rating Scale (MADRS) five months after starting supplementation with NAC. Improvements in the Global Assessment of Functioning Scale and Social and Occupational Functioning Assessment Scale were found 2 months after beginning NAC supplementation. They say NAC may be an effective adjunctive treatment in patients with bipolar disorder.

Source: Biol Psychiatry, 2008 June 4; [Epub ahead of print]

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Low D common in kids

In a cross-sectional study of 380 healthy infants and toddlers by researchers at the Children’s Hospital Boston, 12% were found to be vitamin D deficient and 40% were found to have less than optimal vitamin D levels. Predictors of vitamin D deficiency included: breastfeeding without supplementation among infants, and lower milk intake among toddlers. The authors conclude, "Suboptimal vitamin D status is common among otherwise healthy young children."

Source: Arch Pediatr Adolesc Med, 2008;162(6): 505-12

In a cross-sectional study of 380 healthy infants and toddlers by researchers at the Children's Hospital Boston, 12% were found to be vitamin D deficient and 40% were found to have less than optimal vitamin D levels. Predictors of vitamin D deficiency included: breastfeeding without supplementation among infants, and lower milk intake among toddlers. The authors conclude, "Suboptimal vitamin D status is common among otherwise healthy young children."

Source: Arch Pediatr Adolesc Med, 2008;162(6): 505-12

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Nutrition Wise Q&A

Nutrition questions answered by Karen Collins, MS, RD, CDN of the American Institute for Cancer Research

Many spices, such as turmeric, contain beneficial compounds.

Q: Is the anti-cancer compound curcumin found in both turmeric and curry powder?

A: Technically, yes, but turmeric is a more concentrated source. Curcumin is the yellow pigment found in the ground spice called turmeric. Although curcumin content will vary from one batch of the spice to another, the curcumin content of curry powder is much more variable, since curry powder is not just one spice, but a mixture of turmeric, cumin, fenugreek and other spices. Emerging research suggests that curcumin may affect the activity of genes and proteins that control cell growth and cancer development, including the ability to stimulate cancer cell self-destruction. We still need to learn more about how well the body absorbs curcumin from food and what amounts provide optimal effects. Meanwhile, since turmeric provides flavour and colour, some experts suggest adding a little extra turmeric when cooking, even if you start with a commercial curry powder as your base.

Source: American Institute for Cancer Research (www.aicr.org)

Nutrition questions answered by Karen Collins, MS, RD, CDN of the American Institute for Cancer Research

Many spices, such as turmeric, contain beneficial compounds.

Q: Is the anti-cancer compound curcumin found in both turmeric and curry powder?

A:
Technically, yes, but turmeric is a more concentrated source. Curcumin is the yellow pigment found in the ground spice called turmeric. Although curcumin content will vary from one batch of the spice to another, the curcumin content of curry powder is much more variable, since curry powder is not just one spice, but a mixture of turmeric, cumin, fenugreek and other spices. Emerging research suggests that curcumin may affect the activity of genes and proteins that control cell growth and cancer development, including the ability to stimulate cancer cell self-destruction. We still need to learn more about how well the body absorbs curcumin from food and what amounts provide optimal effects. Meanwhile, since turmeric provides flavour and colour, some experts suggest adding a little extra turmeric when cooking, even if you start with a commercial curry powder as your base.

Source: American Institute for Cancer Research (www.aicr.org)

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Relieve menstrual pain

Japanese researchers performed a double-blind, placebo-controlled study involving 116 women between 16 and 48 years, with either dysmenorrhea or some menstrual pain. They found that supplementation with 60 mg per day of Pycnogenol (French maritime pine bark extract) for two menstrual cycles significantly reduced menstrual pain and the amount of and need for analgesic medication. They also noted a decrease in the number of days that women with dysmenorrhea experienced menstrual pain, as well as the number of days that analgesic medication was required. Benefits remained even after supplementation was stopped.

Source: J Reprod Med, 2008; 53(5): 338-46

Japanese researchers performed a double-blind, placebo-controlled study involving 116 women between 16 and 48 years, with either dysmenorrhea or some menstrual pain. They found that supplementation with 60 mg per day of Pycnogenol (French maritime pine bark extract) for two menstrual cycles significantly reduced menstrual pain and the amount of and need for analgesic medication. They also noted a decrease in the number of days that women with dysmenorrhea experienced menstrual pain, as well as the number of days that analgesic medication was required. Benefits remained even after supplementation was stopped.

Source: J Reprod Med, 2008; 53(5): 338-46

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Resveratrol blocks cancer, fat cells

Early lab research has shown that resveratrol suppresses the abnormal cell formation that leads to most types of breast cancer, suggesting a potential role in breast cancer prevention. Resveratrol is a natural substance found in red wine and red grapes.

Red grapes are one source of anti-cancer resveratrol.

"Resveratrol has the ability to prevent the first step that occurs when estrogen starts the process that leads to cancer by blocking the formation of the estrogen DNA adducts. We believe that this could stop the whole progression that leads to breast cancer down the road," said Eleanor G. Rogan, Ph.D., a professor at the University of Nebraska Medical Center.

The formation of breast cancer is a multi-step process which differs depending on type of disease, a patient’s genetic makeup and other factors. However, scientists know that many breast cancers are fueled by increased estrogen, which collects and reacts with DNA molecules to form adducts. Rogan and colleagues found that resveratrol was able to suppress the formation of these DNA adducts.

"This is dramatic because it was able to be done with fairly low concentrations of resveratrol to stop the formation of these DNA adducts in the cells we studied," said Rogan. The current study was conducted in laboratory cultures, and will need to be confirmed in larger human trials, Rogan said.

In an earlier study, German researchers found that resveratrol inhibited pre-fat cells from increasing and prevented them from converting into mature fat cells. Also, resveratrol hindered fat storage. Most interesting, according to the lead author, was that resveratrol reduced production of substances that may be linked to the development of obesity-related disorders, such as diabetes and clogged coronary arteries.

Source: American Association for Cancer Research, Jul 7, 2008; Endocrine Society, Jun 11, 2008

Early lab research has shown that resveratrol suppresses the abnormal cell formation that leads to most types of breast cancer, suggesting a potential role in breast cancer prevention. Resveratrol is a natural substance found in red wine and red grapes.

Red grapes are one source of anti-cancer resveratrol.

"Resveratrol has the ability to prevent the first step that occurs when estrogen starts the process that leads to cancer by blocking the formation of the estrogen DNA adducts. We believe that this could stop the whole progression that leads to breast cancer down the road," said Eleanor G. Rogan, Ph.D., a professor at the University of Nebraska Medical Center.

The formation of breast cancer is a multi-step process which differs depending on type of disease, a patient's genetic makeup and other factors. However, scientists know that many breast cancers are fueled by increased estrogen, which collects and reacts with DNA molecules to form adducts. Rogan and colleagues found that resveratrol was able to suppress the formation of these DNA adducts.

"This is dramatic because it was able to be done with fairly low concentrations of resveratrol to stop the formation of these DNA adducts in the cells we studied," said Rogan. The current study was conducted in laboratory cultures, and will need to be confirmed in larger human trials, Rogan said.

In an earlier study, German researchers found that resveratrol inhibited pre-fat cells from increasing and prevented them from converting into mature fat cells. Also, resveratrol hindered fat storage. Most interesting, according to the lead author, was that resveratrol reduced production of substances that may be linked to the development of obesity-related disorders, such as diabetes and clogged coronary arteries.

Source: American Association for Cancer Research, Jul 7, 2008; Endocrine Society, Jun 11, 2008

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Tea extract, cancer drug don’t mix

US researchers warn that people using a cancer drug used to treat multiple myeloma and mantle cell lymphoma should not drink green tea or take green tea supplements. Their recent animal study showed that a compound in green tea, EGCG, destroys any anticancer activity of the drug Velcade in tumor-bearing mice. The researchers found the EGCG molecule and the Velcade molecule were able to form chemical bonds, meaning that the Velcade molecule could no longer bind to its intended target inside the tumor cells. The researchers are also studying another well-established chemotherapeutic drug, where in that case the inclusion of EGCG appears to yield an ‘encouragingly beneficial’ outcome.

Source: University of Southern California, Feb 3, 2009

US researchers warn that people using a cancer drug used to treat multiple myeloma and mantle cell lymphoma should not drink green tea or take green tea supplements. Their recent animal study showed that a compound in green tea, EGCG, destroys any anticancer activity of the drug Velcade in tumor-bearing mice. The researchers found the EGCG molecule and the Velcade molecule were able to form chemical bonds, meaning that the Velcade molecule could no longer bind to its intended target inside the tumor cells. The researchers are also studying another well-established chemotherapeutic drug, where in that case the inclusion of EGCG appears to yield an 'encouragingly beneficial' outcome.

Source: University of Southern California, Feb 3, 2009

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